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17.616 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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SWI/SNF chromatin-remodeling complexes function in noncoding RNA-dependent assembly of nuclear bodies [Biochemistry]

07.04.2015 | Tetsuya Kawaguchi; Akie Tanigawa; Takao Naganuma; Yasuyuki Ohkawa; Sylvie Souquere; Gerard Pierron; Tetsuro Hirose, Proceedings of the National Academy of Sciences current issue, 2015

Paraspeckles are subnuclear structures that form around nuclear paraspeckle assembly transcript 1 (NEAT1) long noncoding RNA (lncRNA). Recently, paraspeckles were shown to be functional nuclear bodies involved in stress responses and the development of specific organs. Paraspeckle formation is ...

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Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes [Immunology and Inflammation]

07.04.2015 | Tim Willinger; Matthew Staron; Shawn M. Ferguson; Pietro De Camilli; Richard A. Flavell, Proceedings of the National Academy of Sciences current issue, 2015

Prolonged T-cell receptor (TCR) signaling is required for the proliferation of T lymphocytes. Ligation of the TCR activates signaling, but also causes internalization of the TCR from the cell surface. How TCR signaling is sustained for many hours despite lower surface expression is unknown. Using ...

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Molecular coevolution of a sex pheromone and its receptor triggers reproductive isolation in Schizosaccharomyces pombe [Genetics]

07.04.2015 | Taisuke Seike; Taro Nakamura; Chikashi Shimoda, Proceedings of the National Academy of Sciences current issue, 2015

The diversification of sex pheromones is regarded as one of the causes of prezygotic isolation that results in speciation. In the fission yeast Schizosaccharomyces pombe, the molecular recognition of a peptide pheromone by its receptor plays an essential role in sexual reproduction. We considered ...

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Single-molecule analysis of RAG-mediated V(D)J DNA cleavage [Biophysics and Computational Biology]

07.04.2015 | Geoffrey A. Lovely; Robert C. Brewster; David G. Schatz; David Baltimore; Rob Phillips, Proceedings of the National Academy of Sciences current issue, 2015

The recombination-activating gene products, RAG1 and RAG2, initiate V(D)J recombination during lymphocyte development by cleaving DNA adjacent to conserved recombination signal sequences (RSSs). The reaction involves DNA binding, synapsis, and cleavage at two RSSs located on the same DNA molecule ...

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Using wavelength and slope to infer the historical origin of semiarid vegetation bands [Ecology]

07.04.2015 | Jonathan A. Sherratt, Proceedings of the National Academy of Sciences current issue, 2015

Landscape-scale patterns of vegetation occur worldwide at interfaces between semiarid and arid climates. They are important as potential indicators of climate change and imminent regime shifts and are widely thought to arise from positive feedback between vegetation and infiltration of rainwater. ...

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TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+ T cell epitopes [Medical Sciences]

07.04.2015 | Diego Chowell; Sri Krishna; Pablo D. Becker; Clément Cocita; Jack Shu; Xuefang Tan; Philip D. Greenberg; Linda S. Kl ..., Proceedings of the National Academy of Sciences current issue, 2015

Despite the availability of major histocompatibility complex (MHC)-binding peptide prediction algorithms, the development of T-cell vaccines against pathogen and tumor antigens remains challenged by inefficient identification of immunogenic epitopes. CD8+ T cells must distinguish immunogenic ...

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TRAPPII regulates exocytic Golgi exit by mediating nucleotide exchange on the Ypt31 ortholog RabERAB11 [Cell Biology]

07.04.2015 | Mario Pinar; Herbert N. Arst Jr.; Areti Pantazopoulou; Víctor G. Tagua; Vivian de los Ríos; Javier Rodríguez-Salaric ..., Proceedings of the National Academy of Sciences current issue, 2015

The oligomeric complex transport protein particle I (TRAPPI) mediates nucleotide exchange on the RAB GTPase RAB1/Ypt1. TRAPPII is composed of TRAPPI plus three additional subunits, Trs120, Trs130, and Trs65. Unclear is whether TRAPPII mediates nucleotide exchange on RAB1/Ypt1, RAB11/Ypt31, or ...

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Cross-talk between PKA-C{beta} and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi [Pharmacology]

07.04.2015 | Seiko Susuki-Miyata; Masanori Miyata; Byung-Cheol Lee; Haidong Xu; Hirofumi Kai; Chen Yan; Jian-Dong Li, Proceedings of the National Academy of Sciences current issue, 2015

Phosphodiesterase 4B (PDE4B) plays a key role in regulating inflammation. Roflumilast, a phosphodiesterase (PDE)4-selective inhibitor, has recently been approved for treating severe chronic obstructive pulmonary disease (COPD) patients with exacerbation. However, there is also clinical evidence ...

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A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography [Biochemistry]

07.04.2015 | Richard D. Bunker; Kalyaneswar Mandal; Ghader Bashiri; Jessica J. Chaston; Bradley L. Pentelute; J. Shaun Lott; Step ..., Proceedings of the National Academy of Sciences current issue, 2015

Protein 3D structure can be a powerful predictor of function, but it often faces a critical roadblock at the crystallization step. Rv1738, a protein from Mycobacterium tuberculosis that is strongly implicated in the onset of nonreplicating persistence, and thereby latent tuberculosis, resisted ...

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Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex [Microbiology]

07.04.2015 | Maher Alayyoubi; George P. Leser; Christopher A. Kors; Robert A. Lamb, Proceedings of the National Academy of Sciences current issue, 2015

Parainfluenza virus 5 (PIV5) is a member of the Paramyxoviridae family of membrane-enveloped viruses with a negative-sense RNA genome that is packaged and protected by long filamentous nucleocapsid-helix structures (RNPs). These RNPs, consisting of ∼2,600 protomers of nucleocapsid (N) protein, ...

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