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Aktuelle Fachpublikationen

Dissection of mechanical force in living cells by super-resolved traction force microscopy

Nature Protocols 12, 783 (2017). doi:10.1038/nprot.2017.009 Authors: Huw Colin-York, Christian Eggeling & Marco Fritzsche Cells continuously exert or respond to mechanical force. Measurement of these nanoscale forces is a major challenge in cell biology; yet such measurem ... mehr

Translation complex profile sequencing to study the in vivo dynamics of mRNA–ribosome interactions during translation initiation, elongation and termination

Nature Protocols 12, 697 (2017). doi:10.1038/nprot.2016.189 Authors: Nikolay E Shirokikh, Stuart K Archer, Traude H Beilharz, David Powell & Thomas Preiss Messenger RNA (mRNA) translation is a tightly controlled process that is integral to gene expression. It features int ... mehr

An efficient noble-metal-free supported copper catalyst for selective nitrocyclohexane hydrogenation to cyclohexanone oxime

It was shown for the first time that cyclohexanone oxime (CHO) can be selectively produced by heterogeneous copper-catalyzed hydrogenative transformation of nitrocyclohexane (NC). The combination of Cu0 and Cu+ and their cooperative interaction with weakly acidic SiO2 supports elicited a si ... mehr

Interpolated energy densities, correlation indicators and lower bounds from approximations to the strong coupling limit of DFT

We investigate the construction of approximated exchange–correlation functionals by interpolating locally along the adiabatic connection between the weak- and the strong-coupling regimes, focussing on the effect of using approximate functionals for the strong-coupling energy densities. The ... mehr

Aromatic metamorphosis: conversion of an aromatic skeleton into a different ring system

Aromatic skeletons are generally regarded as being uncleavable because of their aromatic stabilization energy. Compared to exocyclic functionalizations of aromatic compounds, much less attention has been paid to substitutions of endocyclic atoms in aromatic cores through partial disassembly ... mehr

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Correction: Electrowetting without external voltage using paint-on electrodes

Correction for ‘Electrowetting without external voltage using paint-on electrodes’ by Collin B. Eaker et al., Lab Chip, 2017, DOI: 10.1039/c6lc01500j. mehr

Detection of Chemical Warfare Agent Simulants and Hydrolysis Products in Biological Samples by Paper Spray Mass Spectrometry

Paper spray ionization coupled to a high resolution tandem mass spectrometer (a quadrupole orbitrap) was used to identify and quantitate chemical warfare agent (CWA) simulants and their hydrolysis products in blood and urine. Three CWA simulants, dimethyl methylphosphonate (DMMP), trimethyl ... mehr

Device and programming abstractions for spatiotemporal control of active micro-particle swarms

We present a hardware setup and a set of executable commands for spatiotemporal programming and interactive control of a swarm of self-propelled microscopic agents inside a microfluidic chip. In particular, local and global spatiotemporal light stimuli are used to direct the motion of ensem ... mehr

Sodium periodate-mediated conjugation of harringtonine enabling the production of a highly specific monoclonal antibody, and the development of a sensitive quantitative analysi ...

Harringtonine (HT) is a promising natural product that is mainly isolated from plants of the genus Cephalotaxus. Due to its remarkable antileukemic activities, HT has been utilized clinically in China for the treatment of acute promyelocytic leukemia (APL). No antibody that recognizes free ... mehr

Surface plasmon resonance (SPR) imaging for ABH antigens detection of RBCs and saliva: secretor status-related ABO subgroup identification

Low antigenic expression of subgroup ABO blood system on red blood cell (RBC) is cause of discrepancy between forward and reverse blood typing in standard agglutination technique. Neutralization agglutination for detection of ABH substance in saliva is employed for verification. However, ne ... mehr

Alle Fachpublikationen zu Analytik

An efficient noble-metal-free supported copper catalyst for selective nitrocyclohexane hydrogenation to cyclohexanone oxime

It was shown for the first time that cyclohexanone oxime (CHO) can be selectively produced by heterogeneous copper-catalyzed hydrogenative transformation of nitrocyclohexane (NC). The combination of Cu0 and Cu+ and their cooperative interaction with weakly acidic SiO2 supports elicited a si ... mehr

Interpolated energy densities, correlation indicators and lower bounds from approximations to the strong coupling limit of DFT

We investigate the construction of approximated exchange–correlation functionals by interpolating locally along the adiabatic connection between the weak- and the strong-coupling regimes, focussing on the effect of using approximate functionals for the strong-coupling energy densities. The ... mehr

Aromatic metamorphosis: conversion of an aromatic skeleton into a different ring system

Aromatic skeletons are generally regarded as being uncleavable because of their aromatic stabilization energy. Compared to exocyclic functionalizations of aromatic compounds, much less attention has been paid to substitutions of endocyclic atoms in aromatic cores through partial disassembly ... mehr

Improved photodynamic activities of liposome-incorporated [60]fullerene derivatives bearing a polar group

[60]Fullerene (C60) derivatives were incorporated into liposomes using a fullerene exchange method involving the transfer of the fullerene from the cavity of two γ-cyclodextrin molecules to a liposome. A lipid-membrane-incorporated C60 derivative bearing a polar group showed much higher pho ... mehr

Metal-free nitroxyl radical-mediated [small beta]-C(sp3)-H amination of saturated ketones with heteroaryl halides: multiple roles of TEMPO

