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25.191 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Human-started wildfires expand the fire niche across the United States [Sustainability Science]

14.03.2017 | Jennifer K. Balch; Bethany A. Bradley; John T. Abatzoglou; R. Chelsea Nagy; Emily J. Fusco; Adam L. Mahood, Proceedings of the National Academy of Sciences current issue, 2017

The economic and ecological costs of wildfire in the United States have risen substantially in recent decades. Although climate change has likely enabled a portion of the increase in wildfire activity, the direct role of people in increasing wildfire activity has been largely overlooked. We ...

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Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors [Neuroscience]

14.03.2017 | Marc Ehrlich; Sabah Mozafari; Michael Glatza; Laura Starost; Sergiy Velychko; Anna-Lena Hallmann; Qiao-Ling Cui; Axe ..., Proceedings of the National Academy of Sciences current issue, 2017

Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to understand the biology of myelin diseases and to develop treatments for such disorders. Here, we demonstrate that the induction of ...

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Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules [Medical Sciences]

14.03.2017 | Marlon G. Lawrence; Michael K. Altenburg; Ryan Sanford; Julian D. Willett; Benjamin Bleasdale; Byron Ballou; Jennife ..., Proceedings of the National Academy of Sciences current issue, 2017

How the kidney prevents urinary excretion of plasma proteins continues to be debated. Here, using unfixed whole-mount mouse kidneys, we show that fluorescent-tagged proteins and neutral dextrans permeate into the glomerular basement membrane (GBM), in general agreement with Ogston's 1958 equation ...

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Knowledge-based entropies improve the identification of native protein structures [Biophysics and Computational Biology]

14.03.2017 | Kannan Sankar; Kejue Jia; Robert L. Jernigan, Proceedings of the National Academy of Sciences current issue, 2017

Evaluating protein structures requires reliable free energies with good estimates of both potential energies and entropies. Although there are many demonstrated successes from using knowledge-based potential energies, computing entropies of proteins has lagged far behind. Here we take an entirely ...

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Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations [Biochemistry]

14.03.2017 | Yazan M. Abbas; Beatrice Theres Laudenbach; Saúl Martínez-Montero; Regina Cencic; Matthias Habjan; Andreas Pichlmair ..., Proceedings of the National Academy of Sciences current issue, 2017

IFIT1 (IFN-induced protein with tetratricopeptide repeats-1) is an effector of the host innate immune antiviral response that prevents propagation of virus infection by selectively inhibiting translation of viral mRNA. It relies on its ability to compete with the translation initiation factor ...

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Understanding band gaps of solids in generalized Kohn-Sham theory [Applied Physical Sciences]

14.03.2017 | John P. Perdew; Weitao Yang; Kieron Burke; Zenghui Yang; Eberhard K. U. Gross; Matthias Scheffler; Gustavo E. Scuser ..., Proceedings of the National Academy of Sciences current issue, 2017

The fundamental energy gap of a periodic solid distinguishes insulators from metals and characterizes low-energy single-electron excitations. However, the gap in the band structure of the exact multiplicative Kohn–Sham (KS) potential substantially underestimates the fundamental gap, a major ...

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Metabolic origins of spatial organization in the tumor microenvironment [Cell Biology]

14.03.2017 | Carlos Carmona-Fontaine; Maxime Deforet; Leila Akkari; Craig B. Thompson; Johanna A. Joyce; Joao B. Xavier, Proceedings of the National Academy of Sciences current issue, 2017

The genetic and phenotypic diversity of cells within tumors is a major obstacle for cancer treatment. Because of the stochastic nature of genetic alterations, this intratumoral heterogeneity is often viewed as chaotic. Here we show that the altered metabolism of cancer cells creates predictable ...

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Correction for Tung et al., {beta}-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model [Correction]

14.03.2017 | Proceedings of the National Academy of Sciences current issue, 2017

CELL BIOLOGY Correction for “β-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model,” by Bui Tung, Babette Schade, Robert D. Cardiff, Olulanu H. Aina, Virginie Sanguin-Gendreau, and William J. Muller, which appeared in issue 5, January 31, 2017, ...

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Emergence of communities and diversity in social networks [Applied Physical Sciences]

14.03.2017 | Xiao Han; Shinan Cao; Zhesi Shen; Boyu Zhang; Wen-Xu Wang; Ross Cressman; H. Eugene Stanley, Proceedings of the National Academy of Sciences current issue, 2017

Communities are common in complex networks and play a significant role in the functioning of social, biological, economic, and technological systems. Despite widespread interest in detecting community structures in complex networks and exploring the effect of communities on collective dynamics, a ...

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Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis [Medical Sciences]

14.03.2017 | Yiwen Zhang; Jian Zhang; Rong Yan; Jingluan Tian; Yang Zhang; Jie Zhang; Mengxing Chen; Qingya Cui; Lili Zhao; Renpi ..., Proceedings of the National Academy of Sciences current issue, 2017

Previous studies have shown that receptor-interacting protein kinase 3 (RIP3) is involved in many important biological processes, including necroptosis, apoptosis, and inflammation. Here we show that RIP3 plays a critical role in regulating platelet functions and in vivo thrombosis and ...

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