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Utilisant des approches divergentes, on a réalisé des synthèses de nouveaux mésogènes en forme étoilée à base d'acide trimésique et des portions centrales portant des chaînes latérales symétriques se terminant par des groupes alcoxy. Les portions centrales et les chaînes latérales sont liée ... mehr
HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fate of HIF1A mRNA. In the present study, we ... mehr
Asthma is a debilitating chronic inflammatory disease of the airways that results in shortness of breath, wheezing and coughing, often triggered by inhalation of common allergens. The prevalence and severity of asthma has increased dramatically over the last several decades to the point wh ... mehr
Genetic variation plays a major role in drug response variability. CsA (cyclosporin A), a widely used immunosuppressive agent, is a specific antagonist for FPR1 (formyl peptide receptor 1), which is an important G-protein-coupled chemoattractant receptor in the innate immune system. In ord ... mehr
PSCs (pluripotent stem cells) possess two key properties that have made them the focus of global research efforts in regenerative medicine: they have unlimited expansion potential under conditions which favour their preservation as PSCs and they have the ability to generate all somatic cel ... mehr
This paper presents a novel rhodamine diphosphate molecule that allows highly-sensitive detection of proteins by employing sequential enzyme-linked immunosorbent assay and capillary isoelectric focusing (ELISA-cIEF). Seven-fold improvement in the immunoassay sensitivity and a 1-2 order of m ... mehr
We have developed a three-dimensional (3D) liver-on-a-chip to investigate the interaction of hepatocytes and hepatic stellate cells (HSCs) in which primary 3D hepatocyte spheroids and HSCs are co-cultured without direct cell-cell contact. Here, we show that the 3D liver chip offers substant ... mehr
We describe a generic microfluidic interface design that allows connecting microfluidic chips to established industrial liquid handling stations (LHS). A moulding tool has been designed that allows fabrication of low-cost disposable polydimethylsiloxane (PDMS) chips with interfaces that pro ... mehr
A novel biosensor was developed based on tyrosinase immobilization with ordered mesoporous carbon-Au (OMC-Au), L-Lysine membrane and Au nanoparticles on glassy carbon electrode (GCE), and applied for simultaneous determination of dihydroxybenzene isomers using the differential pulse voltamm ... mehr
Aiming at the facile detection of lengthy DNA molecules, an easily-operated sandwich-type electrochemiluminescence (ECL) DNA biosensor was constructed on glassy carbon electrode (GCE) based on CdTe quantum dots coated hollow ZnO nanoparticles (CdTe/ZnO NPs)-S2O82- ECL system in this work. T ... mehr
Utilisant des approches divergentes, on a réalisé des synthèses de nouveaux mésogènes en forme étoilée à base d'acide trimésique et des portions centrales portant des chaînes latérales symétriques se terminant par des groupes alcoxy. Les portions centrales et les chaînes latérales sont liée ... mehr
HIF1A (hypoxia-inducible factor 1α) is the master regulator of the cellular response to hypoxia and is implicated in cancer progression. Whereas the regulation of HIF1A protein in response to oxygen is well characterized, less is known about the fate of HIF1A mRNA. In the present study, we ... mehr
Asthma is a debilitating chronic inflammatory disease of the airways that results in shortness of breath, wheezing and coughing, often triggered by inhalation of common allergens. The prevalence and severity of asthma has increased dramatically over the last several decades to the point wh ... mehr
Genetic variation plays a major role in drug response variability. CsA (cyclosporin A), a widely used immunosuppressive agent, is a specific antagonist for FPR1 (formyl peptide receptor 1), which is an important G-protein-coupled chemoattractant receptor in the innate immune system. In ord ... mehr
PSCs (pluripotent stem cells) possess two key properties that have made them the focus of global research efforts in regenerative medicine: they have unlimited expansion potential under conditions which favour their preservation as PSCs and they have the ability to generate all somatic cel ... mehr
Inside Lab Invest Laboratory Investigation 93, 376 (April 2013). doi:10.1038/labinvest.2013.49 mehr
Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes, and neutrophils, and the oxidative burst from human blood Laboratory Investigation advance online publication, March 25 2013. doi:10.1038/labinvest.2013.53 Authors: Balu K Chacko, Phili ... mehr
Inside Lab Invest Laboratory Investigation 93, 266 (March 2013). doi:10.1038/labinvest.2013.11 mehr
Hydroxylases as therapeutic targets in inflammatory bowel disease Laboratory Investigation advance online publication, February 18 2013. doi:10.1038/labinvest.2013.9 Authors: Eoin P Cummins, Glen A Doherty & Cormac T Taylor mehr
Sonic Hedgehog contributes to gastric mucosal restitution after injury Laboratory Investigation 93, 264 (February 2013). doi:10.1038/labinvest.2012.170 Authors: Chang Xiao, Rui Feng, Amy C Engevik, Jason R Martin, Julie A Tritschler, Michael Schumacher, Robert Koncar ... mehr
Abstract The present work reports the effect of bentonite clay on methane hydrate formation and dissociation in synthetic seawater of salinity 3.55 % of total dissolved salts. Extensive observations of pressure‐temperature equilibrium during formation and decomposition of methane hydrat ... mehr
Abstract An ultrasonic enhanced salt‐containing hydrodistillation (UESHD) method for separating essential oil from lavender (Lavandula angustifolia) flowers was investigated using response surface methodology (RSM). The experimental data obtained from a 27‐run experiment were fitted to ... mehr
Abstract The prediction of nominal strength is very important in the design and evaluation of materials especially polymer matrix composites. Various cohesive laws forms are successfully used in predicting the nominal strength of laminated composite structures. For composite structures, ... mehr
Abstract Nonlinear stress relaxation is far more difficult to model than creep. The present work shows that in the case of a polymer, focusing on the material's nonaffine local strains and stresses provides a sound basis for modeling stress relaxation in a physically realistic way. This ... mehr
ABSTRACT The incomplete regeneration of diesel particulate filter may cause a local build‐up of the soot on the partially regenerated areas during next filtration cycle. This may be one of reasons causing the melting of the ceramic filter during regeneration. In this paper, we investiga ... mehr
The batch equilibrium approach was used to examine the influence of multi-walled carbon nanotubes (MWNTs) on the sorption behaviors of polyaromatic hydrocarbons (PAHs) in soil. To the knowledge of the authors, this is the first study of PAH sorption to MWNTs in real natural soil systems. Th ... mehr
A new and easy fast-screening test (the Ad-DR bioassay) for dioxins in biological samples from highly dioxin-contaminated areas was developed. The aryl-hydrocarbon-receptor (AhR) reporter system was utilized to transport dioxin-responsive-element (DRE) via an adenovirus vector into a rat he ... mehr
In the Noorderkempen (NW Belgium), a large area (about 280 km²)is contaminated with cadmium (Cd) and zinc (Zn) due to a historical pollution by the Zn smelters. Direct aquatic emissions of metals have strongly reduced from historic ones, however surface water metal concentration largely exc ... mehr
An efficient and economic approach is proposed for the fast and direct recovery of silica materials from photonic waste powder. Unlike the conventional alkaline fusion method for the extraction of silica from waste materials, this method possesses advantages of a rapid and low-energy-consum ... mehr
A key advantage of using microalgae for biofuel production is the ability of some algal strains to thrive in waters unsuitable for conventional crop irrigation such as saline groundwater or seawater. Nonetheless, the availability of sustainable water supplies will provide significant challe ... mehr
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