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2.797 Aktuelle Fachpublikationen zum Thema Software

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Self-Organizing Map (SOM) and Support Vector Machine (SVM) Models for the Prediction of Human Epidermal Growth Factor Receptor (EGFR/ ErbB-1) Inhibitors

24.05.2016 | Kong, Yue; Qu, Dan; Chen, Xiaoyan; Gong, Ya-Nan; Yan, Aixia, Combinatorial Chemistry, 2016

Abstract: EGFR (ErbB-1/HER1) kinase plays an important role in cancer therapy. Two classification models were established to predict whether a compound is an inhibitor or a decoy of human EGFR (ErbR-1) by using Kohonen’s self-organizing map (SOM) and support vector machine (SVM). A ...

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Serial block face scanning electron microscopy and the reconstruction of plant cell membrane systems

20.05.2016 | M. KITTELMANN, C. HAWES, L. HUGHES, Journal of Microscopy, 2016

Summary Serial block face imaging with the scanning electron microscope has been developed as an alternative to serial sectioning and transmission electron microscopy for the ultrastructural analysis of the three‐dimensional organization of cells and tissues. An ultramicrotome within the ...

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[In Depth] ‘Cell painting’ highlights responses to drugs and toxins

20.05.2016 | Elizabeth Pennisi, Science , 2016

Just as a careful watcher can gauge the emotional state of a person by noticing a blush or other visual cues, scientists are becoming adept at discerning the state of a cell with the help of molecular "paints" that highlight more than a thousand cellular features together. By using computerized ...

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IJMS, Vol. 17, Pages 752: How Diet Intervention via Modulation of DNA Damage Response through MicroRNAs May Have an Effect on Cancer Prevention and Aging, an in Silico Study

19.05.2016 | Carotenuto, Felicia ; Albertini, Maria C.; Coletti, Dario ; Vilmercati, Alessandra ; Campanella, Luigi ; Darzynkiewi ..., International Journal of Molecular Sciences, 2016

The DNA damage response (DDR) is a molecular mechanism that cells have evolved to sense DNA damage (DD) to promote DNA repair, or to lead to apoptosis, or cellular senescence if the damage is too extensive. Recent evidence indicates that microRNAs (miRs) play a critical role in the regulation of ...

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Robust dipstick urinalysis using a low-cost, micro-volume slipping manifold and mobile phone platform

19.05.2016 | Gennifer T. Smith; Nicholas Dwork; Saara A. Khan; Matthew Millet; Kiran Magar; Mehdi Javanmard; Audrey K. Ellerbee B ..., Lab on a Chip, 2016

We introduce a novel manifold and companion software for dipstick urinalysis that eliminate many of the aspects that are traditionally plagued by user error: precise sample delivery, accurate readout timing, and controlled lighting conditions. The proposed all-acrylic slipping manifold is ...

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Numerical moisture simulation of redeveloped structures using active materials based on cement composite

18.05.2016 | A. Břenek, V. Václavík, T. Dvorský, V. Šimíček, J. Valíček, M. Kušnerová, M. Harničárová, Materialwissenschaft und Werkstofftechnik, 2016

Signs of moisture in the connecting joints of window constructions represent a typical feature of contemporary modern civil engineering. These problems occur both in new buildings and in reconstructed historical buildings. They manifest themselves as wet spots or black mould on window reveals, ...

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Energies, Vol. 9, Pages 377: A Novel Single Winding Structure and Closed Loop Control of the Suspension Force Vector of Bearingless Permanent Magnet Synchronous Motors

18.05.2016 | Zhu, Huangqiu ; Yuan, Jianfei ; Jv, Jintao, Energies, 2016

At present, because of their advantages of simple structure, low cost, low power consumption and high efficiency, single winding bearingless permanent magnet synchronous motors (SBPMSMs) have become one of the research hotspots in the bearingless technology field. However, a high ...

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Optimization of Analytical Potentials for Coarse-Grained Biopolymer Models

18.05.2016 | Paolo Mereghetti; Giuseppe Maccari; Giulia Lia Beatrice Spampinato; Valentina Tozzini, Journal of Physical Chemistry B, 2016

The increasing trend in the recent literature on coarse grained (CG) models testifies their impact in the study of complex systems. However, the CG model landscape is variegated: even considering a given resolution level, the force fields are very heterogeneous and optimized with very different ...

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Bremsstrahlung enhancement in electron probe microanalysis for homogeneous samples using Monte Carlo simulation

17.05.2016 | M. PETACCIA, S. SEGUI, G. CASTELLANO, Journal of Microscopy, 2016

Summary Fluorescence enhancement in samples irradiated in a scanning electron microscope or an electron microprobe should be appropriately assessed in order not to distort quantitative analyses. Several models have been proposed to take into account this effect and current quantification ...

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Development of an ultra high performance liquid chromatography method for determining triamcinolone acetonide in hydrogels using the design of experiments/design space strategy in combination with process capability index

17.05.2016 | Alexis Oliva, Cecilia Monzón, Ana Santoveña, José B. Fariña, Matías Llabrés, Journal of Separation Science, 2016

An ultra high performance liquid chromatography method was developed and validated for the quantitation of triamcinolone acetonide in an injectable ophthalmic hydrogel to determine the contribution of analytical method error in the content uniformity measurement. During the development phase, ...

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