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308 Aktuelle Fachpublikationen zum Thema temperature

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Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients [Biophysics and Computational Biology]

09.12.2014 | Conan K. Wang; Susan E. Northfield; Barbara Colless; Stephanie Chaousis; Ingrid Hamernig; Rink-Jan Lohman; Daniel S. ..., Proceedings of the National Academy of Sciences current issue, 2014

Enhancing the oral bioavailability of peptide drug leads is a major challenge in drug design. As such, methods to address this challenge are highly sought after by the pharmaceutical industry. Here, we propose a strategy to identify appropriate amides for N-methylation using temperature ...

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Force distribution affects vibrational properties in hard-sphere glasses [Physics]

02.12.2014 | Eric DeGiuli; Edan Lerner; Carolina Brito; Matthieu Wyart, Proceedings of the National Academy of Sciences current issue, 2014

We theoretically and numerically study the elastic properties of hard-sphere glasses and provide a real-space description of their mechanical stability. In contrast to repulsive particles at zero temperature, we argue that the presence of certain pairs of particles interacting with a small force ...

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Charging-free electrochemical system for harvesting low-grade thermal energy [Applied Physical Sciences]

02.12.2014 | Yuan Yang; Seok Woo Lee; Hadi Ghasemi; James Loomis; Xiaobo Li; Daniel Kraemer; Guangyuan Zheng; Yi Cui; Gang Chen, Proceedings of the National Academy of Sciences current issue, 2014

Efficient and low-cost systems are needed to harvest the tremendous amount of energy stored in low-grade heat sources ...

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Effects of temperature and precipitation variability on the risk of violence in sub-Saharan Africa, 1980-2012 [Social Sciences]

25.11.2014 | John O’Loughlin; Andrew M. Linke; Frank D. W. Witmer, Proceedings of the National Academy of Sciences current issue, 2014

Ongoing debates in the academic community and in the public policy arena continue without clear resolution about the significance of global climate change for the risk of increased conflict. Sub-Saharan Africa is generally agreed to be the region most vulnerable to such climate impacts. Using a ...

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Ocean surface temperature variability: Large model-data differences at decadal and longer periods [Earth, Atmospheric, and Planetary Sciences]

25.11.2014 | Thomas Laepple; Peter Huybers, Proceedings of the National Academy of Sciences current issue, 2014

The variability of sea surface temperatures (SSTs) at multidecadal and longer timescales is poorly constrained, primarily because instrumental records are short and proxy records are noisy. Through applying a new noise filtering technique to a global network of late Holocene SST proxies, we ...

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Recent climate and air pollution impacts on Indian agriculture [Sustainability Science]

18.11.2014 | Jennifer Burney; V. Ramanathan, Proceedings of the National Academy of Sciences current issue, 2014

Recent research on the agricultural impacts of climate change has primarily focused on the roles of temperature and precipitation. These studies show that India has already been negatively affected by recent climate trends. However, anthropogenic climate changes are a result of both global ...

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Cerebral small vessel disease-related protease HtrA1 processes latent TGF-{beta} binding protein 1 and facilitates TGF-{beta} signaling [Medical Sciences]

18.11.2014 | Nathalie Beaufort; Eva Scharrer; Elisabeth Kremmer; Vanda Lux; Michael Ehrmann; Robert Huber; Henry Houlden; David W ..., Proceedings of the National Academy of Sciences current issue, 2014

High temperature requirement protein A1 (HtrA1) is a primarily secreted serine protease involved in a variety of cellular processes including transforming growth factor β (TGF-β) signaling. Loss of its activity causes cerebral autosomal recessive arteriopathy with subcortical infarcts and ...

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Days to heading 7, a major quantitative locus determining photoperiod sensitivity and regional adaptation in rice [Agricultural Sciences]

18.11.2014 | He Gao; Mingna Jin; Xiao-Ming Zheng; Jun Chen; Dingyang Yuan; Yeyun Xin; Maoqing Wang; Dongyi Huang; Zhe Zhang; Kunn ..., Proceedings of the National Academy of Sciences current issue, 2014

Success of modern agriculture relies heavily on breeding of crops with maximal regional adaptability and yield potentials. A major limiting factor for crop cultivation is their flowering time, which is strongly regulated by day length (photoperiod) and temperature. Here we report identification ...

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Part-crystalline part-liquid state and rattling-like thermal damping in materials with chemical-bond hierarchy [Physics]

21.10.2014 | Wujie Qiu; Lili Xi; Ping Wei; Xuezhi Ke; Jihui Yang; Wenqing Zhang, Proceedings of the National Academy of Sciences current issue, 2014

Understanding thermal and phonon transport in solids has been of great importance in many disciplines such as thermoelectric materials, which usually requires an extremely low lattice thermal conductivity (LTC). By analyzing the finite-temperature structural and vibrational characteristics of ...

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Caenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations [Genetics]

14.10.2014 | Aisa Sakaguchi; Peter Sarkies; Matt Simon; Anna-Lisa Doebley; Leonard D. Goldstein; Ashley Hedges; Kohta Ikegami; St ..., Proceedings of the National Academy of Sciences current issue, 2014

Germ cells are maintained in a pristine non-aging state as they proliferate over generations. Here, we show that a novel function of the Caenorhabditis elegans RNA interference proteins RNAi spreading defective (RSD)-2 and RSD-6 is to promote germ cell immortality at high temperature. rsd mutants ...

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