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The ssrA-Tag Facilitated Degradation of an Integral Membrane Protein

18.04.2016 | Qian Chai; Zhaoshuai Wang; Stacy R. Webb; Rebecca E. Dutch; Yinan Wei, Biochemistry, 2016

ATP-dependent degradation plays a critical role in the quality control and recycling of proteins in cells. However, complete degradation of membrane proteins by ATP-dependent proteases in bacteria is not well-studied. We discovered that the degradation of a multidomain and multispan integral ...


The Molybdenum Active Site of Formate Dehydrogenase Is Capable of Catalyzing C–H Bond Cleavage and Oxygen Atom Transfer Reactions

18.04.2016 | Tobias Hartmann; Peer Schrapers; Tillmann Utesch; Manfred Nimtz; Yvonne Rippers; Holger Dau; Maria Andrea Mroginski; ..., Biochemistry, 2016

Formate dehydrogenases (FDHs) are capable of performing the reversible oxidation of formate and are enzymes of great interest for fuel cell applications and for the production of reduced carbon compounds as energy sources from CO2. Metal-containing FDHs in general contain a highly conserved ...


Substrate Binding Mode and Molecular Basis of a Specificity Switch in Oxalate Decarboxylase

04.04.2016 | Wen Zhu; Lindsey M. Easthon; Laurie A. Reinhardt; Chingkuang Tu; Steven E. Cohen; David N. Silverman; Karen N. Allen ..., Biochemistry, 2016

Oxalate decarboxylase (OxDC) catalyzes the conversion of oxalate into formate and carbon dioxide in a remarkable reaction that requires manganese and dioxygen. Previous studies have shown that replacing an active-site loop segment Ser161-Glu162-Asn163-Ser164 in the N-terminal domain of OxDC with ...


Membrane-Anchored Cyclic Peptides as Effectors of Mitochondrial Oxidative Phosphorylation

29.03.2016 | Kristin Shirey; Kayla R. Stover; John Cleary; Ngoc Hoang; Jonathan Hosler, Biochemistry, 2016

The echinocandins are membrane-anchored, cyclic lipopeptides (CLPs) with antifungal activity due to their ability to inhibit a glucan synthase located in the plasma membrane of fungi such as Candida albicans. A hydrophobic tail of an echinocandin CLP inserts into a membrane, placing a six-amino ...


Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding

16.03.2016 | Andrea C. McReynolds; Aroon S. Karra; Yan Li; Elias Daniel Lopez; Adrian G. Turjanski; Elhadji Dioum; Kristina Loren ..., Biochemistry, 2016

The mitogen-activated protein kinase ERK2 is able to elicit a wide range of context-specific responses to distinct stimuli, but the mechanisms underlying this versatility remain in question. Some cellular functions of ERK2 are mediated through regulation of gene expression. In addition to ...


Role of Electrostatic Interactions in Binding of Peptides and Intrinsically Disordered Proteins to Their Folded Targets: 2. The Model of Encounter Complex Involving the Double Mutant of the c-Crk N-SH3 Domain and Peptide Sos

14.03.2016 | Tairan Yuwen; Yi Xue; Nikolai R. Skrynnikov, Biochemistry, 2016

In the first part of this work (paper 1, Xue, Y. et al. Biochemistry 2014, 53, 6473), we have studied the complex between the 10-residue peptide Sos and N-terminal SH3 domain from adaptor protein c-Crk. In the second part (this paper), we designed the double mutant of the c-Crk N-SH3 domain, ...


Energetic Coupling between Ligand Binding and Dimerization in Escherichia coli Phosphoglycerate Mutase

10.03.2016 | Nathan W. Gardner; Lyman K. Monroe; Daisuke Kihara; Chiwook Park, Biochemistry, 2016

Energetic coupling of two molecular events in a protein molecule is ubiquitous in biochemical reactions mediated by proteins, such as catalysis and signal transduction. Here, we investigate energetic coupling between ligand binding and folding of a dimer using a model system that shows ...


Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases

10.03.2016 | Xuan Zhang; Bekir E. Eser; Prem K. Chanani; Tadhg P. Begley; Steven E. Ealick, Biochemistry, 2016

Thiamin diphosphate is an essential cofactor in all forms of life and plays a key role in amino acid and carbohydrate metabolism. Its biosynthesis involves separate syntheses of the pyrimidine and thiazole moieties, which are then coupled to form thiamin monophosphate. A final phosphorylation ...


Entrapment of Water at the Transmembrane Helix–Helix Interface of Quiescin Sulfhydryl Oxidase 2

22.02.2016 | Christian L. Ried; Christina Scharnagl; Dieter Langosch, Biochemistry, 2016

Little is known about how a membrane can regulate interactions between transmembrane helices. Here, we show that strong self-interaction of the transmembrane helix of human quiescin sulfhydryl oxidase 2 rests on a motif of conserved amino acids comprising one face of the helix. Atomistic ...


Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry

19.02.2016 | Michael J. Lucido; Benjamin J. Orlando; Alex J. Vecchio; Michael G. Malkowski, Biochemistry, 2016

Aspirin and other nonsteroidal anti-inflammatory drugs target the cyclooxygenase enzymes (COX-1 and COX-2) to block the formation of prostaglandins. Aspirin is unique in that it covalently modifies each enzyme by acetylating Ser-530 within the cyclooxygenase active site. Acetylation of COX-1 ...


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