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23.044 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Salmonella Typhimurium utilizes a T6SS-mediated antibacterial weapon to establish in the host gut [Microbiology]

23.08.2016 | Thibault G. Sana; Nicolas Flaugnatti; Kyler A. Lugo; Lilian H. Lam; Amanda Jacobson; Virginie Baylot; Eric Durand; L ..., Proceedings of the National Academy of Sciences current issue, 2016

The mammalian gastrointestinal tract is colonized by a high-density polymicrobial community where bacteria compete for niches and resources. One key competition strategy includes cell contact-dependent mechanisms of interbacterial antagonism, such as the type VI secretion system (T6SS), a ...

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Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound {alpha}2 homopentamer [Neuroscience]

23.08.2016 | Nikolaos Kouvatsos; Petros Giastas; Dafni Chroni-Tzartou; Cornelia Poulopoulou; Socrates J. Tzartos, Proceedings of the National Academy of Sciences current issue, 2016

In this study we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal α2 nicotinic acetylcholine receptor (nAChR) subunit in complex with the agonist epibatidine at 3.2 Å. Interestingly, α2 was crystallized as a pentamer, revealing the intersubunit ...

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Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure [Biochemistry]

23.08.2016 | Jun Suzuki; Eiichi Imanishi; Shigekazu Nagata, Proceedings of the National Academy of Sciences current issue, 2016

Xk-related protein (Xkr) 8, a protein carrying 10 transmembrane regions, is essential for scrambling phospholipids during apoptosis. Here, we found Xkr8 as a complex with basigin (BSG) or neuroplastin (NPTN), type I membrane proteins in the Ig superfamily. In BSG−/−NPTN−/− cells, Xkr8 localized ...

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Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis [Microbiology]

23.08.2016 | Md Saruar Bhuiyan; Felix Ellett; Gerald L. Murray; Xenia Kostoulias; Gustavo M. Cerqueira; Keith E. Schulze; Mohd Ha ..., Proceedings of the National Academy of Sciences current issue, 2016

Innate cellular immune responses are a critical first-line defense against invading bacterial pathogens. Leukocyte migration from the bloodstream to a site of infection is mediated by chemotactic factors that are often host-derived. More recently, there has been a greater appreciation of the ...

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Gram-negative trimeric porins have specific LPS binding sites that are essential for porin biogenesis [Microbiology]

23.08.2016 | Wanatchaporn Arunmanee; Monisha Pathania; Alexandra S. Solovyova; Anton P. Le Brun; Helen Ridley; Arnaud Baslé; Bert ..., Proceedings of the National Academy of Sciences current issue, 2016

The outer membrane (OM) of gram-negative bacteria is an unusual asymmetric bilayer with an external monolayer of lipopolysaccharide (LPS) and an inner layer of phospholipids. The LPS layer is rigid and stabilized by divalent cation cross-links between phosphate groups on the core oligosaccharide ...

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Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein {alpha}-synuclein [Medical Sciences]

23.08.2016 | Wei Wang; Linh T. T. Nguyen; Christopher Burlak; Fariba Chegini; Feng Guo; Tim Chataway; Shulin Ju; Oriana S. Fisher ..., Proceedings of the National Academy of Sciences current issue, 2016

The aggregation of α-synuclein (aSyn) leading to the formation of Lewy bodies is the defining pathological hallmark of Parkinson’s disease (PD). Rare familial PD-associated mutations in aSyn render it aggregation-prone; however, PD patients carrying wild type (WT) aSyn also have aggregated aSyn ...

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Reply to Varma: Elucidation of the signal origin for label-free, free-solution interactions [Physical Sciences]

23.08.2016 | Darryl J. Bornhop; Michael N. Kammer; Amanda Kussrow; Robert A. Flowers II, Proceedings of the National Academy of Sciences current issue, 2016

In response to the letter submitted by Varma (1), we respectfully disagree with the assertion that our proposed free-solution response function (FreeSRF) model (2) does not explain the signal origin for free-solution measurements. His theoretical considerations are appreciated; however, as we ...

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DNA damage checkpoint kinase ATM regulates germination and maintains genome stability in seeds [Plant Biology]

23.08.2016 | Wanda M. Waterworth; Steven Footitt; Clifford M. Bray; William E. Finch-Savage; Christopher E. West, Proceedings of the National Academy of Sciences current issue, 2016

Genome integrity is crucial for cellular survival and the faithful transmission of genetic information. The eukaryotic cellular response to DNA damage is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTATED (ATM) and ATM AND RAD3-RELATED (ATR). Here we identify ...

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In This Issue [This Week in PNAS]

23.08.2016 | Proceedings of the National Academy of Sciences current issue, 2016

3D structure of Alzheimer’s disease-associated amyloid fibril The 3D NMR structure of the Aβ(1–42) fibrils is shown in a ribbon representation with each individual molecule colored differently in front of a [13C,13C]-correlation NMR spectrum. Alzheimer’s disease (AD) is characterized by the ...

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Near-atomic cryo-EM structure of PRC1 bound to the microtubule [Biophysics and Computational Biology]

23.08.2016 | Elizabeth H. Kellogg; Stuart Howes; Shih-Chieh Ti; Erney Ramírez-Aportela; Tarun M. Kapoor; Pablo Chacón; Eva Nogales, Proceedings of the National Academy of Sciences current issue, 2016

Proteins that associate with microtubules (MTs) are crucial to generate MT arrays and establish different cellular architectures. One example is PRC1 (protein regulator of cytokinesis 1), which cross-links antiparallel MTs and is essential for the completion of mitosis and cytokinesis. Here we ...

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