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24.862 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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A pathway of targeted autophagy is induced by DNA damage in budding yeast [Genetics]

14.02.2017 | Vinay V. Eapen; David P. Waterman; Amélie Bernard; Nathan Schiffmann; Enrich Sayas; Roarke Kamber; Brenda Lemos; Gon ..., Proceedings of the National Academy of Sciences current issue, 2017

Autophagy plays a central role in the DNA damage response (DDR) by controlling the levels of various DNA repair and checkpoint proteins; however, how the DDR communicates with the autophagy pathway remains unknown. Using budding yeast, we demonstrate that global genotoxic damage or even a single ...

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Harnessing host ROS-generating machinery for the robust genome replication of a plant RNA virus [Plant Biology]

14.02.2017 | Kiwamu Hyodo; Kenji Hashimoto; Kazuyuki Kuchitsu; Nobuhiro Suzuki; Tetsuro Okuno, Proceedings of the National Academy of Sciences current issue, 2017

As sessile organisms, plants have to accommodate to rapid changes in their surrounding environment. Reactive oxygen species (ROS) act as signaling molecules to transduce biotic and abiotic stimuli into plant stress adaptations. It is established that a respiratory burst oxidase homolog B of ...

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Single-residue molecular switch for high-temperature dependence of vanilloid receptor TRPV3 [Biophysics and Computational Biology]

14.02.2017 | Beiying Liu; Feng Qin, Proceedings of the National Academy of Sciences current issue, 2017

Thermal transient receptor potential (TRP) channels, a group of ion channels from the transient receptor potential family, play important functions in pain and thermal sensation. These channels are directly activated by temperature and possess strong temperature dependence. Furthermore, their ...

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pKa of Glu325 in LacY [Biophysics and Computational Biology]

14.02.2017 | Natalia Grytsyk; Junichi Sugihara; H. Ronald Kaback; Petra Hellwig, Proceedings of the National Academy of Sciences current issue, 2017

Lactose permease (LacY), a paradigm for the largest family of membrane transport proteins, catalyzes the coupled translocation of a galactoside and a H+ across the cytoplasmic membrane of Escherichia coli (galactoside/H+ symport). One of the most important aspects of the mechanism is the ...

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IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice [Immunology and Inflammation]

14.02.2017 | Jin Huk Choi; Kuan-wen Wang; Duanwu Zhang; Xiaowei Zhan; Tao Wang; Chun-Hui Bu; Cassie L. Behrendt; Ming Zeng; Ying ..., Proceedings of the National Academy of Sciences current issue, 2017

Class-switch recombination (CSR) alters the Ig isotype to diversify antibody effector functions. IgD CSR is a rare event, and its regulation is poorly understood. We report that deficiency of 53BP1, a DNA damage-response protein, caused age-dependent overproduction of secreted IgD resulting from ...

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Dehydrogenation of goethite in Earth’s deep lower mantle [Earth, Atmospheric, and Planetary Sciences]

14.02.2017 | Qingyang Hu; Duck Young Kim; Jin Liu; Yue Meng; Liuxiang Yang; Dongzhou Zhang; Wendy L. Mao; Ho-kwang Mao, Proceedings of the National Academy of Sciences current issue, 2017

The cycling of hydrogen influences the structure, composition, and stratification of Earth’s interior. Our recent discovery of pyrite-structured iron peroxide (designated as the P phase) and the formation of the P phase from dehydrogenation of goethite FeO2H implies the separation of the oxygen ...

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Influence of iron doping on tetravalent nickel content in catalytic oxygen evolving films [Chemistry]

14.02.2017 | Nancy Li; D. Kwabena Bediako; Ryan G. Hadt; Dugan Hayes; Thomas J. Kempa; Felix von Cube; David C. Bell; Lin X. Chen ..., Proceedings of the National Academy of Sciences current issue, 2017

Iron doping of nickel oxide films results in enhanced activity for promoting the oxygen evolution reaction (OER). Whereas this enhanced activity has been ascribed to a unique iron site within the nickel oxide matrix, we show here that Fe doping influences the Ni valency. The percent of Fe3+ ...

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Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction [Physiology]

14.02.2017 | Santosh Kumar; Young-Rae Kim; Ajit Vikram; Asma Naqvi; Qiuxia Li; Modar Kassan; Vikas Kumar; Markus M. Bachschmid; J ..., Proceedings of the National Academy of Sciences current issue, 2017

The 66-kDa Src homology 2 domain-containing protein (p66Shc) is a master regulator of reactive oxygen species (ROS). It is expressed in many tissues where it contributes to organ dysfunction by promoting oxidative stress. In the vasculature, p66Shc-induced ROS engenders endothelial dysfunction. ...

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Trifunctional lipid probes for comprehensive studies of single lipid species in living cells [Biochemistry]

14.02.2017 | Doris Höglinger; André Nadler; Per Haberkant; Joanna Kirkpatrick; Martina Schifferer; Frank Stein; Sebastian Hauke; ..., Proceedings of the National Academy of Sciences current issue, 2017

Lipid-mediated signaling events regulate many cellular processes. Investigations of the complex underlying mechanisms are difficult because several different methods need to be used under varying conditions. Here we introduce multifunctional lipid derivatives to study lipid metabolism, ...

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Reply to Johnson et al.: Functionally active cryptophyte cell membrane and cytoplasm indicate intact symbionts within Mesodinium [Biological Sciences]

14.02.2017 | Dajun Qiu; Lingxiao Lin; Senjie Lin, Proceedings of the National Academy of Sciences current issue, 2017

We would like to thank Johnson et al. (1) for their interest in our paper. They contest our view (2) that simultaneous expression of cell membrane, organellar, and cytoplasmic protein genes of Teleaulax amphioxeia in Mesodinium rubrum indicate a complete endosymbiont. First, Johnson et al. ...

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