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526 Aktuelle Fachpublikationen aus der Branche Labortechnik

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Lack of plakoglobin impairs integrity and wound healing in corneal epithelium in mice

25.05.2018 | Masahide Kokado; Masayasu Miyajima; Yuka Okada; Kana Ichikawa; Osamu Yamanaka; Chia-Yang Liu; Winston Whei-Yang Kao; ..., Laboratory Investigation, 2018

We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ...

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Lack of plakoglobin impairs integrity and wound healing in corneal epithelium in mice

25.05.2018 | Masahide Kokado; Masayasu Miyajima; Yuka Okada; Kana Ichikawa; Osamu Yamanaka; Chia-Yang Liu; Winston Whei-Yang Kao; ..., Laboratory Investigation, 2018

We generated cornea-specific plakoglobin (Jup; junctional plakoglobin) knockout mice in order to investigate the function of plakoglobin on the maintenance of the homeostasis of corneal epithelium in mice. Cornea epithelium-specific conditional knockouts (Jup CEΔ/CEΔ ...

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Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling

23.05.2018 | Jessica Davis-Knowlton; Jacqueline E. Turner; Anna Turner; Sydney Damian-Loring; Nicholas Hagler; Terry Henderson; I ..., Laboratory Investigation, 2018

Atherosclerosis is the most common cause of heart disease and stroke. The use of animal models has advanced our understanding of the molecular signaling that contributes to atherosclerosis. Further understanding of this degenerative process in humans will require human tissue. Plaque removed ...

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Dipeptidyl peptidase IV (DPP-4) inhibition alleviates pulmonary arterial remodeling in experimental pulmonary hypertension

22.05.2018 | Jian Xu; Jingjing Wang; Mengyu He; Honghao Han; Weiping Xie; Hong Wang; Hui Kong, Laboratory Investigation, 2018

Dipeptidyl peptidase IV (DPP-4) is well known for its role in glucose homeostasis, and DPP-4 inhibitor (DPP-4i) exhibits multiple actionsin cardiovascular diseases. However, the effect of DPP-4i on pulmonary hypertension (PH) remains unclear. Therefore, this study aims to investigate the effect ...

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S100A4 protects mice from high-fat diet-induced obesity and inflammation

22.05.2018 | Shasha Hou; Ying Jiao; Qi Yuan; Junfeng Zhai; Tian Tian; Kaiji Sun; Zhinan Chen; Zhenlong Wu; Jinhua Zhang, Laboratory Investigation, 2018

As a member from S100 calcium-binding protein family, S100A4 is ubiquitous and elevated in tumor progression and metastasis, but its role in regulating obesity has not been well characterized. In this study, we showed that S100A4 was mainly expressed by stromal cells in adipose tissue and the ...

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BMP-2 restoration aids in recovery from liver fibrosis by attenuating TGF-β1 signaling

22.05.2018 | Yueh-Hua Chung; Ying-Hsien Huang; Tien-Huei Chu; Chun-Lin Chen; Pey-Ru Lin; Shih-Chung Huang; Deng-Chyang Wu; Chao-C ..., Laboratory Investigation, 2018

Transforming growth factor-β (TGF-β) plays a central role in hepatic fibrogenesis. This study investigated the function and mechanism of bone morphogenetic protein-2 (BMP-2) in regulation of hepatic fibrogenesis. BMP-2 expression in fibrotic liver was measured in human tissue microarray and mouse ...

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Hyaluronan negatively regulates vascular calcification involving BMP2 signaling

21.05.2018 | Yonglun Kong; Qingchun Liang; Yanting Chen; Pingzhen Yang; Xiaoyu Liu; Yining Li; Siyuan Feng; Ji Wu; Wantao Liu; Ji ..., Laboratory Investigation, 2018

Vascular calcification is a highly regulated biological process similar to bone formation involving osteogenic differentiation of vascular smooth muscle cells (VSMCs). Hyaluronan (HA), a major structural component of the extracellular matrix in cartilage, has been shown to inhibit osteoblast ...

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Involvement of inhibitor kappa B kinase 2 (IKK2) in the regulation of vascular tone

21.05.2018 | Youngin Kwon; Soo-Kyoung Choi; Seonhee Byeon; Young-Ho Lee, Laboratory Investigation, 2018

Inhibitor kappa B kinase 2 (IKK2) plays an essential role in the activation of nuclear factor kappa B (NF-kB). Recently, it has been suggested that IKK2 acts as a myosin light chain kinase (MLCK) and contributes to vasoconstriction in mouse aorta. However, the underlying mechanisms are still ...

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The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma

21.05.2018 | Hui-Ta Wu; Cheng-Rong Xie; Jie Lv; He-Qiang Qi; Fei Wang; Sheng Zhang; Qin-Liang Fang; Fu-Qiang Wang; Yu-Yan Lu; Zhe ..., Laboratory Investigation, 2018

Downregulation of deleted in liver cancer 1 (DLC1) is associated with poor prognosis of various cancers, but its functional mechanisms in hepatocellular carcinoma (HCC) remains unclear. In the present study, we investigated the roles of DLC1 in tumor progression and autophagy of HCC. We found ...

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Mutation screening using formalin-fixed paraffin-embedded tissues: a stratified approach according to DNA quality

16.05.2018 | Francesco Cucco; Alexandra Clipson; Hannah Kennedy; Joe Sneath Thompson; Ming Wang; Sharon Barrans; Moniek van Hoppe ..., Laboratory Investigation, 2018

DNA samples from formalin-fixed paraffin-embedded tissues are highly degraded with variable quality, and this imposes a big challenge for targeted sequencing due to false positives, largely caused by PCR errors and cytosine deamination. To eliminate false positives, a common practice is to ...

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