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19.066 Aktuelle Fachpublikationen in Science

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Wicked evolution: Can we address the sociobiological dilemma of pesticide resistance?

18.05.2018 | Fred Gould; Zachary S. Brown; Jennifer Kuzma, Science , 2018

Resistance to insecticides and herbicides has cost billions of U.S. dollars in the agricultural sector and could result in millions of lives lost to insect-vectored diseases. We mostly continue to use pesticides as if resistance is a temporary issue that will be addressed by commercialization of ...

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How to achieve a successful biaxial marriage

18.05.2018 | Philippe Poulin, Science , 2018

Matter is generally divided into three states, namely solid, liquid, and gas. Liquid crystals form a fourth state of matter; they combine properties of liquids, such as fluidity and the ability to flow, with properties of crystalline solids, such as structural order and specific optical and ...

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Hadza on the brink

18.05.2018 | Ann Gibbons, Science , 2018

Times are hard for the Hadza of Tanzania, who include some of the last people on the planet to live as nomadic hunter-gatherers. Their way of life has been a magnet for researchers for 60 years, and the subject of hundreds of scholarly papers, because it may offer the closest analog to the way ...

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Profiling transcription—a SLAM dunk

18.05.2018 | Caroline Ash; Paula A. Kiberstis, Science , 2018

Gene Regulation Identification of the direct target genes of transcription factors could shed light on how healthy cells become malignant. Muhar et al. applied a modified version of a transcript-mapping method called SLAM-seq to identify the target genes of two transcriptional regulators of major

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Fat, microRNAs, and liver disease

18.05.2018 | Caroline Ash; Leslie K. Ferrarelli, Science , 2018

Fatty Liver Disease Obesity and high-fat diets are linked to fatty liver disease. One hallmark of disease is repression of the cell-stress protein IRE1α. In livers from mice fed a high-fat diet and from patients with hepatic steatosis, Wang et al. found that IRE1α activity was repressed because of

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Hybrid molecular-colloidal liquid crystals

18.05.2018 | Haridas Mundoor; Sungoh Park; Bohdan Senyuk; Henricus H. Wensink; Ivan I. Smalyukh, Science , 2018

Order and fluidity often coexist, with examples ranging from biological membranes to liquid crystals, but the symmetry of these soft-matter systems is typically higher than that of the constituent building blocks. We dispersed micrometer-long inorganic colloidal rods in a nematic liquid ...

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Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease

18.05.2018 | Jihwan Park; Rojesh Shrestha; Chengxiang Qiu; Ayano Kondo; Shizheng Huang; Max Werth; Mingyao Li; Jonathan Barasch; ..., Science , 2018

Our understanding of kidney disease pathogenesis is limited by an incomplete molecular characterization of the cell types responsible for the organ’s multiple homeostatic functions. To help fill this knowledge gap, we characterized 57,979 cells from healthy mouse kidneys by using unbiased ...

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A selective autophagy receptor identified

18.05.2018 | Caroline Ash; Steve Mao, Science , 2018

Biochemistry Autophagosomes engulf and degrade cellular components in lysosomes. Degradation of ribosomes is called ribophagy and is an important source of nutrients. Using a recently reported method to isolate lysosomes, Wyant et al. profiled the dynamics of the lysosomal proteome under different

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Heating up suppresses appetite

18.05.2018 | Caroline Ash; Jesse Smith; Gemma Alderton, Science , 2018

Appetite Exercise can transiently suppress appetite, and it also makes you hot. Jeong et al. investigated whether loss of appetite is caused by increased body temperature. Hypothalamic neurons that express proopiomelanocortin control food intake. In mice, these neurons express a thermoreceptor

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Extraordinary plasticity of an inorganic semiconductor in darkness

18.05.2018 | Yu Oshima; Atsutomo Nakamura; Katsuyuki Matsunaga, Science , 2018

Inorganic semiconductors generally tend to fail in a brittle manner. Here, we report that extraordinary "plasticity" can take place in an inorganic semiconductor if the deformation is carried out "in complete darkness." Room-temperature deformation tests of zinc sulfide (ZnS) were performed under ...

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