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27.074 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis [Biochemistry]

05.09.2017 | Shuzhen Liu; Hua Liu; Andrea Johnston; Sarah Hanna-Addams; Eduardo Reynoso; Yougui Xiang; Zhigao Wang, Proceedings of the National Academy of Sciences current issue, 2017

Mixed-lineage kinase domain-like protein (MLKL) is essential for TNF-α–induced necroptosis. How MLKL promotes cell death is still under debate. Here we report that MLKL forms SDS-resistant, disulfide bond-dependent polymers during necroptosis in both human and mouse cells. MLKL polymers are ...

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Nasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis [Medical Sciences]

05.09.2017 | Liangru Ke; Hufeng Zhou; Chong Wang; Geng Xiong; Yanqun Xiang; Yihong Ling; Abdelmajid Khabir; George S. Tsao; Yixin ..., Proceedings of the National Academy of Sciences current issue, 2017

Nasopharyngeal carcinoma (NPC) most frequently occurs in southern China and southeast Asia. Epidemiology studies link NPC to genetic predisposition, Epstein–Barr virus (EBV) infection, and environmental factors. Genetic studies indicate that mutations in chromatin-modifying enzymes are the most ...

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Deep evolutionary conservation of autism-related genes [Evolution]

05.09.2017 | Hagai Y. Shpigler; Michael C. Saul; Frida Corona; Lindsey Block; Amy Cash Ahmed; Sihai D. Zhao; Gene E. Robinson, Proceedings of the National Academy of Sciences current issue, 2017

E. O. Wilson proposed in Sociobiology that similarities between human and animal societies reflect common mechanistic and evolutionary roots. When introduced in 1975, this controversial hypothesis was beyond science’s ability to test. We used genomic analyses to determine whether superficial ...

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On transient climate change at the Cretaceous-Paleogene boundary due to atmospheric soot inȷections [Earth, Atmospheric, and Planetary Sciences]

05.09.2017 | Charles G. Bardeen; Rolando R. Garcia; Owen B. Toon; Andrew J. Conley, Proceedings of the National Academy of Sciences current issue, 2017

Climate simulations that consider injection into the atmosphere of 15,000 Tg of soot, the amount estimated to be present at the Cretaceous−Paleogene boundary, produce what might have been one of the largest episodes of transient climate change in Earth history. The observed soot is believed to ...

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Vertebrate-like CRYPTOCHROME 2 from monarch regulates circadian transcription via independent repression of CLOCK and BMAL1 activity [Genetics]

05.09.2017 | Ying Zhang; Matthew J. Markert; Shayna C. Groves; Paul E. Hardin; Christine Merlin, Proceedings of the National Academy of Sciences current issue, 2017

Circadian repression of CLOCK-BMAL1 by PERIOD and CRYPTOCHROME (CRY) in mammals lies at the core of the circadian timekeeping mechanism. CRY repression of CLOCK-BMAL1 and regulation of circadian period are proposed to rely primarily on competition for binding with coactivators on an α-helix ...

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Molecularly targeted drug combinations demonstrate selective effectiveness for myeloid- and lymphoid-derived hematologic malignancies [Medical Sciences]

05.09.2017 | Stephen E. Kurtz; Christopher A. Eide; Andy Kaempf; Vishesh Khanna; Samantha L. Savage; Angela Rofelty; Isabel Engli ..., Proceedings of the National Academy of Sciences current issue, 2017

Translating the genetic and epigenetic heterogeneity underlying human cancers into therapeutic strategies is an ongoing challenge. Large-scale sequencing efforts have uncovered a spectrum of mutations in many hematologic malignancies, including acute myeloid leukemia (AML), suggesting that ...

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Hydrodynamic and entropic effects on colloidal diffusion in corrugated channels [Physics]

05.09.2017 | Xiang Yang; Chang Liu; Yunyun Li; Fabio Marchesoni; Peter Hänggi; H. P. Zhang, Proceedings of the National Academy of Sciences current issue, 2017

In the absence of advection, confined diffusion characterizes transport in many natural and artificial devices, such as ionic channels, zeolites, and nanopores. While extensive theoretical and numerical studies on this subject have produced many important predictions, experimental verifications ...

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Exposure to rising inequality shapes Americans’ opportunity beliefs and policy support [Social Sciences]

05.09.2017 | Leslie McCall; Derek Burk; Marie Laperrière; Jennifer A. Richeson, Proceedings of the National Academy of Sciences current issue, 2017

Economic inequality has been on the rise in the United States since the 1980s and by some measures stands at levels not seen since before the Great Depression. Although the strikingly high and rising level of economic inequality in the nation has alarmed scholars, pundits, and elected officials ...

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Indoles from commensal bacteria extend healthspan [Genetics]

05.09.2017 | Robert Sonowal; Alyson Swimm; Anusmita Sahoo; Liping Luo; Yohei Matsunaga; Ziqi Wu; Jui A. Bhingarde; Elizabeth A. E ..., Proceedings of the National Academy of Sciences current issue, 2017

Multiple studies have identified conserved genetic pathways and small molecules associated with extension of lifespan in diverse organisms. However, extending lifespan does not result in concomitant extension in healthspan, defined as the proportion of time that an animal remains healthy and free ...

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Motile cilia create fluid-mechanical microhabitats for the active recruitment of the host microbiome [Biophysics and Computational Biology]

05.09.2017 | Janna C. Nawroth; Hanliang Guo; Eric Koch; Elizabeth A. C. Heath-Heckman; John C. Hermanson; Edward G. Ruby; John O. ..., Proceedings of the National Academy of Sciences current issue, 2017

We show that mucociliary membranes of animal epithelia can create fluid-mechanical microenvironments for the active recruitment of the specific microbiome of the host. In terrestrial vertebrates, these tissues are typically colonized by complex consortia and are inaccessible to observation. Such ...

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