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2.658 Aktuelle Fachpublikationen in Journal of Cellular Biochemistry

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Localization of palmitoylated and activated G protein α‐subunit in Dictyostelium discoideum

20.01.2018 | Sarah Alamer, Yusuke Kageyama, Robert E. Gundersen, Journal of Cellular Biochemistry, 2018

ABSTRACT Guanine nucleotide‐binding proteins (G proteins) act as molecular switches to regulate many fundamental cellular processes. The lipid modification, palmitoylation, can be considered as a key factor for proper G protein function and plasma membrane localization. In Dictyostelium ...

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Induced cumulus expansion of poor quality buffalo cumulus oocyte complexes by Interleukin‐1beta improves their developmental ability

20.01.2018 | Gaurav Kumar Chaubey, Sandeep Kumar, Manish Kumar, Parul Sarwalia, Arumugam Kumaresan, Sachinandan De, Rakesh Kumar, ..., Journal of Cellular Biochemistry, 2018

Abstract The present study was conceived with the aim of modulating the cumulus expansion characteristics of poor quality (BCB‐) buffalo oocyte complexes (COCs) in order to improve their fertilization outcomes. BCB‐ COCs were subjected to in vitro maturation (IVM) in presence of Interleukin – ...

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Halofuginone‐induced autophagy suppresses the migration and invasion of MCF‐7 cells via regulation of STMN1 and p53

19.01.2018 | Xiaojing Xia, Lei Wang, Xiaojian Zhang, Shan Wang, Lianchen Lei, Likun Cheng, Yanzhao Xu, Yawei Sun, Bolin Hang, Gai ..., Journal of Cellular Biochemistry, 2018

Abstract Traditional Chinese medicines have been recognized as especially promising anticancer agents in modern anticancer research. Halofuginone (HF), an analog of quinazolinone alkaloid extracted from Dichroa febrifuga, is widely used in traditional medicine. However, whether HF inhibits ...

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Halofuginone‐induced autophagy suppresses the migration and invasion of MCF‐7 cells via regulation of STMN1 and p53

19.01.2018 | Xiaojing Xia, Lei Wang, Xiaojian Zhang, Shan Wang, Lianchen Lei, Likun Cheng, Yanzhao Xu, Yawei Sun, Bolin Hang, Gai ..., Journal of Cellular Biochemistry, 2018

Abstract Traditional Chinese medicines have been recognized as especially promising anticancer agents in modern anticancer research. Halofuginone (HF), an analog of quinazolinone alkaloid extracted from Dichroa febrifuga, is widely used in traditional medicine. However, whether HF inhibits ...

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Overexpression of Sirt6 is a novel biomarker of malignant human colon carcinoma

19.01.2018 | Chang‐hui Geng, Chun‐ling Zhang, Jing‐yan Zhang, Ping Gao, Miao He, Yan‐lin Li, Journal of Cellular Biochemistry, 2018

Abstract Sirt family has been reported playing a significant role in the cancer development, especial its deacetylase activity plays a key function, but whether SIRT6 plays a role in mediating tumor epithelial‐mesenchymal transition (EMT) and metastasis in colon cancer has not been explored. ...

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Human T‐lymphotropic virus 1 (HTLV‐1) pathogenesis: A systems virology study

19.01.2018 | Sayed‐Hamidreza Mozhgani, Mohadeseh Zarei‐Ghobadi, Majid Teymoori‐Rad, Talat Mokhtari‐Azad, Mehdi Mirzaie, Mohsen Sh ..., Journal of Cellular Biochemistry, 2018

Abstract The main mechanisms of interaction between Human T‐lymphotropic virus type 1 (HTLV‐1) and its hosts in the manifestation of the related disease including HTLV‐1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and Adult T‐cell leukemia/lymphoma (ATLL) are yet to be ...

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Amino group of salicylic acid exhibits enhanced inhibitory potential against insulin amyloid fibrillation with protective aptitude toward amyloid induced cytotoxicity

19.01.2018 | Masihuz Zaman, Mohsin Vahid Khan, Syed Mohammad Zakariya, Saima Nusrat, Syed Mustapha Meeran, Parvez Alam, Mohammad ..., Journal of Cellular Biochemistry, 2018

Abstract Protein misfolding and aggregation lead to amyloid generation that in turn may induce cell membrane disruption and leads to cell apoptosis. In an effort to prevent or treat amyloidogenesis, large number of studies has been paying attention on breakthrough of amyloid inhibitors. In ...

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The prognostic value of PI3K mutational status in breast cancer: a meta‐analysis

18.01.2018 | Sobhani N., Roviello G., Corona S.P., Scaltriti M., Ianza A., Bortul M., Zanconati F., Generali D., Journal of Cellular Biochemistry, 2018

Abstract Breast cancer (BC) is the second most common cause of cancer‐related deaths in women worldwide. The availability of reliable biomarkers of response/resistance to cancer treatments would benefit patients and clinicians allowing for a better selection of BC patients most likely to ...

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Effects of antioxidants on apoptosis induced by dasatinib and nilotinib in K562 cells

18.01.2018 | Sara Damiano, Serena Montagnaro, Maria Valeria Puzio, Lorella Severino, Ugo Pagnini, Marcella Barbarino, Daniele Ces ..., Journal of Cellular Biochemistry, 2018

Abstract In clinical practice for the treatment of chronic myeloid leukemia, second generation of tyrosine kinase inhibitors such as Nilotinib (NIL) specific and potent inhibitor of the BCR/ABL kinase and Dasatinib (DAS) a inhibitor of BCR/ABL and Src family kinase were developed to ...

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K313, a novel benzoxazole derivative, exhibits anti‐inflammatory properties via inhibiting GSK3β activity in LPS‐induced RAW264.7 macrophages

18.01.2018 | Bo‐Bo Zhao, Hui‐Jie Guo, Yang Liu, Xing‐Yan Luo, Shu‐Xia Yang, Yan‐Tang Wang, Xiao Leng, Chun‐Fen Mo, Qiang Zou, Journal of Cellular Biochemistry, 2018

Abstract Benzoxazole and its derivatives have been widely studied in recent years due to their various biological properties. A previous study has demonstrated that K313 (1H‐indole‐2,3‐dione 3‐(1,3‐benzoxazol‐2‐ylhydrazone)), a novel benzoxazole derivative, inhibits T cell proliferation to ...

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