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Site-Specific Antibody Modification and Immobilization on a Microfluidic Chip to Promote Capture of Circulating Tumor Cells and Microemboli

We have designed and synthesized EpCAM antibodies with Fc-domain site-specific linkers in allowing preferential alignment when coated on microfluidic device for capturing circulating tumor cells (CTCs) from colorectal cancer patients. The aligned coating has shown to increase capture efficiency of CTCs and m

Autoren:   Chian-Hui Lai; Syer Choon Lim; Liang-Chun Wu; Chien-Fang Wang; Wen-Sy Tsai; Han-Chung Wub; Ying-Chih Chang
Journal:   Chemical Communication
DOI:   10.1039/C7CC00247E
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