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260 Aktuelle Fachpublikationen zum Thema Addition

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Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

05.12.2014 | Srinivasaraghavan Kannan; Anders Poulsen; Hai Yan Yang; Melvyn Ho; Shi Hua Ang; Tan Sum Wai Eldwin; Duraiswamy Athis ..., Biochemistry, 2014

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them ...

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A Synchrotron-Based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Prefibrillar Intermediates with Residue-Specific Resolution

03.12.2014 | Alexandra L. Klinger; Janna Kiselar; Serguei Ilchenko; Hiroaki Komatsu; Mark R. Chance; Paul H. Axelsen, Biochemistry, 2014

Structural models of the fibrils formed by the 40-residue amyloid-β (Aβ40) peptide in Alzheimer’s disease typically consist of linear polypeptide segments, oriented approximately perpendicular to the long axis of the fibril, and joined together as parallel in-register β-sheets to form filaments. ...

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Closure of the Cytoplasmic Gate Formed by TM5 and TM11 during Transport in the Oxalate/Formate Exchanger from Oxalobacter formigenes

02.12.2014 | Osigbemhe Iyalomhe; Dawn Z. Herrick; David S. Cafiso; Peter C. Maloney, Biochemistry, 2014

OxlT, the oxalate/formate exchanger of Oxalobacter formigenes, is a member of the major facilitator superfamily of transporters. In the present work, substrate (oxalate) was found to enhance the reactivity of the cysteine mutant S336C on the cytoplasmic end of helix 11 to methanethiosulfonate ...

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Mapping a Ketosynthase:Acyl Carrier Protein Binding Interface via Unnatural Amino Acid-Mediated Photo-Cross-Linking

26.11.2014 | Zhixia Ye; Gavin J. Williams, Biochemistry, 2014

Probing and interrogating protein interactions that involve acyl carrier proteins (ACP’s) in fatty acid synthases and polyketide synthases are critical to understanding the molecular basis for the programmed assembly of complex natural products. Here, we have used unnatural amino acid mutagenesis ...

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Light-Driven Na+ Pump from Gillisia limnaea: A High-Affinity Na+ Binding Site Is Formed Transiently in the Photocycle

24.11.2014 | Sergei P. Balashov; Eleonora S. Imasheva; Andrei K. Dioumaev; Jennifer M. Wang; Kwang-Hwan Jung; Janos K. Lanyi, Biochemistry, 2014

A group of microbial retinal proteins most closely related to the proton pump xanthorhodopsin has a novel sequence motif and a novel function. Instead of, or in addition to, proton transport, they perform light-driven sodium ion transport, as reported for one representative of this group (KR2) ...

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Component Interactions and Electron Transfer in Toluene/o-Xylene Monooxygenase

17.11.2014 | Alexandria Deliz Liang; Stephen J. Lippard, Biochemistry, 2014

The multicomponent protein toluene/o-xylene monooxygenase (ToMO) activates molecular oxygen to oxidize aromatic hydrocarbons. Prior to dioxygen activation, two electrons are injected into each of two diiron(III) units of the hydroxylase, a process that involves three redox active proteins: the ...

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BIN1 Membrane Curvature Sensing and Generation Show Autoinhibition Regulated by Downstream Ligands and PI(4,5)P2

14.11.2014 | Tingting Wu; Tobias Baumgart, Biochemistry, 2014

In striated muscles, invaginations from the plasma membrane, termed transverse tubules (T-tubule), function in the excitation–contraction coupling machinery. BIN1 (isoform8) plays a critical role in the biogenesis of T-tubules. BIN1 contains an N-terminal BAR domain to sense and induce membrane ...

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Acetylation of Gly1 and Lys2 Promotes Aggregation of Human γD-Crystallin

13.11.2014 | Michael A. DiMauro; Sandip K. Nandi; Cibin T. Raghavan; Rajiv Kumar Kar; Benlian Wang; Anirban Bhunia; Ram H. Nagara ..., Biochemistry, 2014

The human lens contains three major protein families: α-, β-, and γ-crystallin. Among the several variants of γ-crystallin in the human lens, γD-crystallin is a major form. γD-Crystallin is primarily present in the nuclear region of the lens and contains a single lysine residue at the second ...

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Formation of Highly Ordered Multimers in G-Quadruplexes

07.11.2014 | Petra Tóthová; Petra Krafčíková; Viktor Víglaský, Biochemistry, 2014

G-Rich DNA and RNA have a higher propensity to form G-quadruplex structures, but the presence of G-runs alone is not sufficient to prove that such sequences can form stable G-quadruplexes. While G-rich sequences are essential for G-quadruplex formation, not all G-rich sequences have the ...

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Mechanism of Amyloid-β Fibril Elongation

31.10.2014 | Thomas Gurry; Collin M. Stultz, Biochemistry, 2014

Amyloid-β is an intrinsically disordered protein that forms fibrils in the brains of patients with Alzheimer’s disease. To explore factors that affect the process of fibril growth, we computed the free energy associated with disordered amyloid-β monomers being added to growing amyloid fibrils ...

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