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25.796 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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A normalization model suggests that attention changes the weighting of inputs between visual areas [Neuroscience]

16.05.2017 | Douglas A. Ruff; Marlene R. Cohen, Proceedings of the National Academy of Sciences current issue, 2017

Models of divisive normalization can explain the trial-averaged responses of neurons in sensory, association, and motor areas under a wide range of conditions, including how visual attention changes the gains of neurons in visual cortex. Attention, like other modulatory processes, is also ...

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Visual working memory buffers information retrieved from visual long-term memory [Psychological and Cognitive Sciences]

16.05.2017 | Keisuke Fukuda; Geoffrey F. Woodman, Proceedings of the National Academy of Sciences current issue, 2017

Human memory is thought to consist of long-term storage and short-term storage mechanisms, the latter known as working memory. Although it has long been assumed that information retrieved from long-term memory is represented in working memory, we lack neural evidence for this and need neural ...

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Oxytocin under opioid antagonism leads to supralinear enhancement of social attention [Psychological and Cognitive Sciences]

16.05.2017 | Olga Dal Monte; Matthew Piva; Kevin M. Anderson; Marios Tringides; Avram J. Holmes; Steve W. C. Chang, Proceedings of the National Academy of Sciences current issue, 2017

To provide new preclinical evidence toward improving the efficacy of oxytocin (OT) in treating social dysfunction, we tested the benefit of administering OT under simultaneously induced opioid antagonism during dyadic gaze interactions in monkeys. OT coadministered with a μ-opioid receptor ...

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Molecular mechanism of multispecific recognition of Calmodulin through conformational changes [Biochemistry]

16.05.2017 | Fei Liu; Xiakun Chu; H. Peter Lu; Jin Wang, Proceedings of the National Academy of Sciences current issue, 2017

Calmodulin (CaM) is found to have the capability to bind multiple targets. Investigations on the association mechanism of CaM to its targets are crucial for understanding protein–protein binding and recognition. Here, we developed a structure-based model to explore the binding process between CaM ...

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Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm [Cell Biology]

16.05.2017 | Nan-Peng Chen; Borhan Uddin; Robert Hardt; Wen Ding; Marko Panic; Ilaria Lucibello; Patricia Kammerer; Thomas Rupper ..., Proceedings of the National Academy of Sciences current issue, 2017

CDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae. Surprisingly, human CDC14A is not essential for cell cycle progression. Instead, it regulates cell migration and cell adhesion. Little is known ...

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Stability of bound species during alkene reactions on solid acids [Engineering]

16.05.2017 | Michele L. Sarazen; Enrique Iglesia, Proceedings of the National Academy of Sciences current issue, 2017

This study reports the thermodynamics of bound species derived from ethene, propene, n-butene, and isobutene on solid acids with diverse strength and confining voids. Density functional theory (DFT) and kinetic data indicate that covalently bound alkoxides form C–C bonds in the kinetically ...

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Biocompatible and totally disintegrable semiconducting polymer for ultrathin and ultralightweight transient electronics [Chemistry]

16.05.2017 | Ting Lei; Ming Guan; Jia Liu; Hung-Cheng Lin; Raphael Pfattner; Leo Shaw; Allister F. McGuire; Tsung-Ching Huang; Le ..., Proceedings of the National Academy of Sciences current issue, 2017

Increasing performance demands and shorter use lifetimes of consumer electronics have resulted in the rapid growth of electronic waste. Currently, consumer electronics are typically made with nondecomposable, nonbiocompatible, and sometimes even toxic materials, leading to serious ecological ...

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Universal transition from unstructured to structured neural maps [Neuroscience]

16.05.2017 | Marvin Weigand; Fabio Sartori; Hermann Cuntz, Proceedings of the National Academy of Sciences current issue, 2017

Neurons sharing similar features are often selectively connected with a higher probability and should be located in close vicinity to save wiring. Selective connectivity has, therefore, been proposed to be the cause for spatial organization in cortical maps. Interestingly, orientation preference ...

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Mechanism of signal propagation in Physarum polycephalum [Biophysics and Computational Biology]

16.05.2017 | Karen Alim; Natalie Andrew; Anne Pringle; Michael P. Brenner, Proceedings of the National Academy of Sciences current issue, 2017

Complex behaviors are typically associated with animals, but the capacity to integrate information and function as a coordinated individual is also a ubiquitous but poorly understood feature of organisms such as slime molds and fungi. Plasmodial slime molds grow as networks and use flexible, ...

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ILDR1 is important for paracellular water transport and urine concentration mechanism [Physiology]

16.05.2017 | Yongfeng Gong; Nina Himmerkus; Abby Sunq; Susanne Milatz; Cosima Merkel; Markus Bleich; Jianghui Hou, Proceedings of the National Academy of Sciences current issue, 2017

Whether the tight junction is permeable to water remains highly controversial. Here, we provide evidence that the tricellular tight junction is important for paracellular water permeation and that Ig-like domain containing receptor 1 (ILDR1) regulates its permeability. In the mouse kidney, ILDR1 ...

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