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Stereoselective Accumulation of Propranolol Enantiomers in K562 and K562/ADR Cells

09.05.2013 | Xiao‐Li Zheng, Qin‐Qin Yu, Yi Wang, Su Zeng, Chirality, 2013

ABSTRACT The stereoselective uptake of propranolol enantiomers was investigated by using the K562 and K562 adriamycin‐resistant cell line (K562/ADR) as a model. An enantioselective RP‐HPLC method was applied to determine the accumulation of propranolol (PPL) stereoisomers in K562 and ...

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Clinoptilolite particles as a carrier for biocatalysts immobilization: invertase immobilization and characterization

09.05.2013 | Tahsin Bahar, Asia-Pacific Journal of Chemical Engineering, 2013

ABSTRACT Clinoptilolite, a natural zeolite, was proposed as a carrier for immobilized biocatalyst systems by polyethyleneimine and glutaraldehyde activation. Invertase (EC 3.2.1.26, beta‐fructofuranosidase) as a model biocatalyst was covalently attached onto the particles by direct ...

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A Validated Normal Phase LC Method for Enantiomeric Separation of Rasagiline Mesylate and Its (S)‐Enantiomer on Cellulose Derivative‐Based Chiral Stationary Phase

09.05.2013 | P. Sunil Reddy, K. Sudhakar Babu, Navneet Kumar, Chirality, 2013

ABSTRACT A simple, sensitive, and robust normal‐phase isocratic HPLC‐UV method was developed and validated for the enantiomeric separation of rasagiline mesylate and its (S)‐enantiomer. The rasagiline and its (S)‐enantiomer were resolved on a Chiralcel‐OJ‐H (4‐methylbenzoate cellulose ...

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Numerical and experimental study of steam‐water two‐phase flow through steam jet pump

09.05.2013 | Ajmal Shah, Alamdar Hussain Khan, Imran Rafiq Chughtai, Mansoor Hameed Inayat, Asia-Pacific Journal of Chemical Engineering, 2013

ABSTRACT The Steam Jet Pump (SJP) is the most suitable pump for pumping radioactive and hazardous liquids because of its mechanical simplicity, no maintenance, low cost, easy construction, no leakage, simple control, and so on. The only problem with the SJP is the complexity in the ...

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Epoxy‐cyanate ester shape memory thermoset: some aspects of phase transition, viscoelasticity and shape memory characteristics

08.05.2013 | Biju Rajendran, Santhosh Kumar K. S., Rajeev R. S., C. P. Reghunadhan Nair, Polymers for Advanced Technologies, 2013

A shape memory thermoset comprising of a co‐reacted system of epoxy resin (diglycidylether of bisphenol A), cyanate ester (bisphenol A dicyanate ester) and phenol telechelic poly(tetramethylene oxide) (PTOH) was investigated for its morphology, viscoelasticity and shape memory ...

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Recovery performance and characteristics in shape memory effects of aliphatic polyether urethane

08.05.2013 | Ling Luo, Xiaoxia Wang, Yuxi Jia, Zhaojing Wang, Polymers for Advanced Technologies, 2013

The analysis on the recovery performance and characteristics in shape memory effects is helpful for the optimal design and engineering applications of shape memory polymers and their composites. To investigate the relationships among recovery performance, material parameters, and loading ...

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Electrospray tandem mass spectrometry analysis of methylenedioxy chalcones, flavanones and flavones

07.05.2013 | José C. J. M. D. S. Menezes, José A. S. Cavaleiro, Shrivallabh P. Kamat, Cristina M. R. F. Barros, M. Rosário M. Dom ..., Rapid Communications in Mass Spectrometry, 2013

RATIONALE Several methylenedioxy chalcones, flavanones and flavones substituted with mono‐, di‐ and trimethoxy groups have been used in the treatment of proliferative conditions like cancer and inflammatory diseases. The application of these flavonoids in biology requires an analytical ...

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Well‐defined thermoresponsive dendritic polyamide/poly(N‐vinylcaprolactam) block copolymers

03.05.2013 | Yunmei Bi, Caixian Yan, Lidong Shao, Yufei Wang, Yongcui Ma, Gang Tang, Journal of Polymer Science Part A: Polymer Chemistry, 2013

ABSTRACT The first‐ and second‐generation well‐defined thermoresponsive amphiphilic linear–dendritic diblock copolymers based on hydrophilic linear poly(N‐vinylcaprolactam) and hydrophobic dendritic aromatic polyamide have been synthesized via reversible addition fragmentation chain ...

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A dual‐level direct dynamics study on the hydrogen abstraction reaction of oxygen atom with methylhydrazine

30.04.2013 | Li Wang, Jinmiao Wen, Hongqing He, Jinglai Zhang, International Journal of Quantum Chemistry, 2013

The mechanism of the multichannel reaction CH3NHNH2 (SC1 and SC2) + O → products is investigated theoretically using ab initio and density functional theory, and dynamics properties are explored by a dual‐level direct dynamics method. The calculation of the potential energy surface is ...

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A study into Stille cross‐coupling reaction mediated by palladium catalysts deposited over siliceous supports bearing N‐donor groups at the surface

29.04.2013 | Miloslav Semler, Jiří Čejka, Petr Štěpnička, Applied Organometallic Chemistry, 2013

Mesoporous molecular sieve SBA‐15 and conventional silica gel were grafted with 3‐[2‐(diethylamino)ethylamino]propyl groups and used as supports for the preparation of deposited palladium catalysts, which were subsequently evaluated in Stille cross‐coupling reaction of aryl bromides. The ...

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