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28.727 Aktuelle Fachpublikationen von Proceedings of the National Academy of Sciences

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Sequential activation of human signal recognition particle by the ribosome and signal sequence drives efficient protein targeting [Biochemistry]

12.06.2018 | Jae Ho Lee; Sowmya Chandrasekar; SangYoon Chung; Yu-Hsien Hwang Fu; Demi Liu; Shimon Weiss; Shu-ou Shan, Proceedings of the National Academy of Sciences current issue, 2018

The universally conserved signal recognition particle (SRP) delivers ∼30% of the proteome to the appropriate cellular membrane. How SRP achieves efficient and selective protein targeting in eukaryotes remains elusive. Here, we show that a functional signal sequence on the nascent polypeptide ...

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Comprehensive phylogeny of ray-finned fishes (Actinopterygii) based on transcriptomic and genomic data [Evolution]

12.06.2018 | Lily C. Hughes; Guillermo Ortí; Yu Huang; Ying Sun; Carole C. Baldwin; Andrew W. Thompson; Dahiana Arcila; Ricardo B ..., Proceedings of the National Academy of Sciences current issue, 2018

Ray-finned fishes form the largest and most diverse group of vertebrates. Establishing their phylogenetic relationships is a critical step to explaining their diversity. We compiled the largest comparative genomic database of fishes that provides genome-scale support for previous phylogenetic ...

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KDM4B protects against obesity and metabolic dysfunction [Medical Sciences]

12.06.2018 | Yingduan Cheng; Quan Yuan; Laurent Vergnes; Xin Rong; Ji Youn Youn; Jiong Li; Yongxin Yu; Wei Liu; Hua Cai; Jiandie ..., Proceedings of the National Academy of Sciences current issue, 2018

Obesity has become a major epidemic around the globe, with fatal comorbidities such as type 2 diabetes, heart disease, and cancer that have led to alarming health concerns in modern medicine. Although excess adipose tissue is associated with negative metabolic outcomes, the physiological ...

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Two-way mixed-effects methods for joint association analysis using both host and pathogen genomes [Statistics]

12.06.2018 | Miaoyan Wang; Fabrice Roux; Claudia Bartoli; Carine Huard-Chauveau; Christopher Meyer; Hana Lee; Dominique Roby; Mar ..., Proceedings of the National Academy of Sciences current issue, 2018

Genome-wide association (GWA) mapping is a powerful tool for identification of genetic variants underlying complex traits. However, existing methods typically perform GWA mapping within a single species; methods allowing the description of the genomic landscape of interspecies interactions are ...

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Functional diversification of Arabidopsis SEC1-related SM proteins in cytokinetic and secretory membrane fusion [Plant Biology]

12.06.2018 | Matthias Karnahl; Misoon Park; Cornelia Krause; Ulrike Hiller; Ulrike Mayer; York-Dieter Stierhof; Gerd Jürgens, Proceedings of the National Academy of Sciences current issue, 2018

Membrane fusion is a fundamental process of eukaryotic cells required for subcellular organization and cell–cell communication, involving SNARE proteins and regulatory Sec1/Munc18 (SM) proteins. In plant cytokinesis, membrane vesicles delivered to the cell-division plane fuse with one another to ...

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In vitro reconstitution of sortase-catalyzed pilus polymerization reveals structural elements involved in pilin cross-linking [Biochemistry]

12.06.2018 | Chungyu Chang; Brendan R. Amer; Jerzy Osipiuk; Scott A. McConnell; I-Hsiu Huang; Van Hsieh; Janine Fu; Hong H. Nguye ..., Proceedings of the National Academy of Sciences current issue, 2018

Gram-positive sortase enzymes represent two broad functional categories—those that cross-link proteins to the cell wall and those that can catalyze this reaction and polymerize proteins to build adhesive pilus fibers. Here we report an in vitro reproduction of a robust pilus polymerization ...

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Fluctuating hydrogen-bond networks govern anomalous electron transfer kinetics in a blue copper protein [Biophysics and Computational Biology]

12.06.2018 | Joshua S. Kretchmer; Nicholas Boekelheide; Jeffrey J. Warren; Jay R. Winkler; Harry B. Gray; Thomas F. Miller, Proceedings of the National Academy of Sciences current issue, 2018

Protein fluctuations and hydrogen-bond networks play an important—although incompletely understood—role in facilitating efficient biological electron transfer (ET). Experimental mutagenesis results provide evidence for the role of protein motions in Ru-modified azurin ET, a quintessential example ...

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Increase in chemokine CXCL1 by ER{beta} ligand treatment is a key mediator in promoting axon myelination [Neuroscience]

12.06.2018 | Hawra Karim; Sung Hoon Kim; Andrew S. Lapato; Norio Yasui; John A. Katzenellenbogen; Seema K. Tiwari-Woodruff, Proceedings of the National Academy of Sciences current issue, 2018

CXCL1 is a major neutrophil chemoattractant that binds to the chemokine receptor, CXCR2, on neutrophils and oligodendrocytes. Estrogen receptor β ligand treatment in a mouse model of multiple sclerosis induces an increase in peripheral and brain CXCL1 levels that correlate with an increase in ...

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An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics [Biophysics and Computational Biology]

12.06.2018 | Florian Blanc; Tatiana Isabet; Hannah Benisty; H. Lee Sweeney; Marco Cecchini; Anne Houdusse, Proceedings of the National Academy of Sciences current issue, 2018

Myosins are motor proteins involved in the transport of cellular cargoes and muscle contraction. Upon interaction with actin, the motor domain undergoes a conformational transition, called powerstroke, in which the lever arm is swung to generate force and directional motion. The recovery stroke ...

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Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1 [Applied Biological Sciences]

12.06.2018 | Junpeng Qi; Xiuling Li; Haiyong Peng; Erika M. Cook; Eman L. Dadashian; Adrian Wiestner; HaJeung Park; Christoph Rader, Proceedings of the National Academy of Sciences current issue, 2018

Harnessing and enhancing the innate and adaptive immune system to fight cancer represents one of the most promising strategies in contemporary cancer therapy. Although bispecific antibodies (biAbs) that combine a T cell-engaging arm with a tumor cell-binding arm are particularly potent cancer ...

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