Cafestol
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| Cafestol
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| Systematic (IUPAC) name
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(3bS,5aS,7R,8R,10aS,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-
7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol
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| Identifiers
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| CAS number
| 469-83-0
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| ATC code
| ?
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| PubChem
| ?
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| Chemical data
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| Formula | C20H28O3
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| Mol. mass | 316.439 g/mol
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| Physical data
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| Melt. point
| 158–162 °C (316–324 °F)
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| Pharmacokinetic data
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| Bioavailability | ?
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| Metabolism | ?
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| Half life | ?
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| Excretion | ?
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| Therapeutic considerations
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| Pregnancy cat.
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?
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| Legal status
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Legal everywhere
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| Routes
| Oral
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Cafestol is a diterpene molecule present in coffee.
A typical bean of Coffea arabica contains about 0.6% cafestol by weight. Cafestol is present in highest quantity in unfiltered coffee drinks such as French press coffee or Turkish coffee. In filtered coffee drinks such as drip brewed coffee, it is present in only negligible amounts.
Studies have shown that regular consumption of boiled coffee increases serum cholesterol by 8% in men and 10% in women. For those drinking filter coffee, the effect was only significant for women.
Cafestol has also shown anticarcinogenic properties in rats.
According to a 2005 study by the Baylor College of Medicine, cafestol may act as an agonist ligand for the genes FXR and PXR, blocking cholesterol homeostasis.
| Coffee |
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| Facts about coffee | History of coffee - Economics of coffee - Coffee and health |
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| Species and varieties | List of varieties - Coffea arabica: Kenya AA, Kona, Jamaican Blue Mountain - Coffea canephora (robusta): Kopi Luwak - Coffea liberica: Kape Barako |
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| Major chemicals in coffee | Caffeine - Cafestol |
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| Coffee bean processing | Coffee roasting - Home roasting coffee - Decaffeination |
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| Common beverage preparation | Coffee percolator - Espresso (lungo, ristretto) - Drip brew (from coffeemakers) - French press - Turkish coffee - Instant coffee - Chemex - Moka Express |
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| Popular coffee beverages | Americano/Long black - Café au lait/Café con leche - Cafe mocha - Cà phê sữa đá - Cappuccino - Coffee milk - Cortado - Greek frappé coffee
Indian filter coffee - Irish coffee - Latte/Flat white - Macchiato (espresso, latte) - Iced coffee - Iced cappuccino - Red eye |
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| Coffee and lifestyle | Social aspects of coffee - Coffeehouse - Caffè - Café - Caffè sospeso - Coffee cupping - Coffee break/Fika |
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