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26.772 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Exposure to and recall of violence reduce short-term memory and cognitive control [Psychological and Cognitive Sciences]

08.08.2017 | Francesco Bogliacino; Gianluca Grimalda; Pietro Ortoleva; Patrick Ring, Proceedings of the National Academy of Sciences current issue, 2017

Previous research has investigated the effects of violence and warfare on individuals' well-being, mental health, and individual prosociality and risk aversion. This study establishes the short- and long-term effects of exposure to violence on short-term memory and aspects of cognitive control. ...

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Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies [Immunology and Inflammation]

08.08.2017 | Joyce K. Hwang; Chong Wang; Zhou Du; Robin M. Meyers; Thomas B. Kepler; Donna Neuberg; Peter D. Kwong; John R. Masco ..., Proceedings of the National Academy of Sciences current issue, 2017

Variable regions of Ig chains provide the antigen recognition portion of B-cell receptors and derivative antibodies. Ig heavy-chain variable region exons are assembled developmentally from V, D, J gene segments. Each variable region contains three antigen-contacting complementarity-determining ...

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Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma [Medical Sciences]

08.08.2017 | Nan Li; Haiying Fu; Stephen M. Hewitt; Dimiter S. Dimitrov; Mitchell Ho, Proceedings of the National Academy of Sciences current issue, 2017

Neuroblastoma is a childhood cancer that is fatal in almost half of patients despite intense multimodality treatment. This cancer is derived from neuroendocrine tissue located in the sympathetic nervous system. Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan that is important for ...

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Buying time promotes happiness [Social Sciences]

08.08.2017 | Ashley V. Whillans; Elizabeth W. Dunn; Paul Smeets; Rene Bekkers; Michael I. Norton, Proceedings of the National Academy of Sciences current issue, 2017

Around the world, increases in wealth have produced an unintended consequence: a rising sense of time scarcity. We provide evidence that using money to buy time can provide a buffer against this time famine, thereby promoting happiness. Using large, diverse samples from the United States, Canada, ...

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Synthetic quorum sensing in model microcapsule colonies [Engineering]

08.08.2017 | Henry Shum; Anna C. Balazs, Proceedings of the National Academy of Sciences current issue, 2017

Biological quorum sensing refers to the ability of cells to gauge their population density and collectively initiate a new behavior once a critical density is reached. Designing synthetic materials systems that exhibit quorum sensing-like behavior could enable the fabrication of devices with both ...

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SUMOylation determines the voltage required to activate cardiac IKs channels [Physiology]

08.08.2017 | Dazhi Xiong; Tian Li; Hui Dai; Anthony F. Arena; Leigh D. Plant; Steve A. N. Goldstein, Proceedings of the National Academy of Sciences current issue, 2017

IKs channels open in response to depolarization of the membrane voltage during the cardiac action potential, passing potassium ions outward to repolarize ventricular myocytes and end each beat. Here, we show that the voltage required to activate IKs channels depends on their covalent modification ...

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Ubiquitination of exposed glycoproteins by SCFFBXO27 directs damaged lysosomes for autophagy [Cell Biology]

08.08.2017 | Yukiko Yoshida; Sayaka Yasuda; Toshiharu Fujita; Maho Hamasaki; Arisa Murakami; Junko Kawawaki; Kazuhiro Iwai; Yasus ..., Proceedings of the National Academy of Sciences current issue, 2017

Ubiquitination functions as a signal to recruit autophagic machinery to damaged organelles and induce their clearance. Here, we report the characterization of FBXO27, a glycoprotein-specific F-box protein that is part of the SCF (SKP1/CUL1/F-box protein) ubiquitin ligase complex, and demonstrate ...

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An invasive foundation species enhances multifunctionality in a coastal ecosystem [Sustainability Science]

08.08.2017 | Aaron P. Ramus; Brian R. Silliman; Mads S. Thomsen; Zachary T. Long, Proceedings of the National Academy of Sciences current issue, 2017

While invasive species often threaten biodiversity and human well-being, their potential to enhance functioning by offsetting the loss of native habitat has rarely been considered. We manipulated the abundance of the nonnative, habitat-forming seaweed Gracilaria vermiculophylla in large plots (25 ...

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Nature does not rely on long-lived electronic quantum coherence for photosynthetic energy transfer [Physics]

08.08.2017 | Hong-Guang Duan; Valentyn I. Prokhorenko; Richard J. Cogdell; Khuram Ashraf; Amy L. Stevens; Michael Thorwart; R. J. ..., Proceedings of the National Academy of Sciences current issue, 2017

During the first steps of photosynthesis, the energy of impinging solar photons is transformed into electronic excitation energy of the light-harvesting biomolecular complexes. The subsequent energy transfer to the reaction center is commonly rationalized in terms of excitons moving on a grid of ...

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Structural organization of the actin-spectrin-based membrane skeleton in dendrites and soma of neurons [Neuroscience]

08.08.2017 | Boran Han; Ruobo Zhou; Chenglong Xia; Xiaowei Zhuang, Proceedings of the National Academy of Sciences current issue, 2017

Actin, spectrin, and associated molecules form a membrane-associated periodic skeleton (MPS) in neurons. In the MPS, short actin filaments, capped by actin-capping proteins, form ring-like structures that wrap around the circumference of neurites, and these rings are periodically spaced along the ...

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