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17.154 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [Plant Biology]

17.02.2015 | Siamsa M. Doyle; Ash Haeger; Thomas Vain; Adeline Rigal; Corrado Viotti; Małgorzata Łangowska; Qian Ma; Jiří Friml; ..., Proceedings of the National Academy of Sciences current issue, 2015

Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and abundance at the plasma membrane are ...

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Age-related immune clearance of hepatitis B virus infection requires the establishment of gut microbiota [Microbiology]

17.02.2015 | Han-Hsuan Chou; Wei-Hung Chien; Li-Ling Wu; Chi-Hung Cheng; Chen-Han Chung; Jau-Haw Horng; Yen-Hsuan Ni; Hong-Tai Ts ..., Proceedings of the National Academy of Sciences current issue, 2015

A unique feature of hepatitis B virus (HBV) infection in humans is that viral clearance heavily depends on the age of exposure. However, the reason for this remains unclear. Here we show that gut microbiota contribute to the age dependence of HBV immunity in a hydrodynamic transfection mouse ...

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Autoinhibition and relief mechanism for Polo-like kinase 4 [Cell Biology]

17.02.2015 | Joseph E. Klebba; Daniel W. Buster; Tiffany A. McLamarrah; Nasser M. Rusan; Gregory C. Rogers, Proceedings of the National Academy of Sciences current issue, 2015

Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication, and its hyperactivity induces centriole amplification. Homodimeric Plk4 has been shown to be ubiquitinated as a result of autophosphorylation, thus promoting its own degradation and preventing centriole amplification. ...

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Single liposome analysis of peptide translocation by the ABC transporter TAPL [Biophysics and Computational Biology]

17.02.2015 | Tina Zollmann; Gemma Moiset; Franz Tumulka; Robert Tampé; Bert Poolman; Rupert Abele, Proceedings of the National Academy of Sciences current issue, 2015

ATP-binding cassette (ABC) transporters use ATP to drive solute transport across biological membranes. Members of this superfamily have crucial roles in cell physiology, and some of the transporters are linked to severe diseases. However, understanding of the transport mechanism, especially of ...

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Haploinsufficiency screen highlights two distinct groups of ribosomal protein genes essential for embryonic stem cell fate [Genetics]

17.02.2015 | Simon Fortier; Tara MacRae; Mélanie Bilodeau; Tobias Sargeant; Guy Sauvageau, Proceedings of the National Academy of Sciences current issue, 2015

In a functional genomics screen of mouse embryonic stem cells (ESCs) with nested hemizygous chromosomal deletions, we reveal that ribosomal protein (RP) genes are the most significant haploinsufficient determinants for embryoid body (EB) formation. Hemizygocity for three RP genes (Rps5, Rps14, or ...

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An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin [Microbiology]

17.02.2015 | Kristin R. Wade; Eileen M. Hotze; Michael J. Kuiper; Craig J. Morton; Michael W. Parker; Rodney K. Tweten, Proceedings of the National Academy of Sciences current issue, 2015

β-Barrel pore-forming toxins (βPFTs) form an obligatory oligomeric prepore intermediate before the formation of the β-barrel pore. The molecular components that control the critical prepore-to-pore transition remain unknown for βPFTs. Using the archetype βPFT perfringolysin O, we show that E183 ...

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Mandibular evidence supports Homo floresiensis as a distinct species [Physical Sciences]

17.02.2015 | Michael Carrington Westaway; Arthur C. Durband; Colin P. Groves; Mark Collard, Proceedings of the National Academy of Sciences current issue, 2015

Henneberg et al. (1) and Eckhardt et al. (2) present another pathology-based alternative to the hypothesis that the “hobbit” fossils from Liang Bua, Indonesia, represent a distinct hominin species, Homo floresiensis. They contend that the Liang Bua specimens are the remains of small-bodied humans ...

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Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum [Biochemistry]

17.02.2015 | Filipa Teixeira; Helena Castro; Tânia Cruz; Eric Tse; Philipp Koldewey; Daniel R. Southworth; Ana M. Tomás; Ursula Jakob, Proceedings of the National Academy of Sciences current issue, 2015

Cytosolic eukaryotic 2-Cys-peroxiredoxins have been widely reported to act as dual-function proteins, either detoxifying reactive oxygen species or acting as chaperones to prevent protein aggregation. Several stimuli, including peroxide-mediated sulfinic acid formation at the active site ...

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Structural basis for transcription reactivation by RapA [Biochemistry]

17.02.2015 | Bin Liu; Yuhong Zuo; Thomas A. Steitz, Proceedings of the National Academy of Sciences current issue, 2015

RNA polymerase (RNAP) loses activity during transcription as it stalls at various inactive states due to erratic translocation. Reactivation of these stalled RNAPs is essential for efficient RNA synthesis. Here we report a 4.7-Å resolution crystal structure of the Escherichia coli RNAP core ...

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Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies [Applied Biological Sciences]

17.02.2015 | Dario Venetz; Christian Hess; Chia-wei Lin; Markus Aebi; Dario Neri, Proceedings of the National Academy of Sciences current issue, 2015

The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we ...

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