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CD46
| CD46 molecule, complement regulatory protein
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| PDB rendering based on 1ckl.
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| Available structures: 1ckl, 2o39
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| Identifiers
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| Symbol(s)
| CD46; MCP; MGC26544; MIC10; TLX; TRA2.10
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| External IDs
| OMIM: 120920 MGI: 1203290 Homologene: 7832
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| Gene Ontology
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| Molecular Function:
| • receptor activity
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| Cellular Component:
| • plasma membrane
• integral to plasma membrane
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| Biological Process:
| • complement activation, classical pathway
• single fertilization
• innate immune response
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| RNA expression pattern
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More reference expression data
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| Orthologs
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| Human
| Mouse
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| Entrez
| 4179
| 17221
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| Ensembl
| ENSG00000117335
| ENSMUSG00000016493
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| Uniprot
| P15529
| O88174
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| Refseq
| NM_002389 (mRNA)
NP_002380 (protein)
| NM_010778 (mRNA)
NP_034908 (protein)
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| Location
| Chr 1: 205.99 - 206.04 Mb
| Chr 1: 196.76 - 196.79 Mb
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| Pubmed search
| [1]
| [2]
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CD46 is an inhibitory complement receptor.
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. This gene is found in a cluster on chromosome 1q32 with other genes encoding structural components of the complement system. At least fourteen different transcript variants encoding fourteen different isoforms have been found for this gene.[1]
References
- ^ Entrez Gene: CD46 CD46 molecule, complement regulatory protein.
| Proteins: complement system (C, L, A) |
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| Activators | CLA: C3-convertase - MAC (C6, C7, C8, C9) - L: Mannan-binding lectin - A: Factor P/Properdin |
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| Enzymes | C: C1Q/C1R/C1S - C4 (A) - C2 - CLA: C3 - C5 (C5a) - L: MASP1 - MASP2 - A: Factor B - Factor D |
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| Inhibitors | CLA: C1-inhibitor - Decay accelerating factor - Factor I - CL: C4BP - A: Factor H |
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| Complement receptors | CR1 - CR2 - CR3 - CR4 - CD11b/CD11c/CD18 - Anaphylatoxin (C3a, C5a) |
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This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "CD46". A list of authors is available in Wikipedia.
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