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26.772 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Optimal decision making and matching are tied through diminishing returns [Psychological and Cognitive Sciences]

08.08.2017 | Jan Kubanek, Proceedings of the National Academy of Sciences current issue, 2017

How individuals make decisions has been a matter of long-standing debate among economists and researchers in the life sciences. In economics, subjects are viewed as optimal decision makers who maximize their overall reward income. This framework has been widely influential, but requires a ...

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Deacetylase activity of histone deacetylase 3 is required for productive VDJ recombination and B-cell development [Genetics]

08.08.2017 | Kristy R. Stengel; Kelly R. Barnett; Jing Wang; Qi Liu; Emily Hodges; Scott W. Hiebert; Srividya Bhaskara, Proceedings of the National Academy of Sciences current issue, 2017

Histone deacetylase 3 (HDAC3) is the catalytic component of NCoR/SMRT corepressor complexes that mediate the actions of transcription factors implicated in the regulation of B-cell development and function. We crossed Hdac3 conditional knockout mice with Mb1-Cre knockin animals to delete Hdac3 in ...

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Effective intermediate-spin iron in O2-transporting heme proteins [Biophysics and Computational Biology]

08.08.2017 | Nils Schuth; Stefan Mebs; Dennis Huwald; Pierre Wrzolek; Matthias Schwalbe; Anja Hemschemeier; Michael Haumann, Proceedings of the National Academy of Sciences current issue, 2017

Proteins carrying an iron-porphyrin (heme) cofactor are essential for biological O2 management. The nature of Fe-O2 bonding in hemoproteins is debated for decades. We used energy-sampling and rapid-scan X-ray Kβ emission and K-edge absorption spectroscopy as well as quantum chemistry to determine ...

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Unique structural features of the AIPL1-FKBP domain that support prenyl lipid binding and underlie protein malfunction in blindness [Biochemistry]

08.08.2017 | Ravi P. Yadav; Lokesh Gakhar; Liping Yu; Nikolai O. Artemyev, Proceedings of the National Academy of Sciences current issue, 2017

FKBP-domain proteins (FKBPs) are pivotal modulators of cellular signaling, protein folding, and gene transcription. Aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) is a distinctive member of the FKBP superfamily in terms of its biochemical properties, and it plays an important ...

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Rho-associated kinase is a therapeutic target in neuroblastoma [Medical Sciences]

08.08.2017 | Cecilia Dyberg; Susanne Fransson; Teodora Andonova; Baldur Sveinbjörnsson; Jessika Lännerholm-Palm; Thale K. Olsen; ..., Proceedings of the National Academy of Sciences current issue, 2017

Neuroblastoma is a peripheral neural system tumor that originates from the neural crest and is the most common and deadly tumor of infancy. Here we show that neuroblastoma harbors frequent mutations of genes controlling the Rac/Rho signaling cascade important for proper migration and ...

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Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection [Medical Sciences]

08.08.2017 | Nikolaos M. Nikolaidis; John G. Noel; Lori B. Pitstick; Jason C. Gardner; Yasuaki Uehara; Huixing Wu; Atsushi Saito; ..., Proceedings of the National Academy of Sciences current issue, 2017

Development of pneumonia is the most lethal consequence of influenza, increasing mortality more than 50-fold compared with uncomplicated infection. The spread of viral infection from conducting airways to the alveolar epithelium is therefore a pivotal event in influenza pathogenesis. We found ...

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Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling [Biophysics and Computational Biology]

08.08.2017 | Mark M. Hughes; Peter Lavrencic; Rebecca C. Coll; Thomas Ve; Dylan G. Ryan; Niamh C. Williams; Deepthi Menon; Ashley ..., Proceedings of the National Academy of Sciences current issue, 2017

MyD88 adaptor-like (MAL) is a critical protein in innate immunity, involved in signaling by several Toll-like receptors (TLRs), key pattern recognition receptors (PRRs). Crystal structures of MAL revealed a nontypical Toll/interleukin-1 receptor (TIR)-domain fold stabilized by two disulfide ...

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Stem parasitic plant Cuscuta australis (dodder) transfers herbivory-induced signals among plants [Plant Biology]

08.08.2017 | Christian Hettenhausen; Juan Li; Huifu Zhuang; Huanhuan Sun; Yuxing Xu; Jinfeng Qi; Jingxiong Zhang; Yunting Lei; Ya ..., Proceedings of the National Academy of Sciences current issue, 2017

Cuscuta spp. (i.e., dodders) are stem parasites that naturally graft to their host plants to extract water and nutrients; multiple adjacent hosts are often parasitized by one or more Cuscuta plants simultaneously, forming connected plant clusters. Metabolites, proteins, and mRNAs are known to be ...

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Rainforest metropolis casts 1,000-km defaunation shadow [Sustainability Science]

08.08.2017 | Daniel J. Tregidgo; Jos Barlow; Paulo S. Pompeu; Mayana de Almeida Rocha; Luke Parry, Proceedings of the National Academy of Sciences current issue, 2017

Tropical rainforest regions are urbanizing rapidly, yet the role of emerging metropolises in driving wildlife overharvesting in forests and inland waters is unknown. We present evidence of a large defaunation shadow around a rainforest metropolis. Using interviews with 392 rural fishers, we show ...

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Activin signaling mediates muscle-to-adipose communication in a mitochondria dysfunction-associated obesity model [Genetics]

08.08.2017 | Wei Song; Edward Owusu-Ansah; Yanhui Hu; Daojun Cheng; Xiaochun Ni; Jonathan Zirin; Norbert Perrimon, Proceedings of the National Academy of Sciences current issue, 2017

Mitochondrial dysfunction has been associated with obesity and metabolic disorders. However, whether mitochondrial perturbation in a single tissue influences mitochondrial function and metabolic status of another distal tissue remains largely unknown. We analyzed the nonautonomous role of ...

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