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229 Aktuelle Fachpublikationen in Annual Review of Analytical Chemistry

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The Coupled Chemical and Physical Dynamics Model of MALDI

15.06.2016 | Richard Knochenmuss, Annual Review of Analytical Chemistry, 2016

The coupled physical and chemical dynamics model of ultraviolet matrix-assisted laser desorption/ionization (MALDI) has reproduced and explained a wide variety of MALDI phenomena. The rationale behind and elements of the model are reviewed, including the photophysics, kinetics, and thermodynamics ...

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Advances in Mid-Infrared Spectroscopy for Chemical Analysis

15.06.2016 | Julian Haas; Boris Mizaikoff, Annual Review of Analytical Chemistry, 2016

Infrared spectroscopy in the 3–20 μm spectral window has evolved from a routine laboratory technique into a state-of-the-art spectroscopy and sensing tool by benefitting from recent progress in increasingly sophisticated spectra acquisition techniques and advanced materials for generating, ...

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Progress in Top-Down Proteomics and the Analysis of Proteoforms

15.06.2016 | Timothy K. Toby; Luca Fornelli; Neil L. Kelleher, Annual Review of Analytical Chemistry, 2016

From a molecular perspective, enactors of function in biology are intact proteins that can be variably modified at the genetic, transcriptional, or post-translational level. Over the past 30 years, mass spectrometry (MS) has become a powerful method for the analysis of proteomes. Prevailing ...

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Fabrication and Operation of Paper-Based Analytical Devices

15.06.2016 | Xiao Jiang; Z. Hugh Fan, Annual Review of Analytical Chemistry, 2016

This review focuses on the fabrication techniques and operational components of microfluidic paper-based analytical devices (μPADs). Being low-cost, user-friendly, fast, and simple, μPADs have seen explosive growth in the literature in the last decade. Many different materials and technologies ...

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Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge

15.06.2016 | Jody C. May; John A. McLean, Annual Review of Analytical Chemistry, 2016

Hybrid analytical instrumentation constructed around mass spectrometry (MS) is becoming the preferred technique for addressing many grand challenges in science and medicine. From the omics sciences to drug discovery and synthetic biology, multidimensional separations based on MS provide the high ...

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Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry

15.06.2016 | Qiuling Zheng; Hao Chen, Annual Review of Analytical Chemistry, 2016

Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent advance in the field of analytical chemistry. This review surveys the development of liquid sample DESI-MS (LS-DESI-MS), a variant form of DESI-MS that focuses on fast analysis of liquid samples, and its novel analy-tical ...

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Plant Molecular Farming: Much More than Medicines

15.06.2016 | Marc Tschofen; Dietmar Knopp; Elizabeth Hood; Eva Stöger, Annual Review of Analytical Chemistry, 2016

Plants have emerged as commercially relevant production systems for pharmaceutical and nonpharmaceutical products. Currently, the commercially available nonpharmaceutical products outnumber the medical products of plant molecular farming, reflecting the shorter development times and lower ...

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In Situ and In Vivo Molecular Analysis by Coherent Raman Scattering Microscopy

15.06.2016 | Chien-Sheng Liao; Ji-Xin Cheng, Annual Review of Analytical Chemistry, 2016

Coherent Raman scattering (CRS) microscopy is a high-speed vibrational imaging platform with the ability to visualize the chemical content of a living specimen by using molecular vibrational fingerprints. We review technical advances and biological applications of CRS microscopy. The basic theory ...

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Glycan Arrays: From Basic Biochemical Research to Bioanalytical and Biomedical Applications

15.06.2016 | Andreas Geissner; Peter H. Seeberger, Annual Review of Analytical Chemistry, 2016

A major branch of glycobiology and glycan-focused biomedicine studies the interaction between carbohydrates and other biopolymers, most importantly, glycan-binding proteins. Today, this research into glycan-biopolymer interaction is unthinkable without glycan arrays, tools that enable ...

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Mass Spectrometry Applied to Bottom-Up Proteomics: Entering the High-Throughput Era for Hypothesis Testing

15.06.2016 | Ludovic C. Gillet; Alexander Leitner; Ruedi Aebersold, Annual Review of Analytical Chemistry, 2016

Proteins constitute a key class of molecular components that perform essential biochemical reactions in living cells. Whether the aim is to extensively characterize a given protein or to perform high-throughput qualitative and quantitative analysis of the proteome content of a sample, liquid ...

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