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23.316 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Chloroplast retrograde signal regulates flowering [Plant Biology]

20.09.2016 | Peiqiang Feng; Hailong Guo; Wei Chi; Xin Chai; Xuwu Sun; Xiumei Xu; Jinfang Ma; Jean-David Rochaix; Dario Leister; H ..., Proceedings of the National Academy of Sciences current issue, 2016

Light is a major environmental factor regulating flowering time, thus ensuring reproductive success of higher plants. In contrast to our detailed understanding of light quality and photoperiod mechanisms involved, the molecular basis underlying high light-promoted flowering remains elusive. Here ...

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PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line [Genetics]

20.09.2016 | Vipul Kumar; Frederick W. Alt; Richard L. Frock, Proceedings of the National Academy of Sciences current issue, 2016

Classical nonhomologous end joining (C-NHEJ) is a major mammalian DNA double-strand break (DSB) repair pathway. Core C-NHEJ factors, such as XRCC4, are required for joining DSB intermediates of the G1 phase-specific V(D)J recombination reaction in progenitor lymphocytes. Core factors also ...

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Circulating microRNA signature for the diagnosis of very high-risk prostate cancer [Medical Sciences]

20.09.2016 | Ali H. Alhasan; Alexander W. Scott; Jia J. Wu; Gang Feng; Joshua J. Meeks; C. Shad Thaxton; Chad A. Mirkin, Proceedings of the National Academy of Sciences current issue, 2016

We report the identification of a molecular signature using the Scano-miR profiling platform based on the differential expression of circulating microRNAs (miRNA, miR) in serum samples specific to patients with very high-risk (VHR) prostate cancer (PCa). Five miRNA PCa biomarkers (miR-200c, ...

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Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors [Immunology and Inflammation]

20.09.2016 | Daniel Silberman; Sai Harsha Krovi; Kathryn D. Tuttle; James Crooks; Richard Reisdorph; Janice White; James Gross; J ..., Proceedings of the National Academy of Sciences current issue, 2016

The interaction of αβ T-cell antigen receptors (TCRs) with peptides bound to MHC molecules lies at the center of adaptive immunity. Whether TCRs have evolved to react with MHC or, instead, processes in the thymus involving coreceptors and other molecules select MHC-specific TCRs de novo from a ...

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WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity [Biochemistry]

20.09.2016 | Qiuhong Li; Leifu Chang; Shintaro Aibara; Jing Yang; Ziguo Zhang; David Barford, Proceedings of the National Academy of Sciences current issue, 2016

The anaphase-promoting complex/cyclosome (APC/C) is a large multimeric cullin–RING E3 ubiquitin ligase that orchestrates cell-cycle progression by targeting cell-cycle regulatory proteins for destruction via the ubiquitin proteasome system. The APC/C assembly comprises two scaffolding ...

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Explosive ice age diversification of kiwi [Evolution]

20.09.2016 | Jason T. Weir; Oliver Haddrath; Hugh A. Robertson; Rogan M. Colbourne; Allan J. Baker, Proceedings of the National Academy of Sciences current issue, 2016

Molecular dating largely overturned the paradigm that global cooling during recent Pleistocene glacial cycles resulted in a burst of species diversification although some evidence exists that speciation was commonly promoted in habitats near the expanding and retracting ice sheets. Here, we used ...

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Pathological Ace2-to-Ace enzyme switch in the stressed heart is transcriptionally controlled by the endothelial Brg1-FoxM1 complex [Medical Sciences]

20.09.2016 | Jin Yang; Xuhui Feng; Qiong Zhou; Wei Cheng; Ching Shang; Pei Han; Chiou-Hong Lin; Huei-Sheng Vincent Chen; Thomas Q ..., Proceedings of the National Academy of Sciences current issue, 2016

Genes encoding angiotensin-converting enzymes (Ace and Ace2) are essential for heart function regulation. Cardiac stress enhances Ace, but suppresses Ace2, expression in the heart, leading to a net production of angiotensin II that promotes cardiac hypertrophy and fibrosis. The regulatory ...

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In This Issue [This Week in PNAS]

20.09.2016 | Proceedings of the National Academy of Sciences current issue, 2016

Tuberculosis and HIV coinfection SIV-infected cells in lung granuloma from macaque with extensive TB. One in three people harbor latent Mycobacterium tuberculosis (Mtb), the bacterium that causes tuberculosis (TB), but latent Mtb can trigger active TB. Coinfection with HIV can speed the ...

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Convergent evolution of caffeine in plants by co-option of exapted ancestral enzymes [Evolution]

20.09.2016 | Ruiqi Huang; Andrew J. O’Donnell; Jessica J. Barboline; Todd J. Barkman, Proceedings of the National Academy of Sciences current issue, 2016

Convergent evolution is a process that has occurred throughout the tree of life, but the historical genetic and biochemical context promoting the repeated independent origins of a trait is rarely understood. The well-known stimulant caffeine, and its xanthine alkaloid precursors, has evolved ...

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Spiny plants, mammal browsers, and the origin of African savannas [Ecology]

20.09.2016 | Tristan Charles-Dominique; T. Jonathan Davies; Gareth P. Hempson; Bezeng S. Bezeng; Barnabas H. Daru; Ronny M. Kabon ..., Proceedings of the National Academy of Sciences current issue, 2016

Savannas first began to spread across Africa during the Miocene. A major hypothesis for explaining this vegetation change is the increase in C4 grasses, promoting fire. We investigated whether mammals could also have contributed to savanna expansion by using spinescence as a marker of mammal ...

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