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321 Aktuelle Fachpublikationen zum Thema Addition

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Crystal Structure of an Engineered LRRTM2 Synaptic Adhesion Molecule and a Model for Neurexin Binding

03.02.2016 | Anja Paatero; Katja Rosti; Alexander V. Shkumatov; Celeste Sele; Cecilia Brunello; Kai Kysenius; Prosanta Singha; Vi ..., Biochemistry, 2016

Synaptic adhesion molecules are key components in development of the brain, and in the formation of neuronal circuits, as they are central in the assembly and maturation of chemical synapses. Several families of neuronal adhesion molecules have been identified such as the neuronal cell adhesion ...

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Role of the Proximal Cysteine Hydrogen Bonding Interaction in Cytochrome P450 2B4 Studied by Cryoreduction, Electron Paramagnetic Resonance, and Electron–Nuclear Double Resonance Spectroscopy

03.02.2016 | Roman Davydov; Sangchoul Im; Muralidharan Shanmugam; William A. Gunderson; Naw May Pearl; Brian M. Hoffman; Lucy Waskell, Biochemistry, 2016

Crystallographic studies have shown that the F429H mutation of cytochrome P450 2B4 introduces an H-bond between His429 and the proximal thiolate ligand, Cys436, without altering the protein fold but sharply decreases the enzymatic activity and stabilizes the oxyferrous P450 2B4 complex. To ...

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Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors

01.02.2016 | Takashi Masaoka; Haiyan Zhao; Danielle R. Hirsch; Michael P. D’Erasmo; Christine Meck; Brittany Varnado; Ankit Gupta ..., Biochemistry, 2016

The natural product α-hydroxytropolones manicol and β-thujaplicinol inhibit replication of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2, respectively) at nontoxic concentrations. Because these were originally developed as divalent metal-sequestering inhibitors of the ribonuclease H activity of ...

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Role of Histone-Modifying Enzymes and Their Complexes in Regulation of Chromatin Biology

26.01.2016 | Renee DesJarlais; Peter J. Tummino, Biochemistry, 2016

In 1964, Alfrey and colleagues proposed that acetylation and methylation of histones may regulate RNA synthesis and described “the possibility that relatively minor modifications of histone structure, taking place on the intact protein molecule, offer a means of switching-on or off RNA synthesis ...

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Identification of C1q as a Binding Protein for Advanced Glycation End Products

13.01.2016 | Miho Chikazawa; Takahiro Shibata; Yukinori Hatasa; Sayumi Hirose; Natsuki Otaki; Fumie Nakashima; Mika Ito; Sachiko ..., Biochemistry, 2016

Advanced glycation end products (AGEs) make up a heterogeneous group of molecules formed from the nonenzymatic reaction of reducing sugars with the free amino groups of proteins. The abundance of AGEs in a variety of age-related diseases, including diabetic complications and atherosclerosis, and ...

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Structural and Biochemical Characterizations of Methanoredoxin from Methanosarcina acetivorans, a Glutaredoxin-Like Enzyme with Coenzyme M-Dependent Protein Disulfide Reductase Activity

30.12.2015 | Deepa Yenugudhati; Divya Prakash; Adepu K. Kumar; R. Siva Sai Kumar; Neela H. Yennawar; Hemant P. Yennawar; James G. ..., Biochemistry, 2015

Glutaredoxins (GRXs) are thiol–disulfide oxidoreductases abundant in prokaryotes, although little is understood of these enzymes from the domain Archaea. The numerous characterized GRXs from the domain Bacteria utilize a diversity of low-molecular-weight thiols in addition to glutathione as ...

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Protein Methyltransferases: A Distinct, Diverse, and Dynamic Family of Enzymes

22.12.2015 | P. Ann Boriack-Sjodin; Kerren K. Swinger, Biochemistry, 2015

Methyltransferase proteins make up a superfamily of enzymes that add one or more methyl groups to substrates that include protein, DNA, RNA, and small molecules. The subset of proteins that act upon arginine and lysine side chains are characterized as epigenetic targets because of their activity ...

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Structural Basis for Dimerization and DNA Binding of Transcription Factor FLI1

10.12.2015 | Caixia Hou; Oleg V. Tsodikov, Biochemistry, 2015

FLI1 (Friend leukemia integration 1) is a metazoan transcription factor that is upregulated in a number of cancers. In addition, rearrangements of the fli1 gene cause sarcomas, leukemias, and lymphomas. These rearrangements encode oncogenic transcription factors, in which the DNA binding domain ...

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Neuropathy Target Esterase Is Degraded by the Ubiquitin–Proteasome Pathway with ARA54 as the Ubiquitin Ligase

10.12.2015 | Ding-Xin Long; Pan Wang; Ying-Jian Sun; Rui Chen; Yi-Jun Wu, Biochemistry, 2015

Neuropathy target esterase (NTE) is an endoplasmic reticulum membrane-associated phospholipase B, which is essential for embryonic and nervous system development. However, the regulation of NTE at the protein level had not been thoroughly investigated. Our previous study showed that NTE was ...

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Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region

10.12.2015 | Guillaume Desrochers; Mathieu Lussier-Price; James G. Omichinski; Annie Angers, Biochemistry, 2015

Itch is a member of the C2-WW-HECT (CWH) family of ubiquitin ligases involved in the control of inflammatory signaling pathways, several transcription factors, and sorting of surface receptors to the degradative pathway. In addition to these common domains, Itch also contains a conserved ...

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