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51.641 Aktuelle Fachpublikationen aus der Branche Analytik

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Direct-Laser-Writing of Three-Dimensional Porous Graphene Frameworks on Indium-Tin Oxide for Sensitive Electrochemical Biosensing

20.06.2018 | Qing Hong; Limin Yang; Lei Ge; Zhenhui Liu; Feng Li, Analyst, 2018

The fabrication of graphene electrode with three-dimensional (3D) porous architecture would be highly desirable for electrochemical (bio-)sensing. Direct-laser-writing (DLW) on polyimide sheet has been recognized as an advance approach to pattern 3D porous graphene frameworks (3DPGFs)-based ...

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Integrated strategy for high-sensitive phosphoproteome analysis from low micrograms of protein samples

20.06.2018 | Wendong Chen; Lan Chen; Ruijun Tian, Analyst, 2018

Phosphoproteomics has become popular proteomic technology for exploring cellular signaling networks. However, current approaches often require milligrams of protein samples which hamper their applications for translational purpose with limited starting materials. In this study, we aimed to ...

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A high-throughput multi-microfluidic crystal generator (MMicroCryGen) platform for facile screening of polymorphism and crystals morphology for pharmaceutical compounds

20.06.2018 | Elena Simone; James McVeigh; Nuno M Reis; Zoltan Nagy, Lab on a Chip, 2018

In this work a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, enabling the generation of single crystals and fast and easy screening for polymorphism and crystal habit of solid compounds without any complex fluid handling. The MMicroCryGen device allows ...

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Rapid “turn-on” photoluminescence detection of bisulfite in wines and living cells with formyl bearing bis-cyclometalated Ir(III) complex

20.06.2018 | Hongfang Gao; Hetong Qi; Yijin Peng; Honglan Qi; Chengxiao Zhang, Analyst, 2018

A new photoluminescence (PL) probe based on formyl bearing bis-cyclometalated Ir(III) complex, [Ir(ppy)2phen-CHO]+PF6- (1), is synthesized and applied to selective detection of bisulfite anion (HSO3-). The probe 1 is prepared by using 2-phenylpyridine (ppy) as C^N main ligand and ...

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Direct Label-Free Imaging of Brain Tissue using Synchrotron Light: A Review of New Spectroscopic Tools for the Modern Neuroscientist

20.06.2018 | M. Jake Pushie; Michael E Kelly; Mark Hackett, Analyst, 2018

The incidence of brain disease and brain disorders is increasing on a global scale. Unfortunately, development of new therapeutic strategies has not increased at the same rate, and brain diseases and brain disorders now inflict substantial health and economic impacts. A greater understanding of ...

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Optical Assays Based on Colloidal Inorganic Nanoparticles

20.06.2018 | Amir Ghasemi; Navid Rabiee; Sepideh Ahmadi; shabnam hashemzadeh; Farshad Lolasi; Mashnaz Borzogomid; Alireza Kalbas ..., Analyst, 2018

Colloidal inorganic nanoparticles have wide applications in the detection of analytes and in biological assays. A large number of these assays rely on the ability of gold nanoparticles (AuNPs, in the 20-nm diameter size range) to undergo a color change from red to blue upon aggregation. AuNP ...

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Highly sensitive detection of nucleic acids using cascade amplification strategy based on exonuclease III-assisted target recycling and conjugated polyelectrolytes

20.06.2018 | Biqing Bao; Yanrui Pan; Binbin Gu; Jia Chen; Yu Xu; Peng Su; Yunfei Liu; Li Tong; Lian-Hui Wang, Analyst, 2018

In this paper, a novel ratiometric and cascade amplification strategy was developed by combing the unique signal amplification and effecitive fluorescence resonance energy transfer (FRET) property of conjugated polymers with Exo III-assisted target recycling method. The target DNA (ssDNAc) could ...

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Early and rapid detection of UCHL1 in the serum of brain-trauma patients: a novel gold nanoparticle-based method for diagnosing the severity of brain injury

20.06.2018 | Gyaninder Pal Singh; Richa Nigam; Gaurav Singh Tomar; Mohan Monisha; Sanjeev Kumar Bhoi; Arulselvi S; Kangana Sengar ..., Analyst, 2018

The clinical diagnosis of traumatic brain injury (TBI) is based on neurological examination and neuro-imaging tools such as CT scanning and MRI. However, neurological examination at times may be confounded by consumption of alcohol or drugs and neuroimaging facilities may not be available at all ...

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Anti-thrombotic strategies for microfluidic blood processing

20.06.2018 | Keith Wong; Jon Edd; Shannon Tessier; Will D. Moyo; Baris Mutlu; Lauren D. Bookstaver; Kathleen L. Miller; Stefan He ..., Lab on a Chip, 2018

The redundant mechanisms involved in blood coagulation are crucial for rapid hemostasis. Yet they also create challenges in blood processing in medical devices and lab-on-a-chip systems. In this work, we investigate the effects of both shear stress and hypothermic blood storage on thrombus ...

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Investigating the Autophagic Pathway in Silver@Gold Core Shell Nanoparticles-Treated Cells Using Surface-Enhanced Raman Scattering

20.06.2018 | Yuqing Hou; Wen Zhang; Sheng tao Li; Zhen Wang; Huiqing Zhong; Zhiming Liu; Zhouyi Guo, Analyst, 2018

Previous studies have shown that nanoparticles can induce autophagy, and the main approach for investigating autophagy induced by nanoparticles is through traditional methods such as TEM and biochemical assay. These measurements suffer from the problems of complicated experimental processes or ...

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