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24.553 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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The global decline of cheetah Acinonyx jubatus and what it means for conservation [Ecology]

17.01.2017 | Sarah M. Durant; Nicholas Mitchell; Rosemary Groom; Nathalie Pettorelli; Audrey Ipavec; Andrew P. Jacobson; Rosie Wo ..., Proceedings of the National Academy of Sciences current issue, 2017

Establishing and maintaining protected areas (PAs) are key tools for biodiversity conservation. However, this approach is insufficient for many species, particularly those that are wide-ranging and sparse. The cheetah Acinonyx jubatus exemplifies such a species and faces extreme challenges to its ...

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Directional emission from dye-functionalized plasmonic DNA superlattice microcavities [Chemistry]

17.01.2017 | Daniel J. Park; Jessie C. Ku; Lin Sun; Clotilde M. Lethiec; Nathaniel P. Stern; George C. Schatz; Chad A. Mirkin, Proceedings of the National Academy of Sciences current issue, 2017

Three-dimensional plasmonic superlattice microcavities, made from programmable atom equivalents comprising gold nanoparticles functionalized with DNA, are used as a testbed to study directional light emission. DNA-guided nanoparticle colloidal crystallization allows for the formation of ...

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CD74 is a novel transcription regulator [Immunology and Inflammation]

17.01.2017 | Naama Gil-Yarom; Lihi Radomir; Lital Sever; Matthias P. Kramer; Hadas Lewinsky; Chamutal Bornstein; Ronnie Blecher-G ..., Proceedings of the National Academy of Sciences current issue, 2017

CD74 is a cell-surface receptor for the cytokine macrophage migration inhibitory factor. Macrophage migration inhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic intracellular domain (CD74–ICD), which regulates cell survival. In the present study, ...

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When protected areas prove insufficient: Cheetah and “protection-reliant” species [Ecology]

17.01.2017 | Joshua R. Ginsberg, Proceedings of the National Academy of Sciences current issue, 2017

An understanding of the factors that affect the distribution of species is a cornerstone of ecology; yet, two-thirds of the world’s species remain undescribed (1) and estimated rates of extinction are high, but certainty around those rates is limited (2). The International Union for Conservation ...

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Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity [Neuroscience]

17.01.2017 | Minshu Li; Zhiguo Li; Yang Yao; Wei-Na Jin; Kristofer Wood; Qiang Liu; Fu-Dong Shi; Junwei Hao, Proceedings of the National Academy of Sciences current issue, 2017

Astrocytes are believed to bridge interactions between infiltrating lymphocytes and neurons during brain ischemia, but the mechanisms for this action are poorly understood. Here we found that interleukin-15 (IL-15) is dramatically up-regulated in astrocytes of postmortem brain tissues from ...

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Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4 [Biochemistry]

17.01.2017 | Irina F. Sevrioukova; Thomas L. Poulos, Proceedings of the National Academy of Sciences current issue, 2017

Human cytochrome P450 3A4 (CYP3A4) is a major hepatic and intestinal enzyme that oxidizes more than 60% of administered therapeutics. Knowledge of how CYP3A4 adjusts and reshapes the active site to regioselectively oxidize chemically diverse compounds is critical for better understanding ...

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Correction for Lin et al., DNA polymerase {zeta} limits chromosomal damage and promotes cell survival following aflatoxin exposure [Correction]

17.01.2017 | Proceedings of the National Academy of Sciences current issue, 2017

CELL BIOLOGY Correction for “DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure,” by Ying-Chih Lin, Nichole Owen, Irina G. Minko, Sabine S. Lange, Liang Li, Michael P. Stone, Richard D. Wood, Amanda K. McCullough, and R. Stephen Lloyd, which ...

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When bottom-up meets top-down [Applied Physical Sciences]

17.01.2017 | Zvi Shtein; Oded Shoseyov, Proceedings of the National Academy of Sciences current issue, 2017

Top-Down Man-Made Vs. Bottom-Up Nature In nature, materials are built in a “bottom-up” manner, relying on the self-assembly of fundamental building blocks, and have evolved over thousands of years of natural selection to achieve impressive performance. Materials in nature are sustainably designed ...

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Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes [Applied Physical Sciences]

17.01.2017 | Zhen Song; Zhilin Qu; Alain Karma, Proceedings of the National Academy of Sciences current issue, 2017

Cardiac myocytes normally initiate action potentials in response to a current stimulus that depolarizes the membrane above an excitation threshold. Aberrant excitation can also occur due to spontaneous calcium (Ca2+) release (SCR) from intracellular stores after the end of a preceding action ...

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Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation [Immunology and Inflammation]

17.01.2017 | William A. McEwan; Benjamin Falcon; Marina Vaysburd; Dean Clift; Adrian L. Oblak; Bernardino Ghetti; Michel Goedert; ..., Proceedings of the National Academy of Sciences current issue, 2017

Alzheimer’s disease (AD) and other neurodegenerative disorders are associated with the cytoplasmic aggregation of microtubule-associated protein tau. Recent evidence supports transcellular transfer of tau misfolding (seeding) as the mechanism of spread within an affected brain, a process ...

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