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474 Aktuelle Fachpublikationen aus der Branche Labortechnik

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Mutation screening using formalin-fixed paraffin-embedded tissues: a stratified approach according to DNA quality

16.05.2018 | Francesco Cucco; Alexandra Clipson; Hannah Kennedy; Joe Sneath Thompson; Ming Wang; Sharon Barrans; Moniek van Hoppe ..., Laboratory Investigation, 2018

DNA samples from formalin-fixed paraffin-embedded tissues are highly degraded with variable quality, and this imposes a big challenge for targeted sequencing due to false positives, largely caused by PCR errors and cytosine deamination. To eliminate false positives, a common practice is to ...

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Establishment of a nasopharyngeal carcinoma cell line capable of undergoing lytic Epstein–Barr virus reactivation

16.05.2018 | Yim Ling Yip; Weitao Lin; Wen Deng; Lin Jia; Kwok Wai Lo; Pierre Busson; Benjamin Vérillaud; Xuefeng Liu; Chi M ..., Laboratory Investigation, 2018

Epstein–Barr virus (EBV) infects more than 90% of the adult human population. Undifferentiated nasopharyngeal carcinoma (NPC) is common in Southeast Asia, with a particularly high incidence among southern Chinese. The EBV genome can be detected in practically all cancer cells in undifferentiated ...

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Nanovesicle-mediated delivery of anticancer agents effectively induced cell death and regressed intrahepatic tumors in athymic mice

10.05.2018 | Joseph George; Irene K. Yan; Tushar Patel, Laboratory Investigation, 2018

Hepatocellular carcinoma is highly resistant to chemotherapy. Here we evaluated the use and efficacy of milk-derived nanovesicles (MNV) as an approach to improve delivery of anticancer agents into HCC cells and intrahepatic tumors. We developed a protocol for isolation of MNVs from skim milk ...

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Identification of inhibitors regulating cell proliferation and FUS-DDIT3 expression in myxoid liposarcoma using combined DNA, mRNA, and protein analyses

27.03.2018 | David Svec; Soheila Dolatabadi; Christer Thomsen; Nicole Cordes; Mark Shannon; Paul Fitzpatrick; Göran Landberg ..., Laboratory Investigation, 2018

FUS-DDIT3 belongs to the FET (FUS, EWSR1, and TAF15) family of fusion oncogenes, which collectively are considered to be key players in tumor development. Even though over 90% of all myxoid liposarcomas (MLS) have a FUS-DDIT3 gene fusion, there is limited understanding of the signaling pathways ...

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Restoration of E-cadherin by PPBICA protects against cisplatin-induced acute kidney injury by attenuating inflammation and programmed cell death

26.03.2018 | Li Gao; Ming-Ming Liu; Hong-mei Zang; Qiu-Ying Ma; Qin Yang; Ling Jiang; Gui-Ling Ren; Hai-Di Li; Wei-Feng Wu; Jia-n ..., Laboratory Investigation, 2018

E-cadherin is a major component of tubular adherent proteins that maintain intercellular contacts and cell polarity in epithelial tissue. It is involved in pathological processes of renal cell carcinoma and fibrotic diseases via epithelial–mesenchymal transition. Although studies have shown ...

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Reduced expression of the H19 long non-coding RNA inhibits pancreatic cancer metastasis

26.03.2018 | Hisashi Yoshimura; Yoko Matsuda; Masami Yamamoto; Masaki Michishita; Kimimasa Takahashi; Norihiko Sasaki; Naoshi Ish ..., Laboratory Investigation, 2018

H19 is an oncofetal RNA expressed in the developing embryo as well as in bladder, breast, gastric, pancreatic, hepatocellular, and prostate cancers. Recent studies have shown that H19 enhances cancer invasion and metastasis; however, its roles in cancer remain controversial. In the current study, ...

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Heparin-binding epidermal growth factor contributes to COPD disease severity by modulating airway fibrosis and pulmonary epithelial–mesenchymal transition

26.03.2018 | Tianwen Lai; Yanyu Li; Min Chen; Guihai Pan; Xiaoxia Wen; Zongjiong Mai; Yalian Yuan; Yingying Lv; Quanchao Lv; Ruil ..., Laboratory Investigation, 2018

Although airway fibrosis and epithelial–mesenchymal transition (EMT) contribute to airway remodeling in chronic obstructive pulmonary disease (COPD), the mechanisms underlying their development have not been fully elucidated. In the present study, we aimed to assess heparin-binding epidermal ...

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A single high-fat meal provokes pathological erythrocyte remodeling and increases myeloperoxidase levels: implications for acute coronary syndrome

23.03.2018 | Tyler W Benson; Neal L Weintraub; Ha Won Kim; Nichole Seigler; Sanjiv Kumar; Jonathan Pye; Tetsuo Horimatsu; Rod Pel ..., Laboratory Investigation, 2018

High-fat meal (HFM) consumption can produce acute lipemia and trigger myocardial infarction in patients with atherosclerosis, but the mechanisms are poorly understood. Erythrocytes (red blood cells, RBCs) intimately interact with inflammatory cells and blood vessels and play a complex role in ...

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Lack of hepatic stimulator substance expression promotes hepatocellular carcinoma metastasis partly through ERK-activated epithelial–mesenchymal transition

01.03.2018 | Xiao-wei Jia; Zi-wei Li; Ling-yue Dong; Guang-yong Sun; Xin Wang; Jian Gao; Yi-peng Li; Yuan Wu; Wei An, Laboratory Investigation, 2018

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies due to its high frequency of metastasis via the epithelial–mesenchymal transition (EMT) pathway. Hepatic stimulator substance (HSS) can protect hepatocytes from injury and promote liver growth. Recent studies indicated that HSS ...

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Pirfenidone reduces profibrotic responses in human dermal myofibroblasts, in vitro

01.03.2018 | Caroline L. Hall; Adrienne R. Wells; Kai P. Leung, Laboratory Investigation, 2018

Pirfenidone (PFD) is a synthetic small molecule inhibitor with demonstrated anti-inflammatory and antifibrotic properties in vitro and in vivo. The exact mechanism(s) of PFD action remain unclear, due in part to the broad effects of this drug on the complex processes involved in inflammation and ...

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