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28.401 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Distinct gating mechanism of SOC channel involving STIM-Orai coupling and an intramolecular interaction of Orai in Caenorhabditis elegans [Cell Biology]

15.05.2018 | Kyu Min Kim; Tharaka Wijerathne; Jin-Hoe Hur; Uk Jung Kang; Ihn Hyeong Kim; Yeong Cheon Kweon; Ah Reum Lee; Su Ji Je ..., Proceedings of the National Academy of Sciences current issue, 2018

Store-operated calcium entry (SOCE) is a widespread, essential signaling mechanism for cellular functions in both invertebrates and vertebrates and is controlled by two membrane proteins, STIM in the endoplasmic reticulum (ER) and Orai, in the plasma membrane (PM). How these proteins residing in ...

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An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP [Biochemistry]

15.05.2018 | Mackenzie J. Parker; Ailiena O. Maggiolo; William C. Thomas; Albert Kim; Steve P. Meisburger; Nozomi Ando; Amie K. B ..., Proceedings of the National Academy of Sciences current issue, 2018

Negative feedback regulation of ribonucleotide reductase (RNR) activity by dATP is important for maintaining balanced intracellular 2ʹ-deoxynucleoside triphosphate (dNTP) pools essential for the high fidelity of DNA replication and repair. To date, this type of allostery has been nearly ...

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Genomic adaptation to drought in wild barley is driven by edaphic natural selection at the Tabigha Evolution Slope [Evolution]

15.05.2018 | Xiaolei Wang; Zhong-Hua Chen; Chongyi Yang; Xuelei Zhang; Gulei Jin; Guang Chen; Yuanyuan Wang; Paul Holford; Eviata ..., Proceedings of the National Academy of Sciences current issue, 2018

Microsite evolution involving ecological divergence due to geological, edaphic, or climatic conditions requires adaptive complexes to environmental stresses. The higher drought tolerance of wild barley populations inhabiting Terra Rossa soil at the Tabigha Evolution Slope has been described, but ...

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Earth’s magnetic field is probably not reversing [Earth, Atmospheric, and Planetary Sciences]

15.05.2018 | Maxwell Brown; Monika Korte; Richard Holme; Ingo Wardinski; Sydney Gunnarson, Proceedings of the National Academy of Sciences current issue, 2018

Earth’s magnetic field is generated in Earth’s convecting liquid iron outer core and protects Earth’s surface from harmful solar radiation. The field has varied on different timescales throughout geological history, and these variations reflect changes deep within the Earth. Two of the field’s ...

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Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress [Psychological and Cognitive Sciences]

15.05.2018 | Da Meng; Hui-quan Li; Karl Deisseroth; Stefan Leutgeb; Nicholas C. Spitzer, Proceedings of the National Academy of Sciences current issue, 2018

The discovery that neurotransmitter identity is regulated by activity in the adult mammalian brain during a stress response raises questions about the extent and function of this plasticity. Specific synapses are associated with the release of a particular neurotransmitter or transmitters on the ...

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Loss of a highly conserved sterile alpha motif domain gene (WEEP) results in pendulous branch growth in peach trees [Plant Biology]

15.05.2018 | Courtney A. Hollender; Thierry Pascal; Amy Tabb; Toto Hadiarto; Chinnathambi Srinivasan; Wanpeng Wang; Zhongchi Liu; ..., Proceedings of the National Academy of Sciences current issue, 2018

Trees’ branches grow against the pull of gravity and toward light. Although gravity and light perception have been studied in model species, much is unknown about how trees detect and respond to these signals. Here, we report the identification of a gene ( WEEP ) that controls lateral branch ...

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Jack Halpern (1925-2018): Pioneer of homogeneous catalysis [Retrospectives]

15.05.2018 | John E. Bercaw, Proceedings of the National Academy of Sciences current issue, 2018

Jack Halpern, a preeminent scholar and father of modern organometallic chemistry and homogeneous catalysis, died January 31, 2018 at the age of 93. Homogeneous catalysis by transition metal complexes, a field that has many important scientific and technological applications, can be traced to his ...

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Hidden collapse is driven by fire and logging in a socioecological forest ecosystem [Sustainability Science]

15.05.2018 | David B. Lindenmayer; Chloe Sato, Proceedings of the National Academy of Sciences current issue, 2018

Almost all descriptions of ecosystem collapse are made after it has occurred and not during the process of collapse. We describe the process of collapse in the iconic Australian Mountain Ash ecosystem. We uncovered empirical evidence for hidden collapse, which occurs when an ecosystem ...

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Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1 [Genetics]

15.05.2018 | Aaron Seo; Orna Steinberg-Shemer; Sule Unal; Silvia Casadei; Tom Walsh; Fatma Gumruk; Stavit Shalev; Akiko Shimamura ..., Proceedings of the National Academy of Sciences current issue, 2018

Many patients with breast and ovarian cancer carry inherited cancer-predisposing mutations in BRCA1 . However, virtually no patients have two inherited mutations in BRCA1 because the DNA repair function of BRCA1 is essential for embryonic development. We discovered that patients with two nonsense ...

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Revisiting the role of IRF3 in inflammation and immunity by conditional and specifically targeted gene ablation in mice [Immunology and Inflammation]

15.05.2018 | Hideyuki Yanai; Shiho Chiba; Sho Hangai; Kohei Kometani; Asuka Inoue; Yoshitaka Kimura; Takaya Abe; Hiroshi Kiyonari ..., Proceedings of the National Academy of Sciences current issue, 2018

IFN regulatory factor 3 (IRF3) is one of the most well-characterized transcription factors involved in the regulation of innate immune responses. Many studies have used conventional Irf3 -deficient mice to analyze the functions of IRF3 in immunity and other biological systems; however, these mice ...

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