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22.972 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Pacemaker-neuron-dependent disturbance of the molecular clockwork by a Drosophila CLOCK mutant homologous to the mouse Clock mutation [Neuroscience]

16.08.2016 | Euna Lee; Eunjoo Cho; Doo Hyun Kang; Eun Hee Jeong; Zheng Chen; Seung-Hee Yoo; Eun Young Kim, Proceedings of the National Academy of Sciences current issue, 2016

Circadian clocks are composed of transcriptional/translational feedback loops (TTFLs) at the cellular level. In Drosophila TTFLs, the transcription factor dCLOCK (dCLK)/CYCLE (CYC) activates clock target gene expression, which is repressed by the physical interaction with PERIOD (PER). Here, we ...

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Stabilin-1 expression defines a subset of macrophages that mediate tissue homeostasis and prevent fibrosis in chronic liver injury [Cell Biology]

16.08.2016 | Pia Rantakari; Daniel A. Patten; Joona Valtonen; Marika Karikoski; Heidi Gerke; Harriet Dawes; Juha Laurila; Steffen ..., Proceedings of the National Academy of Sciences current issue, 2016

Macrophages are key regulators of fibrosis development and resolution. Elucidating the mechanisms by which they mediate this process is crucial for establishing their therapeutic potential. Here, we use experimental models of liver fibrosis to show that deficiency of the scavenger receptor, ...

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Wavy membranes and the growth rate of a planar chemical garden: Enhanced diffusion and bioenergetics [Applied Physical Sciences]

16.08.2016 | Yang Ding; Bruno Batista; Oliver Steinbock; Julyan H. E. Cartwright; Silvana S. S. Cardoso, Proceedings of the National Academy of Sciences current issue, 2016

To model ion transport across protocell membranes in Hadean hydrothermal vents, we consider both theoretically and experimentally the planar growth of a precipitate membrane formed at the interface between two parallel fluid streams in a 2D microfluidic reactor. The growth rate of the precipitate ...

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Dynamic periplasmic chaperone reservoir facilitates biogenesis of outer membrane proteins [Biophysics and Computational Biology]

16.08.2016 | Shawn M. Costello; Ashlee M. Plummer; Patrick J. Fleming; Karen G. Fleming, Proceedings of the National Academy of Sciences current issue, 2016

Outer membrane protein (OMP) biogenesis is critical to bacterial physiology because the cellular envelope is vital to bacterial pathogenesis and antibiotic resistance. The process of OMP biogenesis has been studied in vivo, and each of its components has been studied in isolation in vitro. This ...

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Eosinophils, galectins, and a reason to breathe [Immunology and Inflammation]

16.08.2016 | Helene F. Rosenberg; Kirk M. Druey, Proceedings of the National Academy of Sciences current issue, 2016

Asthma is a common and incurable inflammatory respiratory disease leading to wheezing, shortness of breath, and cough, that affects nearly 300 million people worldwide (1). Although the precise molecular cause of asthma remains unknown, diverse risk factors including environmental allergies, ...

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The need to overcome risks associated with combining inadequate paleozoological records and conservation biology [Social Sciences]

16.08.2016 | Michael Carrington Westaway; R. Lee Lyman, Proceedings of the National Academy of Sciences current issue, 2016

A key issue raised by Boivin et al. is that increased use of environmental archaeological data holds significant benefits for conservation planning (1). The benefits of the application of paleozoological records to conserving biodiversity have been emphasized by many (2), but there are also ...

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Distinct oxytocin effects on belief updating in response to desirable and undesirable feedback [Psychological and Cognitive Sciences]

16.08.2016 | Yina Ma; Shiyi Li; Chenbo Wang; Yi Liu; Wenxin Li; Xinyuan Yan; Qiang Chen; Shihui Han, Proceedings of the National Academy of Sciences current issue, 2016

Humans update their beliefs upon feedback and, accordingly, modify their behaviors to adapt to the complex, changing social environment. However, people tend to incorporate desirable (better than expected) feedback into their beliefs but to discount undesirable (worse than expected) feedback. ...

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Correction for Garcia-Ruiz et al., Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection [Correction]

16.08.2016 | Proceedings of the National Academy of Sciences current issue, 2016

AGRICULTURAL SCIENCES Correction for “Changes in genetic selection differentials and generation intervals in US Holstein dairy cattle as a result of genomic selection,” by Adriana García-Ruiz, John B. Cole, Paul M. VanRaden, George R. Wiggans, Felipe J. Ruiz-López, and Curtis P. Van Tassell, ...

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QnAs with James Allison [QnAs]

16.08.2016 | Prashant Nair, Proceedings of the National Academy of Sciences current issue, 2016

In May 2016, the United States Food and Drug Administration (FDA) approved atezolizumab for treating advanced bladder cancer. The drug, which marshals the immune system against cancer, is only the fourth in a class of drugs called checkpoint blockers to be approved by the FDA. By now a familiar ...

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Reply to Davis-Stober et al.: Violations of rationality in a psychophysical task are not aggregation artifacts [Biological Sciences]

16.08.2016 | Konstantinos Tsetsos; Rani Moran; James C. Moreland; Nick Chater; Marius Usher; Christopher Summerfield, Proceedings of the National Academy of Sciences current issue, 2016

Humans deviate from rational choice theory if their estimates of the attribute values for one alternative change as a function of the attribute values of competing alternatives (1). In our paper (2), we report such “context-dependent” (CD) deviations from rationality in the form of a frequent ...

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