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14.006 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Reply to Giri and Long: Freeze-mediated expansion of mangroves does not depend on whether expansion is emergence or reemergence [Biological Sciences]

15.04.2014 | Kyle C. Cavanaugh; James R. Kellner; Alexander J. Forde; Daniel S. Gruner; John D. Parker; Wilfrid Rodriguez; Ilka C ..., Proceedings of the National Academy of Sciences current issue, 2014

Giri and Long (1) agree with our conclusion (2) that the expansion of mangroves from 1984 to 2011 near their range limit on the Atlantic coast of Florida is a threshold response to fewer days below −4 °C. However, they suggest that our conclusions would have been “substantially different” had...

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Deoxygenation of the Baltic Sea during the last century [Ecology]

15.04.2014 | Jacob Carstensen; Jesper H. Andersen; Bo G. Gustafsson; Daniel J. Conley, Proceedings of the National Academy of Sciences current issue, 2014

Deoxygenation is a global problem in coastal and open regions of the ocean, and has led to expanding areas of oxygen minimum zones and coastal hypoxia. The recent expansion of hypoxia in coastal ecosystems has been primarily attributed to global warming and enhanced nutrient input from land and ...

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CD133 might be a pan marker of epithelial cells with dedifferentiation capacity [Biological Sciences]

15.04.2014 | Denis Corbeil; Christine A. Fargeas; József Jászai, Proceedings of the National Academy of Sciences current issue, 2014

Kusaba et al. provide additional evidence using genetic lineage analysis that epithelial cell dedifferentiation is responsible for repair of proximal tubules after injury in mouse (1). These data challenge the hypothesis of the implication of scattered stem cells in such a process or highlight a ...

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Correction for Dong et al., Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates [Correction]

15.04.2014 | Proceedings of the National Academy of Sciences current issue, 2014

ENGINEERING Correction for “Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates,” by Yizhou Dong, Kevin T. Love, J. Robert Dorkin, Sasilada Sirirungruang, Yunlong Zhang, Delai Chen, Roman L. Bogorad, Hao Yin, Yi Chen, Arturo J. Vegas, Christopher A. ...

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Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis [Biochemistry]

15.04.2014 | Vincent S. Tagliabracci; James L. Engel; Sandra E. Wiley; Junyu Xiao; David J. Gonzalez; Hitesh Nidumanda Appaiah; A ..., Proceedings of the National Academy of Sciences current issue, 2014

The family with sequence similarity 20, member C (Fam20C) has recently been identified as the Golgi casein kinase. Fam20C phosphorylates secreted proteins on Ser-x-Glu/pSer motifs and loss-of-function mutations in the kinase cause Raine syndrome, an often-fatal osteosclerotic bone dysplasia. ...

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The docking protein FRS2{alpha} is a critical regulator of VEGF receptors signaling [Biochemistry]

15.04.2014 | Pei-Yu Chen; Lingfeng Qin; Zhen W. Zhuang; George Tellides; Irit Lax; Joseph Schlessinger; Michael Simons, Proceedings of the National Academy of Sciences current issue, 2014

Vascular endothelial growth factors (VEGFs) signal via their cognate receptor tyrosine kinases designated VEGFR1-3. We report that the docking protein fibroblast growth factor receptor substrate 2 (FRS2α) plays a critical role in cell signaling via these receptors. In vitro FRS2α regulates VEGF-A ...

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Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice [Physiology]

15.04.2014 | Huizhen Wang; Melissa Larson; Albina Jablonka-Shariff; Christopher A. Pearl; William L. Miller; P. Michael Conn; Irv ..., Proceedings of the National Academy of Sciences current issue, 2014

FSH and luteinizing hormone (LH) are secreted constitutively or in pulses, respectively, from pituitary gonadotropes in many vertebrates, and regulate ovarian function. The molecular basis for this evolutionarily conserved gonadotropin-specific secretion pattern is not understood. Here, we show ...

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Correction for Kusaba et al., Differentiated kidney epithelial cells repair injured proximal tubule [Correction]

15.04.2014 | Proceedings of the National Academy of Sciences current issue, 2014

MEDICAL SCIENCES Correction for “Differentiated kidney epithelial cells repair injured proximal tubule,” by Tetsuro Kusaba, Matthew Lalli, Rafael Kramann, Akio Kobayashi, and Benjamin D. Humphreys, which appeared in issue 4, January 28, 2014, of Proc Natl Acad Sci USA (111:1527–1532; first ...

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Thermal-safety margins and the necessity of thermoregulatory behavior across latitude and elevation [Ecology]

15.04.2014 | Jennifer M. Sunday; Amanda E. Bates; Michael R. Kearney; Robert K. Colwell; Nicholas K. Dulvy; John T. Longino; Raym ..., Proceedings of the National Academy of Sciences current issue, 2014

Physiological thermal-tolerance limits of terrestrial ectotherms often exceed local air temperatures, implying a high degree of thermal safety (an excess of warm or cold thermal tolerance). However, air temperatures can be very different from the equilibrium body temperature of an individual ...

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Chronology in lesion tolerance gives priority to genetic variability [Biochemistry]

15.04.2014 | Karel Naiman; Gaëlle Philippin; Robert P. Fuchs; Vincent Pagès, Proceedings of the National Academy of Sciences current issue, 2014

The encounter of a replication fork with a blocking DNA lesion is a common event that cells need to address properly to preserve genome integrity. Cells possess two main strategies to tolerate unrepaired lesions: potentially mutagenic translesion synthesis (TLS) and nonmutagenic damage avoidance ...

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