05.04.2013 | Shucong Ma; Maarten M. J. Smulders; Yana R. Hristova; Jack K. Clegg; Tanya K. Ronson; Salvatore Zarra; Jonathan R. N ..., Journal of the American Chemical Society, 2013

Journal of the American Chemical Society DOI: 10.1021/ja311882h

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05.04.2013 | Jia-Ying Guan; Peter H. J. Keizers; Wei-Min Liu; Frank Löhr; Simon P. Skinner; Edwin A. Heeneman; Harald Schwalbe; M ..., Journal of the American Chemical Society, 2013

Determining the three-dimensional structure of a small molecule–protein complex with weak affinity can be a significant challenge. We present a paramagnetic NMR method to determine intermolecular structure restraints based on pseudocontact shifts (PCSs). Since the ligand must be in fast ...

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05.04.2013 | Xiaobo Pan; Yuanting Su; Xiaoyu Chen; Yue Zhao; Yizhi Li; Jinglin Zuo; Xinping Wang, Journal of the American Chemical Society, 2013

Journal of the American Chemical Society DOI: 10.1021/ja402492u

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05.04.2013 | Darren H. Brouwer; Sylvian Cadars; Juergen Eckert; Zheng Liu; Osamu Terasaki; Bradley F. Chmelka, Journal of the American Chemical Society, 2013

A general protocol is demonstrated for determining the structures of molecularly ordered but noncrystalline solids, which combines constraints provided by X-ray diffraction (XRD), one- and two-dimensional solid-state nuclear magnetic resonance (NMR) spectroscopy, and first-principles quantum ...

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05.04.2013 | Stefan Düsterhöft; Sascha Jung; Chien-Wen Hung; Andreas Tholey; Frank D. Sönnichsen; Joachim Grötzinger; Inken Lorenzen, Journal of the American Chemical Society, 2013

A disintegrin and metalloprotease-17 (ADAM17) is a major sheddase responsible for the regulation of a wide range of biological processes, like cellular differentiation, regeneration, or cancer progression. Hitherto, the mechanism regulating the enzymatic activity of ADAM17 is poorly ...

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05.04.2013 | Silu Zhang; Zhiqin Chu; Chun Yin; Chunyuan Zhang; Ge Lin; Quan Li, Journal of the American Chemical Society, 2013

Drug release simultaneously with carrier decomposition has been demonstrated in SiO2-drug composite nanoparticles. By creating a radial drug concentration gradient in the nanoparticle, controllable release of the drug is primarily driven by diffusion. Escape of the drug molecules then ...

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04.04.2013 | Kohei Kusada; Hirokazu Kobayashi; Tomokazu Yamamoto; Syo Matsumura; Naoya, Sumi; Katsutoshi Sato; Katsutoshi Nagaoka ..., Journal of the American Chemical Society, 2013

We report the first discovery of pure face-centered-cubic (fcc) Ru nanoparticles. Although the fcc structure does not exist in the bulk Ru phase diagram, fcc Ru was obtained at room temperature because of the nanosize effect. We succeeded in separately synthesizing uniformly sized ...

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04.04.2013 | William Edwards; David K. Smith, Journal of the American Chemical Society, 2013

We report a two-component acid–amine gelation system which forms instant organogels on simple mixing. We investigate self-assembly using a wide range of different amines and identify the optimum amines for gelation to occur. Using NMR and other spectroscopic methods, we unambiguously ...

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04.04.2013 | Ji-Hun Seo; Sachiro Kakinoki; Yuuki Inoue; Tetsuji Yamaoka; Kazuhiko Ishihara; Nobuhiko Yui, Journal of the American Chemical Society, 2013

Journal of the American Chemical Society DOI: 10.1021/ja400817q

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04.04.2013 | Trinanjana Mandal; Michael D. Ward, Journal of the American Chemical Society, 2013

The pathogenesis of l-cystine kidney stones involves four critical steps: nucleation, crystal growth, crystal aggregation, and crystal adhesion to cells. Although inhibition of crystal growth by l-cystine “imposters” at l-cystine crystal surfaces has been suggested as a plausible route for ...

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