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234.232 Aktuelle Fachpublikationen von WILEY

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The unfolding landscape of the congenital myasthenic syndromes

21.01.2018 | Andrew G. Engel, Xin‐Ming Shen, Duygu Selcen, Annals of the New York Academy of Sciences, 2018

Abstract Congenital myasthenic syndromes (CMS) are heterogeneous disorders in which the safety margin of neuromuscular transmission is impaired by one or more specific mechanisms. Since the advent of next‐generation sequencing methods, the discovery of novel CMS targets and phenotypes has ...

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Passive transfer models of myasthenia gravis with muscle‐specific kinase antibodies

21.01.2018 | Jan J.G.M. Verschuuren, Jaap J. Plomp, Steve J. Burden, Wei Zhang, Yvonne E. Fillié‐Grijpma, Inge E. Stienstra‐van E ..., Annals of the New York Academy of Sciences, 2018

Abstract Myasthenia gravis (MG) with antibodies to muscle‐specific kinase (MuSK) is characterized by fluctuating fatigable weakness. In MuSK MG, involvement of bulbar muscles, neck, and shoulder and respiratory weakness are more prominent than in acetylcholine receptor (AChR) MG. MuSK ...

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Acetylcholine receptor antibody–mediated animal models of myasthenia gravis and the role of complement

21.01.2018 | Linda L. Kusner, Manjistha Sengupta, Henry J. Kaminski, Annals of the New York Academy of Sciences, 2018

Abstract Because of the failure of many promising therapeutics identified in preclinical evaluation, funding sources have established guidelines for increased rigor in animal evaluations. The myasthenia gravis (MG) community of scientists has developed guidelines for preclinical assessment for ...

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Functions of autophagy in the tumor microenvironment and cancer metastasis

21.01.2018 | Erin E. Mowers, Marina N Sharifi, Kay F. MacLeod, FEBS Journal, 2018

Abstract Macro‐autophagy is an ancient and highly‐conserved self‐degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens and protein aggregates. Autophagy, as it is routinely referred to, also allows cells to maintain metabolic sufficiency and ...

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Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix‐assisted laser desorption‐ionization‐mass spectrometry imaging (MALDI‐MSI)

21.01.2018 | E. E. L. Lewis, M. R. T. Barrett, L. Freeman‐Parry, R. A. Bojar, M. R. Clench, International Journal of Cosmetic Science, 2018

Abstract Objective Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix‐assisted laser desorption/ionization‐mass spectrometry imaging (MALDI‐MSI) to identify lipids directly involved as potential biomarkers. These biomarkers may ...

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Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix‐assisted laser desorption‐ionization‐mass spectrometry imaging (MALDI‐MSI)

21.01.2018 | E. E. L. Lewis, M. R. T. Barrett, L. Freeman‐Parry, R. A. Bojar, M. R. Clench, International Journal of Cosmetic Science, 2018

Abstract Objective Examination of the skin barrier repair/wound healing process using a living skin equivalent (LSE) model and matrix‐assisted laser desorption/ionization‐mass spectrometry imaging (MALDI‐MSI) to identify lipids directly involved as potential biomarkers. These biomarkers may ...

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Atomic Layer Deposition Fabricating of Ceramic Nanofiltration Membranes for Efficient Separation of Dyes from Water

21.01.2018 | He Chen, Shanshan Wu, Xiaojuan Jia, Sen Xiong, Yong Wang, AIChE Journal, 2018

Abstract To meet the strong need for highly efficient and controllable manufacturing methods to ceramic nanofiltration (NF) membranes, we use atomic layer deposition (ALD) to prepare NF membranes by tightening ultrafiltration (UF) membranes. We confine the ALD deposition of TiO2 to the ...

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Real‐time Multi‐Variable Model Predictive Control (MPC) for Steam‐Assisted Gravity Drainage (SAGD)

21.01.2018 | Sagar N Purkayastha, Ian D. Gates, Milana Trifkovic, AIChE Journal, 2018

Abstract Thermal recovery techniques, such as Steam‐Assisted Gravity Drainage (SAGD), is used to recover the majority of the crude bitumen, in Western Canada. However, suboptimal production techniques have led to a large carbon footprint and a subsequent search for more efficient extraction ...

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High‐Temperature Mechanical Behavior of ZrB2‐Based Composites with Micron‐ and Nano‐Sized SiC Particles

21.01.2018 | Shuqi Guo, Journal of the American Ceramic Society, 2018

Abstract Using micron‐ and nano‐sized SiC particles as reinforcement phase, two ZrB2‐SiC composites with high strength up to 1600°C were prepared using high‐energy ball‐milling, followed by hot‐pressing. The composite microstructure comprised finer equiaxed ZrB2 and SiC grains and ...

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Role of oxygen vacancies in long persistent phosphor Ca2Ga2GeO7: Zn2+

20.01.2018 | Junhe Zhou, Zhangwen Long, Qi Wang, Zhou Dacheng, Xuhui Xu, Jianbei Qiu, Journal of the American Ceramic Society, 2018

Abstract Acting as the electron trap, oxygen vacancies can strongly influence the long persistent luminescence (LPL) properties were verified in Ca2Ga2GeO7: Zn2+ (CGGZ) phosphor. The existence of oxygen vacancies in this self‐excitation material was confirmed by a simple fluorescence probe ...

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