The first metal-free nitroxyl-radical-mediated β-amination of saturated ketones by using heteroaryl halides as amide precursors has been developed. This reaction proceeds through a cascade α-aminoxylation/Cope-like elimination/aza-Michael addition sequence to afford β-amino ketone derivativ ... mehr

Alle Fachpublikationen zu Chemie

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology Laboratory Investigation advance online publication, March 6 2017. doi:10.1038/labinvest.2017.9 Authors: Akinori Kawakami & David E Fisher mehr

Inside the USCAP Journals

Inside the USCAP Journals Laboratory Investigation 97, 230 (March 2017). doi:10.1038/labinvest.2017.7 mehr

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance

Regression in primary cutaneous melanoma: etiopathogenesis and clinical significance Laboratory Investigation advance online publication, February 27 2017. doi:10.1038/labinvest.2017.8 Authors: Phyu P Aung, Priyadharsini Nagarajan & Victor G Prieto mehr

Drugs with anti-oxidant properties can interfere with cell viability measurements by assays that rely on the reducing property of viable cells

Drugs with anti-oxidant properties can interfere with cell viability measurements by assays that rely on the reducing property of viable cells Laboratory Investigation advance online publication, February 27 2017. doi:10.1038/labinvest.2017.18 Authors: Niraj Shenoy, Mary Stens ... mehr

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing

Identification of microRNAs associated with invasive and aggressive phenotype in cutaneous melanoma by next-generation sequencing Laboratory Investigation advance online publication, February 20 2017. doi:10.1038/labinvest.2017.5 Authors: Sankhiros Babapoor, Rong Wu, James Koz ... mehr

Alle Fachpublikationen zu Labortechnik

Dynamic load on composite laminates in the presence of water

An experimental activity, in order to assess the impact behavior at room and low temperature, of carbon fiber in vinylester resin laminates used in the shipbuilding industry, was conducted. The conditions, which simulate the impact of a tool that drop on the panel mounted on a boat hull in ... mehr

Hydraulic and disinfection efficiency of an ozonation contactor for a municipal water treatment plant using computational fluid dynamics

ABSTRACT Determination of hydrodynamic characteristics and disinfection efficiency are important factors in the operational study of the ozone contactors. In the present work, a full‐scale ozonation contactor for a municipal water treatment plant was simulated by computational fluid dyn ... mehr

Methylene blue adsorption using chabazite: Kinetics and equilibrium modelling

ABSTRACT The adsorption of methylene blue from aqueous solution by a natural zeolite (chabazite) was studied. The effect of adsorbate concentration and pH were evaluated using raw and acid‐treated chabazite. Fourier transform infrared spectroscopy analysis revealed surface modification ... mehr

Development of model systems for in vitro investigation of transdermal transport pathways

Abstract Skin is a complex structured system primarily involved in Transdermal Drug Delivery (TDD). The outer stratum corneum represents the main barrier to the entrance of external molecules. Nowadays, none of the recognized methods, used for the investigation of penetration processes, ... mehr

A binder‐free Ir0.4Ru0.6‐oxide/functionalized multi‐walled carbon nanotube electrode for possible applications in supercapacitors

ABSTRACT An initial study on a simple and inexpensive method to form an Ir0.4Ru0.6‐oxide (MMO) coating onto high‐area plasma functionalized multi‐walled carbon nanotubes (f‐MWCNTs) at the bench‐scale for possible supercapacitor (SC) applications is presented. f‐MWCNT electrodes are prep ... mehr

Alle Fachpublikationen zu Verfahrenstechnik

A review of quantitative structure–property relationships for the fate of ionizable organic chemicals in water matrices and identification of knowledge gaps

Many organic chemicals are ionizable by nature. After use and release into the environment, various fate processes determine their concentrations, and hence exposure to aquatic organisms. In the absence of suitable data, such fate processes can be estimated using Quantitative Structure–Prop ... mehr

Biofilm composition in the Olt River (Romania) reservoirs impacted by chlor-alkali production plant

Freshwater biofilms can be useful indicators of water quality and offer the possibility to assess contaminant effects at the community level. The present field study examines the effect of chlor-alkali plant effluents on the community composition of biofilms grown in Olt River (Romania) res ... mehr

QSARs and computational chemistry methods in environmental chemical sciences

Guest editors Kathrin Fenner and Paul Tratnyek introduce the themed issue on “QSARs and computational chemistry methods in environmental chemical sciences” of Environmental Science: Processes & Impacts. QSARs and computational chemistry methods in environmental chemical sciences mehr

Multi-channel silicone rubber traps as denuders for gas-particle partitioning of aerosols from semi-volatile organic compounds

During many measurements it is important to account for possible changes in the gas-particle distribution of aerosols containing semi-volatile organic compounds (SVOC). If denuders are combined with currently used personal air samplers a simultaneous differential sampling of the gas and par ... mehr

Uranium Mobility and Accumulation along the Rio Paguate, Jackpile Mine in Laguna Pueblo, New Mexico

The mobility and accumulation of uranium (U) along the Rio Paguate, adjacent to the Jackpile Mine, in Laguna Pueblo, New Mexico was investigated using aqueous chemistry, electron microprobe, X-ray diffraction and spectroscopy analyses. Given that it is not common to identify elevated concen ... mehr

Alle Fachpublikationen zu Umwelttechnik
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