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24.097 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Control of Hoxd gene transcription in the mammary bud by hijacking a preexisting regulatory landscape [Developmental Biology]

29.11.2016 | Ruben Schep; Anamaria Necsulea; Eddie Rodríguez-Carballo; Isabel Guerreiro; Guillaume Andrey; Thi Hanh Nguyen Huynh; ..., Proceedings of the National Academy of Sciences current issue, 2016

Vertebrate Hox genes encode transcription factors operating during the development of multiple organs and structures. However, the evolutionary mechanism underlying this remarkable pleiotropy remains to be fully understood. Here, we show that Hoxd8 and Hoxd9, two genes of the HoxD complex, are ...

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Ligand-induced and small-molecule control of substrate loading in a hexameric helicase [Biochemistry]

29.11.2016 | Michael R. Lawson; Kevin Dyer; James M. Berger, Proceedings of the National Academy of Sciences current issue, 2016

Processive, ring-shaped protein and nucleic acid protein translocases control essential biochemical processes throughout biology and are considered high-prospect therapeutic targets. The Escherichia coli Rho factor is an exemplar hexameric RNA translocase that terminates transcription in ...

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DNA polymerase {zeta} limits chromosomal damage and promotes cell survival following aflatoxin exposure [Cell Biology]

29.11.2016 | Ying-Chih Lin; Nichole Owen; Irina G. Minko; Sabine S. Lange; Liang Li; Michael P. Stone; Richard D. Wood; Amanda K. ..., Proceedings of the National Academy of Sciences current issue, 2016

Routine dietary consumption of foods that contain aflatoxins is the second leading cause of environmental carcinogenesis worldwide. Aflatoxin-driven mutagenesis is initiated through metabolic activation of aflatoxin B1 (AFB1) to its epoxide form that reacts with N7 guanine in DNA. The resulting ...

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Multistep crystallization processes: How not to make perfect single crystals [Chemistry]

29.11.2016 | Daniel Bonn; Noushine Shahidzadeh, Proceedings of the National Academy of Sciences current issue, 2016

The beauty of snowflakes originates from the very different ways the ice crystals grow in different environments (1, 2). The amazing variety of snowflake crystal shapes occurs despite the fact that the crystalline structure of snow is always the same: the thermodynamic equilibrium shape is a ...

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Correction for Sakata et al., Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid [Correction]

29.11.2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Voltage-dependent motion of the catalytic region of voltage-sensing phosphatase monitored by a fluorescent amino acid,” by Souhei Sakata, Yuka Jinno, Akira Kawanabe, and Yasushi Okamura, which appeared in issue 27, July 5, 2016, of Proc Natl ...

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Armed conflict and population displacement as drivers of the evolution and dispersal of Mycobacterium tuberculosis [Microbiology]

29.11.2016 | Vegard Eldholm; John H.-O. Pettersson; Ola B. Brynildsrud; Andrew Kitchen; Erik Michael Rasmussen; Troels Lillebaek; ..., Proceedings of the National Academy of Sciences current issue, 2016

The “Beijing” Mycobacterium tuberculosis (Mtb) lineage 2 (L2) is spreading globally and has been associated with accelerated disease progression and increased antibiotic resistance. Here we performed a phylodynamic reconstruction of one of the L2 sublineages, the central Asian clade (CAC), which ...

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Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma [Immunology and Inflammation]

29.11.2016 | Stefani Spranger; Jason J. Luke; Riyue Bao; Yuanyuan Zha; Kyle M. Hernandez; Yan Li; Alexander P. Gajewski; Jorge An ..., Proceedings of the National Academy of Sciences current issue, 2016

Melanoma metastases can be categorized by gene expression for the presence of a T-cell–inflamed tumor microenvironment, which correlates with clinical efficacy of immunotherapies. T cells frequently recognize mutational antigens corresponding to nonsynonymous somatic mutations (NSSMs), and in ...

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Fermi liquid behavior of the in-plane resistivity in the pseudogap state of YBa2Cu4O8 [Physics]

29.11.2016 | Cyril Proust; Baptiste Vignolle; Julien Levallois; S. Adachi; Nigel E. Hussey, Proceedings of the National Academy of Sciences current issue, 2016

Our knowledge of the ground state of underdoped hole-doped cuprates has evolved considerably over the last few years. There is now compelling evidence that, inside the pseudogap phase, charge order breaks translational symmetry leading to a reconstructed Fermi surface made of small pockets. ...

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In This Issue [This Week in PNAS]

29.11.2016 | Proceedings of the National Academy of Sciences current issue, 2016

Tuberculosis evolution and armed conflict M. tuberculosis. Image courtesy of Flickr/National Institute of Allergy and Infectious Diseases. Lineage 2 (L2) of Mycobacterium tuberculosis is spreading globally and has been associated with accelerated disease progression and increased drug resistance. ...

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Identification and characterization of high methane-emitting abandoned oil and gas wells [Sustainability Science]

29.11.2016 | Mary Kang; Shanna Christian; Michael A. Celia; Denise L. Mauzerall; Markus Bill; Alana R. Miller; Yuheng Chen; Mark ..., Proceedings of the National Academy of Sciences current issue, 2016

Recent measurements of methane emissions from abandoned oil/gas wells show that these wells can be a substantial source of methane to the atmosphere, particularly from a small proportion of high-emitting wells. However, identifying high emitters remains a challenge. We couple 163 well ...

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