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27.239 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes [Medical Sciences]

31.10.2017 | Barbara Ludwig; Stefan Ludwig; Anja Steffen; Yvonne Knauf; Baruch Zimerman; Sophie Heinke; Susann Lehmann; Undine Sc ..., Proceedings of the National Academy of Sciences current issue, 2017

Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from ...

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Estradiol modulates the efficacy of synaptic inhibition by decreasing the dwell time of GABAA receptors at inhibitory synapses [Neuroscience]

31.10.2017 | Jayanta Mukherjee; Ross A. Cardarelli; Yasmine Cantaut-Belarif; Tarek Z. Deeb; Deepak P. Srivastava; Shiva K. Tyagar ..., Proceedings of the National Academy of Sciences current issue, 2017

Estrogen plays a critical role in many physiological processes and exerts profound effects on behavior by regulating neuronal excitability. While estrogen has been established to exert effects on dendritic morphology and excitatory neurotransmission its role in regulating neuronal inhibition is ...

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Across the tree of life, radiation resistance is governed by antioxidant Mn2+, gauged by paramagnetic resonance [Cell Biology]

31.10.2017 | Ajay Sharma; Elena K. Gaidamakova; Olga Grichenko; Vera Y. Matrosova; Veronika Hoeke; Polina Klimenkova; Isabel H. C ..., Proceedings of the National Academy of Sciences current issue, 2017

Despite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of ...

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In silico evidence for sequence-dependent nucleosome sliding [Biophysics and Computational Biology]

31.10.2017 | Joshua Lequieu; David C. Schwartz; Juan J. de Pablo, Proceedings of the National Academy of Sciences current issue, 2017

Nucleosomes represent the basic building block of chromatin and provide an important mechanism by which cellular processes are controlled. The locations of nucleosomes across the genome are not random but instead depend on both the underlying DNA sequence and the dynamic action of other proteins ...

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Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale [Microbiology]

31.10.2017 | Christophe Lemetre; Jeffrey Maniko; Zachary Charlop-Powers; Ben Sparrow; Andrew J. Lowe; Sean F. Brady, Proceedings of the National Academy of Sciences current issue, 2017

Although bacterial bioactive metabolites have been one of the most prolific sources of lead structures for the development of small-molecule therapeutics, very little is known about the environmental factors associated with changes in secondary metabolism across natural environments. Large-scale ...

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CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy [Medical Sciences]

31.10.2017 | Leyuan Ma; Jeffrey I. Boucher; Janet Paulsen; Sebastian Matuszewski; Christopher A. Eide; Jianhong Ou; Garrett Eicke ..., Proceedings of the National Academy of Sciences current issue, 2017

Developing tools to accurately predict the clinical prevalence of drug-resistant mutations is a key step toward generating more effective therapeutics. Here we describe a high-throughput CRISPR-Cas9–based saturated mutagenesis approach to generate comprehensive libraries of point mutations at a ...

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PAF1 complex component Leo1 helps recruit Drosophila Myc to promoters [Biochemistry]

31.10.2017 | Jennifer M. Gerlach; Michael Furrer; Maria Gallant; Dirk Birkel; Apoorva Baluapuri; Elmar Wolf; Peter Gallant, Proceedings of the National Academy of Sciences current issue, 2017

The Myc oncogene is a transcription factor with a powerful grip on cellular growth and proliferation. The physical interaction of Myc with the E-box DNA motif has been extensively characterized, but it is less clear whether this sequence-specific interaction is sufficient for Myc’s binding to its ...

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Correction for Pereira et al., Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing [Correction]

31.10.2017 | Proceedings of the National Academy of Sciences current issue, 2017

NEUROSCIENCE Correction for “Dorsolateral prefrontal cortex GABA deficit in older adults with sleep-disordered breathing,” by Ana C. Pereira, Xiangling Mao, Caroline S. Jiang, Guoxin Kang, Sara Milrad, Bruce S. McEwen, Ana C. Krieger, and Dikoma C. Shungu, which was first published September 5, ...

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Importance of a species’ socioecology: Wolves outperform dogs in a conspecific cooperation task [Psychological and Cognitive Sciences]

31.10.2017 | Sarah Marshall-Pescini; Jonas F. L. Schwarz; Inga Kostelnik; Zsófia Virányi; Friederike Range, Proceedings of the National Academy of Sciences current issue, 2017

A number of domestication hypotheses suggest that dogs have acquired a more tolerant temperament than wolves, promoting cooperative interactions with humans and conspecifics. This selection process has been proposed to resemble the one responsible for our own greater cooperative inclinations in ...

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Widespread covariation of early environmental exposures and trait-associated polygenic variation [Psychological and Cognitive Sciences]

31.10.2017 | E. Krapohl; L. J. Hannigan; J.-B. Pingault; H. Patel; N. Kadeva; C. Curtis; G. Breen; S. J. Newhouse; T. C. Eley; P. ..., Proceedings of the National Academy of Sciences current issue, 2017

Although gene–environment correlation is recognized and investigated by family studies and recently by SNP-heritability studies, the possibility that genetic effects on traits capture environmental risk factors or protective factors has been neglected by polygenic prediction models. We ...

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