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1.908 Aktuelle Fachpublikationen von Cold Spring Harbor Laboratory Press


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[Developmental Biology] Signaling Networks in Epithelial Tube Formation

01.12.2017 | Ilenia Bernascone; Mariam Hachimi; Fernando Martin-Belmonte, CSH Perspectives, 2017

Epithelial tubes are crucial to the function of organ systems including the excretory, gastrointestinal, cardiovascular, and pulmonary. Studies in the last two decades using in vitro organotypic systems and a variety of animal models have substantiated a large number of the morphogenetic ...


[Biomedical Foundations] Leaving the Bench and Finding Your Foundation

01.12.2017 | John E. Spiro, CSH Perspectives, 2017

Scientists who leave the laboratory bench to work for biomedical foundations mobilize and focus resources on the most promising research behind a foundation's mission. They acquire a broad view of a field, interact closely with research scientists at meetings and laboratory visits, and often ...


[Cell Biology] Minimal Cells--Real and Imagined

01.12.2017 | John I. Glass; Chuck Merryman; Kim S. Wise; Clyde A. Hutchison III; Hamilton O. Smith, CSH Perspectives, 2017

A minimal cell is one whose genome only encodes the minimal set of genes necessary for the cell to survive. Scientific reductionism postulates the best way to learn the first principles of cellular biology would be to use a minimal cell in which the functions of all genes and components are ...


[Chronobiology] A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms

01.12.2017 | Michael Rosbash, CSH Perspectives, 2017

I worked almost exclusively on nucleic acids and gene expression from the age of 19 as an undergraduate until the age of 38 as an associate professor. Mentors featured prominently in my choice of paths. My friendship with influential Brandeis colleagues then persuaded me that genetics was an ...


[Cell Biology] Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin

01.12.2017 | Elly M. Hol; Yassemi Capetanaki, CSH Perspectives, 2017

Type III intermediate filament (IF) proteins assemble into cytoplasmic homopolymeric and heteropolymeric filaments with other type III and some type IV IFs. These highly dynamic structures form an integral component of the cytoskeleton of muscle, brain, and mesenchymal cells. Here, we review the ...


[Immunology] What Is Wrong with Pertussis Vaccine Immunity?: Why Immunological Memory to Pertussis Is Failing

01.12.2017 | Dimitri A. Diavatopoulos; Kathryn Margaret Edwards, CSH Perspectives, 2017

Memory responses seen after whole-cell pertussis (wP) and acellular pertussis (aP) vaccine priming are different and reflect better long-term protection against pertussis disease seen with the whole-cell vaccines. Although acellular vaccines generate higher levels of antigen-specific IgG to the ...


[Cell Biology] Polarized Exocytosis

01.12.2017 | Jingwen Zeng; Shanshan Feng; Bin Wu; Wei Guo, CSH Perspectives, 2017

Polarized exocytosis is generally considered as the multistep vesicular trafficking process in which membrane-bounded carriers are transported from the Golgi or endosomal compartments to specific sites of the plasma membrane. Polarized exocytosis in cells is achieved through the coordinated ...


[Immunology] What Is Wrong with Pertussis Vaccine Immunity?: The Problem of Waning Effectiveness of Pertussis Vaccines

01.12.2017 | Nicolas Burdin; Lori Kestenbaum Handy; Stanley A. Plotkin, CSH Perspectives, 2017

Pertussis is resurgent in some countries, particularly those in which children receive acellular pertussis (aP) vaccines in early infancy and boosters later in life. Immunologic studies show that, whereas whole-cell pertussis (wP) vaccines orient the immune system toward Th1/Th17 responses, ...


[Molecular Pathology] TGF-{beta} Family Signaling in Tumor Suppression and Cancer Progression

01.12.2017 | Joan Seoane; Roger R. Gomis, CSH Perspectives, 2017

Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the cellular context and its integration with other signaling pathways. In cancer, the pleiotropic reaction to TGF-β leads to a diverse and varied set of gene responses that range from cytostatic and apoptotic ...


[Immunology] What Is Wrong with Pertussis Vaccine Immunity?: Inducing and Recalling Vaccine-Specific Immunity

01.12.2017 | Christiane S. Eberhardt; Claire-Anne Siegrist, CSH Perspectives, 2017

The high incidence of pertussis in vaccinated adolescents suggests the failing of immune memory. We argue that acellular pertussis vaccines generate memory cells that are effectively reactivated by boosters better than by Bordetella pertussis exposure. We propose that there are two main causes. ...


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