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27.074 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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The 4E-BP growth pathway regulates the effect of ambient temperature on Drosophila metabolism and lifespan [Physiology]

05.09.2017 | Gil B. Carvalho; Ilaria Drago; Sany Hoxha; Ryuichi Yamada; Olena Mahneva; Kimberley D. Bruce; Alina Soto Obando; Bru ..., Proceedings of the National Academy of Sciences current issue, 2017

Changes in body temperature can profoundly affect survival. The dramatic longevity-enhancing effect of cold has long been known in organisms ranging from invertebrates to mammals, yet the underlying mechanisms have only recently begun to be uncovered. In the nematode Caenorhabditis elegans, this ...

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Designed metalloenediyne warheads damage DNA and outpace DNA polymerase [Chemistry]

05.09.2017 | Martin L. Kirk, Proceedings of the National Academy of Sciences current issue, 2017

Normal cells eventually undergo a highly regulated process of programmed cell death, or apoptosis, while abnormalities in this process may lead to uncontrolled cell proliferation and cancer. Cancer cells differ from normal cells with respect to their resistance to signals that control both cell ...

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Targeted PET imaging strategy to differentiate malignant from inflamed lymph nodes in diffuse large B-cell lymphoma [Applied Biological Sciences]

05.09.2017 | Jun Tang; Darin Salloum; Brandon Carney; Christian Brand; Susanne Kossatz; Ahmad Sadique; Jason S. Lewis; Wolfgang A ..., Proceedings of the National Academy of Sciences current issue, 2017

Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adults. DLBCL exhibits highly aggressive and systemic progression into multiple tissues in patients, particularly in lymph nodes. Whole-body 18F-fluodeoxyglucose positron emission tomography ([18F]FDG-PET) imaging has an ...

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Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction [Physiology]

05.09.2017 | Rigo Cintron-Colon; Manuel Sanchez-Alavez; William Nguyen; Simone Mori; Ruben Gonzalez-Rivera; Tiffany Lien; Tamas B ..., Proceedings of the National Academy of Sciences current issue, 2017

When food resources are scarce, endothermic animals can lower core body temperature (Tb). This phenomenon is believed to be part of an adaptive mechanism that may have evolved to conserve energy until more food becomes available. Here, we found in the mouse that the insulin-like growth factor 1 ...

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In situ nano- to microscopic imaging and growth mechanism of electrochemical dissolution (e.g., corrosion) of a confined metal surface [Chemistry]

05.09.2017 | C. Merola; H.-W. Cheng; K. Schwenzfeier; K. Kristiansen; Y.-J. Chen; H. A. Dobbs; J. N. Israelachvili; M. Valtiner, Proceedings of the National Academy of Sciences current issue, 2017

Reactivity in confinement is central to a wide range of applications and systems, yet it is notoriously difficult to probe reactions in confined spaces in real time. Using a modified electrochemical surface forces apparatus (EC-SFA) on confined metallic surfaces, we observe in situ nano- to ...

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Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope [Microbiology]

05.09.2017 | Yan Wu; Yaohua Zhu; Feng Gao; Yongjun Jiao; Babayemi O. Oladejo; Yan Chai; Yuhai Bi; Shan Lu; Mengqiu Dong; Chang Zh ..., Proceedings of the National Academy of Sciences current issue, 2017

Severe fever with thrombocytopenia syndrome virus (SFTSV) and Rift Valley fever virus (RVFV) are two arthropod-borne phleboviruses in the Bunyaviridae family, which cause severe illness in humans and animals. Glycoprotein N (Gn) is one of the envelope proteins on the virus surface and is a major ...

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Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G [Medical Sciences]

05.09.2017 | Alice Emptoz; Vincent Michel; Andrea Lelli; Omar Akil; Jacques Boutet de Monvel; Ghizlene Lahlou; Anaïs Meyer; Typha ..., Proceedings of the National Academy of Sciences current issue, 2017

Our understanding of the mechanisms underlying inherited forms of inner ear deficits has considerably improved during the past 20 y, but we are still far from curative treatments. We investigated gene replacement as a strategy for restoring inner ear functions in a mouse model of Usher syndrome ...

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Coevolutionary arms race versus host defense chase in a tropical herbivore-plant system [Evolution]

05.09.2017 | María-José Endara; Phyllis D. Coley; Gabrielle Ghabash; James A. Nicholls; Kyle G. Dexter; David A. Donoso; Graham N ..., Proceedings of the National Academy of Sciences current issue, 2017

Coevolutionary models suggest that herbivores drive diversification and community composition in plants. For herbivores, many questions remain regarding how plant defenses shape host choice and community structure. We addressed these questions using the tree genus Inga and its lepidopteran ...

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Prion protein {beta}2-{alpha}2 loop conformational landscape [Biophysics and Computational Biology]

05.09.2017 | Enrico Caldarulo; Alessandro Barducci; Kurt Wüthrich; Michele Parrinello, Proceedings of the National Academy of Sciences current issue, 2017

In transmissible spongiform encephalopathies (TSEs), which are lethal neurodegenerative diseases that affect humans and a wide range of other mammalian species, the normal “cellular” prion protein (PrPC) is transformed into amyloid aggregates representing the “scrapie form” of the protein ...

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Correction for Kidger et al., Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling [Correction]

05.09.2017 | Proceedings of the National Academy of Sciences current issue, 2017

CELL BIOLOGY Correction for “Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling,” by Andrew M. Kidger, Linda K. Rushworth, Julia Stellzig, Jane Davidson, Christopher J. Bryant, Cassidy Bayley, Edward Caddye, Tim Rogers, ...

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