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255 Aktuelle Fachpublikationen zum Thema Addition

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Component Interactions and Electron Transfer in Toluene/o-Xylene Monooxygenase

17.11.2014 | Alexandria Deliz Liang; Stephen J. Lippard, Biochemistry, 2014

The multicomponent protein toluene/o-xylene monooxygenase (ToMO) activates molecular oxygen to oxidize aromatic hydrocarbons. Prior to dioxygen activation, two electrons are injected into each of two diiron(III) units of the hydroxylase, a process that involves three redox active proteins: the ...


BIN1 Membrane Curvature Sensing and Generation Show Autoinhibition Regulated by Downstream Ligands and PI(4,5)P2

14.11.2014 | Tingting Wu; Tobias Baumgart, Biochemistry, 2014

In striated muscles, invaginations from the plasma membrane, termed transverse tubules (T-tubule), function in the excitation–contraction coupling machinery. BIN1 (isoform8) plays a critical role in the biogenesis of T-tubules. BIN1 contains an N-terminal BAR domain to sense and induce membrane ...


Acetylation of Gly1 and Lys2 Promotes Aggregation of Human γD-Crystallin

13.11.2014 | Michael A. DiMauro; Sandip K. Nandi; Cibin T. Raghavan; Rajiv Kumar Kar; Benlian Wang; Anirban Bhunia; Ram H. Nagara ..., Biochemistry, 2014

The human lens contains three major protein families: α-, β-, and γ-crystallin. Among the several variants of γ-crystallin in the human lens, γD-crystallin is a major form. γD-Crystallin is primarily present in the nuclear region of the lens and contains a single lysine residue at the second ...


Formation of Highly Ordered Multimers in G-Quadruplexes

07.11.2014 | Petra Tóthová; Petra Krafčíková; Viktor Víglaský, Biochemistry, 2014

G-Rich DNA and RNA have a higher propensity to form G-quadruplex structures, but the presence of G-runs alone is not sufficient to prove that such sequences can form stable G-quadruplexes. While G-rich sequences are essential for G-quadruplex formation, not all G-rich sequences have the ...


Mechanism of Amyloid-β Fibril Elongation

31.10.2014 | Thomas Gurry; Collin M. Stultz, Biochemistry, 2014

Amyloid-β is an intrinsically disordered protein that forms fibrils in the brains of patients with Alzheimer’s disease. To explore factors that affect the process of fibril growth, we computed the free energy associated with disordered amyloid-β monomers being added to growing amyloid fibrils ...


Quantification of Quaternary Structure Stability in Aggregation-Prone Proteins under Physiological Conditions: The Transthyretin Case

07.10.2014 | Lei Z. Robinson; Natàlia Reixach, Biochemistry, 2014

The quaternary structure stability of proteins is typically studied under conditions that accelerate their aggregation/unfolding processes on convenient laboratory time scales. Such conditions include high temperature or pressure, chaotrope-mediated unfolding, or low or high pH. These approaches ...


Crystal Structure of Psb31, a Novel Extrinsic Protein of Photosystem II from a Marine Centric Diatom and Implications for Its Binding and Function

11.09.2013 | Ryo Nagao; Michihiro Suga; Ayako Niikura; Akinori Okumura; Faisal Hammad Mekky Koua; Takehiro Suzuki; Tatsuya Tomo; ..., Biochemistry, 2013

Psb31 is a fifth extrinsic protein found in photosystem II (PSII) of a centric diatom, Chaetoceros gracilis. The protein has been shown to bind directly to PSII in the absence of other extrinsic proteins and serves in part as a substitute for PsbO in supporting oxygen evolution. We report here ...


Localized Permeabilization of E. coli Membranes by the Antimicrobial Peptide Cecropin A

10.09.2013 | Nambirajan Rangarajan; Somenath Bakshi; James C. Weisshaar, Biochemistry, 2013

Fluorescence microscopy enables detailed observation of the effects of the antimicrobial peptide Cecropin A on the outer membrane (OM) and cytoplasmic membrane (CM) of single E. coli cells with subsecond time resolution. Fluorescence from periplasmic GFP decays and cell growth halts when the OM ...


Binding of Chondroitin 4-Sulfate to Cathepsin S Regulates Its Enzymatic Activity

04.09.2013 | Juliette Sage; Florian Mallèvre; Fabien Barbarin-Costes; Sergey A. Samsonov; Jan-Philip Gehrcke; Maria Teresa Pisaba ..., Biochemistry, 2013

Human cysteine cathepsin S (catS) participates in distinct physiological and pathophysiological cellular processes and is considered as a valuable therapeutic target in autoimmune diseases, cancer, atherosclerosis, and asthma. We evaluated the capacity of negatively charged glycosaminoglycans ...


Contribution of Electrostatics to the Binding of Pancreatic-Type Ribonucleases to Membranes

30.08.2013 | Nadia K. Sundlass; Chelcie H. Eller; Qiang Cui; Ronald T. Raines, Biochemistry, 2013

Pancreatic-type ribonucleases show clinical promise as chemotherapeutic agents but are limited in efficacy by the inefficiency of their uptake by human cells. Cellular uptake can be increased by the addition of positive charges to the surface of ribonucleases, either by site-directed mutagenesis ...


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