10.04.2013 | Liu, Jianhua; Xin, Rui; Li, Zhiman; Golamaully, Reza; Zhang, Yan; Zhang, Jishen; Yuan, Qinghai; Liu, Xiaodong, Current Topics in Medicinal Chemistry, 2013

Abstract: X-ray computed tomography (CT), an efficient non-invasive clinical technique, usually provides highresolution 3D structure details of tissues in early disease diagnosis. Here, we report a high-performance CT imaging platform based on a monodispersed Yb-based nanoparticulate ...

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10.04.2013 | Kim, Eunjoo; Lee, Se Geun; Kim, Hyun-Chul; Lee, Sung Jun; Baek, Chul Su; Jeong, Sang Won, Current Topics in Medicinal Chemistry, 2013

Abstract: The preparation of a synthetic receptor for multivalent protein binding by a directed immobilization of bifunctional ligands was demonstrated using pentameric C-reactive protein (CRP) and a thiolated phosphocholine-containing ligand on a gold surface. CRP consisting of five ...

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10.04.2013 | Lee, Jung Hwan, Current Topics in Medicinal Chemistry, 2013

Abstract: The development of imaging probes based on advances in nanotechnology aims to substantially improve specificity and sensitivity of diagnostic imaging through non-invasive and quantitative detection of specific biomolecules in living subjects. A promising class of molecular ...

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10.04.2013 | Kim, Kyoung-Min; Kang, Joo-Hee; Vinu, Ajayan; Choy, Jin-Ho; Oh, Jae-Min, Current Topics in Medicinal Chemistry, 2013

Abstract: In this review, we are going to demonstrate the recent progresses in inorganic nanomaterial-based nanomedicines and their labeling for effective biological imaging. Nanomaterials which are classified according to their dimensionality, from zero- to three-dimensions can be ...

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10.04.2013 | Vugts, Danielle J.; Visser, Gerard W.M.; van Dongen, Guus A.M.S., Current Topics in Medicinal Chemistry, 2013

Abstract: Positron emission tomography with 89Zr can be used to follow the behaviour of therapeutic monoclonal antibodies (mAbs) and other biologicals in vivo. The favourable radiophysical characteristics of 89Zr allow multiple days PET scanning after injection. For the coupling of ...

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10.04.2013 | Jeong Kim, Tae; Seok Chae, Kwon; Chang, Yongmin; Ho Lee, Gang, Current Topics in Medicinal Chemistry, 2013

Abstract: Potentials of hydrophilic and biocompatible ligand coated gadolinium oxide nanoparticles as multimodal imaging agents, drug carriers, and therapeutic agents are reviewed. First of all, they can be used as advanced T1 magnetic resonance imaging (MRI) contrast agents because ...

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10.04.2013 | Guo, Yunjun; Aweda, Tolulope; Black, Kvar C.L.; Liu, Yongjian, Current Topics in Medicinal Chemistry, 2013

Abstract: Labeling nanoparticles with radionuclides has been widely used to form multifunctional and multivalency agents for various biomedical applications. A variety of nanostructures including inorganic, organic and lipid nanoparticles have been labeled with positron or gamma ...

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10.04.2013 | A Sasser, Todd; E Van Avermaete, Ashley; White, Alexander; Chapman, Sarah; R Johnson, James; Van Avermaete, Tony; T ..., Current Topics in Medicinal Chemistry, 2013

Abstract: At present, a limited number of strategies exist for diagnostic imaging of patients with bacterial infection. While radiolabeled probes and white blood cells provide robust solutions to detect bacteria in humans, they also give false positives in cases of sterile ...

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10.04.2013 | Chang, Yongmin; Ho Lee, Gang; Kim, Tae-Jeong; Chae, Kwon-Seok, Current Topics in Medicinal Chemistry, 2013

Abstract: Magnetic resonance imaging (MRI) contrast agents have been used routinely for more than 20 years in order to increase sensitivity and specificity of lesion detection. MRI contrast agents (CAs) are usually categorized according to their magnetic behavior, biodistribution, and ...

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10.04.2013 | Huang, Ching-Hui; Tsourkas, Andrew, Current Topics in Medicinal Chemistry, 2013

Abstract: As we move towards an era of personalized medicine, molecular imaging contrast agents are likely to see an increasing presence in routine clinical practice. Magnetic resonance (MR) imaging has garnered particular interest as a platform for molecular imaging applications due ...

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