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Circadian Clock and Photoperiodic Response in Arabidopsis: From Seasonal Flowering to Redox Homeostasis

30.12.2014 | Jae Sung Shim; Takato Imaizumi, Biochemistry, 2014

Many of the developmental responses and behaviors in plants that occur throughout the year are controlled by photoperiod; among these, seasonal flowering is the most characterized. Molecular genetic and biochemical analyses have revealed the mechanisms by which plants sense changes in day length ...

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Cluster III of Low-Density Lipoprotein Receptor-Related Protein 1 Binds Activated Blood Coagulation Factor VIII

23.12.2014 | James H. Kurasawa; Svetlana A. Shestopal; Samuel A. Woodle; Mikhail V. Ovanesov; Timothy K. Lee; Andrey G. Sarafanov, Biochemistry, 2014

Low-density lipoprotein receptor-related protein 1 (LRP) mediates clearance of blood coagulation factor VIII (FVIII). In LRP, FVIII binds the complement-type repeats (CRs) of clusters II and IV, which also bind a majority of other LRP ligands. No ligand is known for LRP cluster I, and only three ...

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Characterizing Substrate Selectivity of Ubiquitin C-Terminal Hydrolase-L3 Using Engineered α-Linked Ubiquitin Substrates

17.12.2014 | Mario F. Navarro; Lisa Carmody; Octavio Romo-Fewell; Melissa E. Lokensgard; John J. Love, Biochemistry, 2014

The ubiquitin-proteasome system (UPS) is highly complex and entails the concerted actions of many enzymes that function to ubiquitinate proteins targeted to the proteasome as well as enzymes that remove and recycle ubiquitin for additional rounds of proteolysis. Ubiquitin C-terminal hydrolase-L3 ...

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Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

05.12.2014 | Srinivasaraghavan Kannan; Anders Poulsen; Hai Yan Yang; Melvyn Ho; Shi Hua Ang; Tan Sum Wai Eldwin; Duraiswamy Athis ..., Biochemistry, 2014

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them ...

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A Synchrotron-Based Hydroxyl Radical Footprinting Analysis of Amyloid Fibrils and Prefibrillar Intermediates with Residue-Specific Resolution

03.12.2014 | Alexandra L. Klinger; Janna Kiselar; Serguei Ilchenko; Hiroaki Komatsu; Mark R. Chance; Paul H. Axelsen, Biochemistry, 2014

Structural models of the fibrils formed by the 40-residue amyloid-β (Aβ40) peptide in Alzheimer’s disease typically consist of linear polypeptide segments, oriented approximately perpendicular to the long axis of the fibril, and joined together as parallel in-register β-sheets to form filaments. ...

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Closure of the Cytoplasmic Gate Formed by TM5 and TM11 during Transport in the Oxalate/Formate Exchanger from Oxalobacter formigenes

02.12.2014 | Osigbemhe Iyalomhe; Dawn Z. Herrick; David S. Cafiso; Peter C. Maloney, Biochemistry, 2014

OxlT, the oxalate/formate exchanger of Oxalobacter formigenes, is a member of the major facilitator superfamily of transporters. In the present work, substrate (oxalate) was found to enhance the reactivity of the cysteine mutant S336C on the cytoplasmic end of helix 11 to methanethiosulfonate ...

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Mapping a Ketosynthase:Acyl Carrier Protein Binding Interface via Unnatural Amino Acid-Mediated Photo-Cross-Linking

26.11.2014 | Zhixia Ye; Gavin J. Williams, Biochemistry, 2014

Probing and interrogating protein interactions that involve acyl carrier proteins (ACP’s) in fatty acid synthases and polyketide synthases are critical to understanding the molecular basis for the programmed assembly of complex natural products. Here, we have used unnatural amino acid mutagenesis ...

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Light-Driven Na+ Pump from Gillisia limnaea: A High-Affinity Na+ Binding Site Is Formed Transiently in the Photocycle

24.11.2014 | Sergei P. Balashov; Eleonora S. Imasheva; Andrei K. Dioumaev; Jennifer M. Wang; Kwang-Hwan Jung; Janos K. Lanyi, Biochemistry, 2014

A group of microbial retinal proteins most closely related to the proton pump xanthorhodopsin has a novel sequence motif and a novel function. Instead of, or in addition to, proton transport, they perform light-driven sodium ion transport, as reported for one representative of this group (KR2) ...

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Component Interactions and Electron Transfer in Toluene/o-Xylene Monooxygenase

17.11.2014 | Alexandria Deliz Liang; Stephen J. Lippard, Biochemistry, 2014

The multicomponent protein toluene/o-xylene monooxygenase (ToMO) activates molecular oxygen to oxidize aromatic hydrocarbons. Prior to dioxygen activation, two electrons are injected into each of two diiron(III) units of the hydroxylase, a process that involves three redox active proteins: the ...

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BIN1 Membrane Curvature Sensing and Generation Show Autoinhibition Regulated by Downstream Ligands and PI(4,5)P2

14.11.2014 | Tingting Wu; Tobias Baumgart, Biochemistry, 2014

In striated muscles, invaginations from the plasma membrane, termed transverse tubules (T-tubule), function in the excitation–contraction coupling machinery. BIN1 (isoform8) plays a critical role in the biogenesis of T-tubules. BIN1 contains an N-terminal BAR domain to sense and induce membrane ...

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