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302 Aktuelle Fachpublikationen zum Thema Addition

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Species-Specific Structural and Functional Divergence of α-Crystallins: Zebrafish αBa- and Rodent αAins-Crystallin Encode Activated Chaperones

17.09.2015 | Hanane A. Koteiche; Derek P. Claxton; Sanjay Mishra; Richard A. Stein; Ezelle T. McDonald; Hassane S. Mchaourab, Biochemistry, 2015

In addition to contributing to lens optical properties, the α-crystallins are small heat shock proteins that possess chaperone activity and are predicted to bind and sequester destabilized proteins to delay cataract formation. The current model of α-crystallin chaperone mechanism envisions a ...


Slowed Diffusion and Excluded Volume Both Contribute to the Effects of Macromolecular Crowding on Alcohol Dehydrogenase Steady-State Kinetics

16.09.2015 | Samuel H. Schneider; Schuyler P. Lockwood; Dominique I. Hargreaves; David J. Slade; Micaela A. LoConte; Bridget E. L ..., Biochemistry, 2015

To understand the consequences of macromolecular crowding, studies have largely employed in vitro experiments with synthetic polymers assumed to be both pure and “inert”. These polymers alter enzyme kinetics by excluding volume that would otherwise be available to the enzymes, substrates, and ...


Identification of Amino Acids at the Catalytic Site of a Ferredoxin-Dependent Cyanobacterial Nitrate Reductase

04.09.2015 | Anurag P. Srivastava; James P. Allen; Brian J. Vaccaro; Masakazu Hirasawa; Suzanne Alkul; Michael K. Johnson; David ..., Biochemistry, 2015

An in silico model of the ferredoxin-dependent nitrate reductase from the cyanobacterium Synechococcus sp. PCC 7942, and information about active sites in related enzymes, had identified Cys148, Met149, Met306, Asp163, and Arg351 as amino acids likely to be involved in either nitrate binding, ...


Early Events in the Amyloid Formation of the A546T Mutant of Transforming Growth Factor β-Induced Protein in Corneal Dystrophies Compared to the Nonfibrillating R555W and R555Q Mutants

02.09.2015 | Heidi Koldsø; Ole Juul Andersen; Camilla Lund Nikolajsen; Carsten Scavenius; Charlotte S. Sørensen; Jarl Underhaug; ..., Biochemistry, 2015

The human transforming growth factor β-induced protein (TGFBIp) is involved in several types of corneal dystrophies where protein aggregation and amyloid fibril formation severely impair vision. Most disease-causing mutations are located in the last of four homologous fasciclin-1 (FAS1) domains ...


The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities

28.08.2015 | Carlo Guardiani; Mariano Andrea Scorciapino; Giuseppe Federico Amodeo; Joze Grdadolnik; Giuseppe Pappalardo; Vito De ..., Biochemistry, 2015

The voltage-dependent anion channel (VDAC) is the main mitochondrial porin allowing the exchange of ions and metabolites between the cytosol and the mitochondrion. In addition, VDAC was found to actively interact with proteins playing a fundamental role in the regulation of apoptosis and being of ...


Concerted Protein and Nucleic Acid Conformational Changes Observed Prior to Nucleotide Incorporation in a Bacterial RNA Polymerase: Raman Crystallographic Evidence

18.08.2015 | Ioanna H. Antonopoulos; Brittany A. Warner; Paul R. Carey, Biochemistry, 2015

Transcription elongation requires the continuous incorporation of ribonucleotide triphosphates into a growing transcript. RNA polymerases (RNAPs) are able to processively synthesize a growing RNA chain via translocation of the RNAP enzyme along its nucleic acid template strand after each ...


Role of GxxxG Motifs in Transmembrane Domain Interactions

13.08.2015 | Mark G. Teese; Dieter Langosch, Biochemistry, 2015

Transmembrane (TM) helices of integral membrane proteins can facilitate strong and specific noncovalent protein–protein interactions. Mutagenesis and structural analyses have revealed numerous examples in which the interaction between TM helices of single-pass membrane proteins is dependent on a ...


Metal Stabilization of Collagen and de Novo Designed Mimetic Peptides

10.08.2015 | Avanish S. Parmar; Fei Xu; Douglas H. Pike; Sandeep V. Belure; Nida F. Hasan; Kathryn E. Drzewiecki; David I. Shreib ..., Biochemistry, 2015

We explore the design of metal binding sites to modulate triple-helix stability of collagen and collagen-mimetic peptides. Globular proteins commonly utilize metals to connect tertiary structural elements that are well separated in sequence, constraining structure and enhancing stability. It is ...


Development of a Reagentless Biosensor for Inorganic Phosphate, Applicable over a Wide Concentration Range

04.08.2015 | Claudia Solscheid; Simone Kunzelmann; Colin T. Davis; Jackie L. Hunter; Annie Nofer; Martin R. Webb, Biochemistry, 2015

A fluorescent reagentless biosensor for inorganic phosphate (Pi), based on the E. coli PstS phosphate binding protein, was redesigned to allow measurements of higher Pi concentrations and at low, substoichiometric concentrations of biosensor. This was achieved by weakening Pi binding of the ...


Importance of β2–β3 Loop Motion for the Increased Binding and Decreased Selectivity of the ΔLL Mutant of the Human Papillomavirus Type 6 E2 Protein

30.07.2015 | Geoffrey M. Gray; Arjan van der Vaart, Biochemistry, 2015

The binding affinity of the human papillomavirus type 6 E2 protein is strongly mediated by the sequence of the DNA linker region, with high affinity for the AATT linker and low affinity for the CCGG linker. When two terminal leucine residues are removed from the protein, the level of binding to ...


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