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16.614 Aktuelle Fachpublikationen in Proceedings of the National Academy of Sciences current issue

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Economic optimization of a global strategy to address the pandemic threat [Medical Sciences]

30.12.2014 | Jamison Pike; Tiffany Bogich; Sarah Elwood; David C. Finnoff; Peter Daszak, Proceedings of the National Academy of Sciences current issue, 2014

Emerging pandemics threaten global health and economies and are increasing in frequency. Globally coordinated strategies to combat pandemics, similar to current strategies that address climate change, are largely adaptive, in that they attempt to reduce the impact of a pathogen after it has ...

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van der Waals interactions at the nanoscale: The effects of nonlocality [Applied Physical Sciences]

30.12.2014 | Yu Luo; Rongkuo Zhao; John B. Pendry, Proceedings of the National Academy of Sciences current issue, 2014

Calculated using classical electromagnetism, the van der Waals force increases without limit as two surfaces approach. In reality, the force saturates because the electrons cannot respond to fields of very short wavelength: polarization charges are always smeared out to some degree and in ...

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PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility [Developmental Biology]

30.12.2014 | Bingfang Xu; Angela M. Washington; Barry T. Hinton, Proceedings of the National Academy of Sciences current issue, 2014

Without a fully developed initial segment, the most proximal region of the epididymis, male infertility results. Therefore, it is important to understand the development and regulation of this crucial region. In addition to distinctively high activity levels of the components of the ERK pathway, ...

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Silencing urease: A key evolutionary step that facilitated the adaptation of Yersinia pestis to the flea-borne transmission route [Microbiology]

30.12.2014 | Iman Chouikha; B. Joseph Hinnebusch, Proceedings of the National Academy of Sciences current issue, 2014

The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral ...

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TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion [Medical Sciences]

30.12.2014 | Ryo Otomo; Chihiro Otsubo; Yuko Matsushima-Hibiya; Makoto Miyazaki; Fumio Tashiro; Hitoshi Ichikawa; Takashi Kohno; ..., Proceedings of the National Academy of Sciences current issue, 2014

Communication between cancer cells and their microenvironment controls cancer progression. Although the tumor suppressor p53 functions in a cell-autonomous manner, it has also recently been shown to function in a non–cell-autonomous fashion. Although functional defects have been reported in p53 ...

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Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis [Medical Sciences]

30.12.2014 | Thomas Gobbetti; Sina M. Coldewey; Jianmin Chen; Simon McArthur; Pauline le Faouder; Nicolas Cenac; Roderick J. Flow ..., Proceedings of the National Academy of Sciences current issue, 2014

Sepsis is characterized by overlapping phases of excessive inflammation temporally aligned with an immunosuppressed state, defining a complex clinical scenario that explains the lack of successful therapeutic options. Here we tested whether the formyl-peptide receptor 2/3 (Fpr2/3)—ortholog to ...

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Science and Culture: Q&A with Roger Malina [Science and Culture]

30.12.2014 | Maggie McKee, Proceedings of the National Academy of Sciences current issue, 2014

Professional astronomer Roger Malina is helping to lead a PhD program that marries art and science at the University of Texas at Dallas. Malina details the endeavor’s manifold challenges and his own artistic influences. Roger Malina. Image courtesy of the University of Texas at Dallas. Q: Many of ...

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Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase [Physiology]

30.12.2014 | Brian P. Johnson; Jacqueline A. Walisser; Yan Liu; Anna L. Shen; Erin L. McDearmon; Susan M. Moran; Brian E. McIntos ..., Proceedings of the National Academy of Sciences current issue, 2014

The diurnal variation in acetaminophen (APAP) hepatotoxicity (chronotoxicity) reportedly is driven by oscillations in metabolism that are influenced by the circadian phases of feeding and fasting. To determine the relative contributions of the central clock and the hepatocyte circadian clock in ...

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Auxin depletion from leaf primordia contributes to organ patterning [Plant Biology]

30.12.2014 | Jiyan Qi; Ying Wang; Ting Yu; Alexandre Cunha; Binbin Wu; Teva Vernoux; Elliot Meyerowitz; Yuling Jiao, Proceedings of the National Academy of Sciences current issue, 2014

Stem cells are responsible for organogenesis, but it is largely unknown whether and how information from stem cells acts to direct organ patterning after organ primordia are formed. It has long been proposed that the stem cells at the plant shoot apex produce a signal, which promotes leaf ...

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Mechanical resilience and cementitious processes in Imperial Roman architectural mortar [Engineering]

30.12.2014 | Marie D. Jackson; Eric N. Landis; Philip F. Brune; Massimo Vitti; Heng Chen; Qinfei Li; Martin Kunz; Hans-Rudolf Wen ..., Proceedings of the National Academy of Sciences current issue, 2014

The pyroclastic aggregate concrete of Trajan’s Markets (110 CE), now Museo Fori Imperiali in Rome, has absorbed energy from seismic ground shaking and long-term foundation settlement for nearly two millenia while remaining largely intact at the structural scale. The scientific basis of this ...

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