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21.877 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Vitamin A-aldehyde adducts: AMD risk and targeted therapeutics [Medical Sciences]

26.04.2016 | Janet R. Sparrow, Proceedings of the National Academy of Sciences current issue, 2016

Although currently available treatment options for age-related macular degeneration (AMD) are limited, particularly for atrophic AMD, the identification of predisposing genetic variations has informed clinical studies addressing therapeutic options such as complement inhibitors and ...

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Cooperative folding near the downhill limit determined with amino acid resolution by hydrogen exchange [Biophysics and Computational Biology]

26.04.2016 | Wookyung Yu; Michael C. Baxa; Isabelle Gagnon; Karl F. Freed; Tobin R. Sosnick, Proceedings of the National Academy of Sciences current issue, 2016

The relationship between folding cooperativity and downhill, or barrier-free, folding of proteins under highly stabilizing conditions remains an unresolved topic, especially for proteins such as λ-repressor that fold on the microsecond timescale. Under aqueous conditions where downhill folding is ...

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Echolocating bats use future-target information for optimal foraging [Neuroscience]

26.04.2016 | Emyo Fujioka; Ikkyu Aihara; Miwa Sumiya; Kazuyuki Aihara; Shizuko Hiryu, Proceedings of the National Academy of Sciences current issue, 2016

When seeing or listening to an object, we aim our attention toward it. While capturing prey, many animal species focus their visual or acoustic attention toward the prey. However, for multiple prey items, the direction and timing of attention for effective foraging remain unknown. In this study, ...

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Correction for Lee et al., Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice [Correction]

26.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

MICROBIOLOGY Correction for “Effects of lymphocyte profile on development of EBV-induced lymphoma subtypes in humanized mice,” by Eun Kyung Lee, Eun Hye Joo, Kyung-A Song, Bongkum Choi, Miyoung Kim, Seok-Hyung Kim, Sung Joo Kim, and Myung-Soo Kang, which appeared in issue 42, October 20, 2015, of ...

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Correction for Bai et al., Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis [Correction]

26.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

BIOCHEMISTRY Correction for “Structural analysis of the dodecameric proteasome activator PafE in Mycobacterium tuberculosis,” by Lin Bai, Kuan Hu, Tong Wang, Jordan M. Jastrab, K. Heran Darwin, and Huilin Li, which appeared in issue 14, April 5, 2016, of Proc Natl Acad Sci USA (113:E1983–E1992; ...

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Evolution of the knowledge system for agricultural development in the Yaqui Valley, Sonora, Mexico [Sustainability Science]

26.04.2016 | Ellen B. McCullough; Pamela A. Matson, Proceedings of the National Academy of Sciences current issue, 2016

Knowledge systems—networks of linked actors, organizations, and objects that perform a number of knowledge-related functions that link knowledge and know how with action—have played a key role in fostering agricultural development over the last 50 years. We examine the evolution of the knowledge ...

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Covert neurofeedback without awareness shapes cortical network spontaneous connectivity [Neuroscience]

26.04.2016 | Michal Ramot; Shany Grossman; Doron Friedman; Rafael Malach, Proceedings of the National Academy of Sciences current issue, 2016

Recent advances in blood oxygen level-dependent–functional MRI (BOLD-fMRI)-based neurofeedback reveal that participants can modulate neuronal properties. However, it is unknown whether such training effects can be introduced in the absence of participants' awareness that they are being trained. ...

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Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity [Microbiology]

26.04.2016 | Monica Markovski; Jessica L. Bohrhunter; Tania J. Lupoli; Tsuyoshi Uehara; Suzanne Walker; Daniel E. Kahne; Thomas G ..., Proceedings of the National Academy of Sciences current issue, 2016

To fortify their cytoplasmic membrane and protect it from osmotic rupture, most bacteria surround themselves with a peptidoglycan (PG) exoskeleton synthesized by the penicillin-binding proteins (PBPs). As their name implies, these proteins are the targets of penicillin and related antibiotics. We ...

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The role of innovative global institutions in linking knowledge and action [Sustainability Science]

26.04.2016 | Lorrae van Kerkhoff; Nicole A. Szlezák, Proceedings of the National Academy of Sciences current issue, 2016

It is becoming increasingly recognized that our collective ability to tackle complex problems will require the development of new, adaptive, and innovative institutional arrangements that can deal with rapidly changing knowledge and have effective learning capabilities. In this paper, we applied ...

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Correction for Eastwood et al., Tissue mechanics govern the rapidly adapting and symmetrical response to touch [Correction]

26.04.2016 | Proceedings of the National Academy of Sciences current issue, 2016

NEUROSCIENCE, ENGINEERING Correction for “Tissue mechanics govern the rapidly adapting and symmetrical response to touch,” by Amy L. Eastwood, Alessandro Sanzeni, Bryan C. Petzold, Sung-Jin Park, Massimo Vergassola, Beth L. Pruitt, and Miriam B. Goodman, which appeared in issue 50, December 15, ...

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