Meine Merkliste
my.chemie.de  
Login  

22.033 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

rss

Sie können Ihre Recherche weiter verfeinern. Wählen Sie aus dem linken Bereich passende Suchfilter aus, um Ihre Ergebnisse gezielt einzugrenzen.

Ion channels find a pathway for therapeutic success [Pharmacology]

17.05.2016 | Maria L. Garcia; Gregory J. Kaczorowski, Proceedings of the National Academy of Sciences current issue, 2016

Drug discovery and development are complex processes that require long-term commitments to bring such efforts to fruition. Traditionally, there is low probability of success in being able to take new pharmacological agents all of the way through regulatory approval for use in man. There are ...

mehr

Intercellular signaling through secreted proteins induces free-energy gradient-directed cell movement [Biophysics and Computational Biology]

17.05.2016 | Nataly Kravchenko-Balasha; Young Shik Shin; Alex Sutherland; R. D. Levine; James R. Heath, Proceedings of the National Academy of Sciences current issue, 2016

Controlling cell migration is important in tissue engineering and medicine. Cell motility depends on factors such as nutrient concentration gradients and soluble factor signaling. In particular, cell–cell signaling can depend on cell–cell separation distance and can influence cellular ...

mehr

Cortical thickness of the dorsolateral prefrontal cortex predicts strategic choices in economic games [Psychological and Cognitive Sciences]

17.05.2016 | Toshio Yamagishi; Haruto Takagishi; Alan de Souza Rodrigues Fermin; Ryota Kanai; Yang Li; Yoshie Matsumoto, Proceedings of the National Academy of Sciences current issue, 2016

Human prosociality has been traditionally explained in the social sciences in terms of internalized social norms. Recent neuroscientific studies extended this traditional view of human prosociality by providing evidence that prosocial choices in economic games require cognitive control of the ...

mehr

Control of active liquid crystals with a magnetic field [Applied Physical Sciences]

17.05.2016 | Pau Guillamat; Jordi Ignés-Mullol; Francesc Sagués, Proceedings of the National Academy of Sciences current issue, 2016

Living cells sense the mechanical features of their environment and adapt to it by actively remodeling their peripheral network of filamentary proteins, known as cortical cytoskeleton. By mimicking this principle, we demonstrate an effective control strategy for a microtubule-based active nematic ...

mehr

TPC2 controls pigmentation by regulating melanosome pH and size [Cell Biology]

17.05.2016 | Andrea L. Ambrosio; Judith A. Boyle; Al E. Aradi; Keith A. Christian; Santiago M. Di Pietro, Proceedings of the National Academy of Sciences current issue, 2016

Melanin is responsible for pigmentation of skin and hair and is synthesized in a specialized organelle, the melanosome, in melanocytes. A genome-wide association study revealed that the two pore segment channel 2 (TPCN2) gene is strongly linked to pigmentation variations. TPCN2 encodes the ...

mehr

Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion [Biochemistry]

17.05.2016 | Benoît Desguin; Patrice Soumillion; Pascal Hols; Robert P. Hausinger, Proceedings of the National Academy of Sciences current issue, 2016

The lactate racemase enzyme (LarA) of Lactobacillus plantarum harbors a (SCS)Ni(II) pincer complex derived from nicotinic acid. Synthesis of the enzyme-bound cofactor requires LarB, LarC, and LarE, which are widely distributed in microorganisms. The functions of the accessory proteins are ...

mehr

Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels [Applied Physical Sciences]

17.05.2016 | Sungmin Nam; Kenneth H. Hu; Manish J. Butte; Ovijit Chaudhuri, Proceedings of the National Academy of Sciences current issue, 2016

The extracellular matrix (ECM) is a complex assembly of structural proteins that provides physical support and biochemical signaling to cells in tissues. The mechanical properties of the ECM have been found to play a key role in regulating cell behaviors such as differentiation and malignancy. ...

mehr

Predicting the evolutionary dynamics of seasonal adaptation to novel climates in Arabidopsis thaliana [Evolution]

17.05.2016 | Alexandre Fournier-Level; Emily O. Perry; Jonathan A. Wang; Peter T. Braun; Andrew Migneault; Martha D. Cooper; C. J ..., Proceedings of the National Academy of Sciences current issue, 2016

Predicting whether and how populations will adapt to rapid climate change is a critical goal for evolutionary biology. To examine the genetic basis of fitness and predict adaptive evolution in novel climates with seasonal variation, we grew a diverse panel of the annual plant Arabidopsis thaliana ...

mehr

News Feature: Better models for brain disease [Psychological and Cognitive Sciences]

17.05.2016 | Helen H. Shen, Proceedings of the National Academy of Sciences current issue, 2016

Traditional animal models have had limited success mimicking mental illnesses. Emerging technologies offer the potential for a major model upgrade. Starting with just a tiny chunk of skin, neuroscientist Flora Vaccarino tries to unlock mysteries hidden inside the brains of people with autism. By ...

mehr

PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndrome [Physiology]

17.05.2016 | Hong Chen; Abul Fajol; Miriam Hoene; Bingbing Zhang; Erwin D. Schleicher; Yun Lin; Carsten Calaminus; Bernd J. Pichl ..., Proceedings of the National Academy of Sciences current issue, 2016

Metabolic syndrome is characterized by insulin resistance, obesity, and dyslipidemia. It is the consequence of an imbalance between caloric intake and energy consumption. Adiponectin protects against metabolic syndrome. Insulin-induced signaling includes activation of PI3 kinase and protein ...

mehr

Seite 1 von 2204
Suche per e-Mail abonnieren

Sie erhalten passend zu Ihrer Suche die neusten Suchergebnisse per E-Mail. Dieser Service ist für Sie kostenlos und kann jederzeit abbestellt werden.

Ihr Bowser ist nicht aktuell. Microsoft Internet Explorer 6.0 unterstützt einige Funktionen auf Chemie.DE nicht.