Danaparoid Danaparoid sodium (Orgaran®) is an anticoagulant that works by inhibiting activated factor X (factor Xa).
Danaparoid is considered a "low molecular weight heparin " by some sources, but is chemically distinct from heparin and thus has little cross-reactivity in heparin-intolerant patients.
Uses
It is used to prevent deep venous clots, particularly in situations with a high risk of clot formation, such as after hip surgery.
It is also used as a heparinoid substitute in heparin-induced thrombocytopenia which may otherwise cause paradoxical thrombosis.
Discontinuation
On August 14, 2002, this drug was withdrawn by Organon International .[1]
Administration
IV
IV and SC
Side effects
Bleeding problems
Low platelets, due to a low level of structural similarity between danaparoid and heparin
Asthma exacerbations, due to allergies to sulphites contained within the medicine
References
^ Antithrombotics (thrombolytics , anticoagulants and antiplatelet drugs ) (B01 ) Vitamin K antagonistsAcenocoumarol • Clorindione • Coumatetralyl • Dicumarol (Dicoumarol) • Diphenadione • Ethyl biscoumacetate • Phenprocoumon • Phenindione • Tioclomarol • Warfarin Heparin group Antithrombin III • Danaparoid • Heparin • Sulodexide • low molecular weight heparin Dalteparin , Enoxaparin , Nadroparin, Parnaparin, Reviparin, Tinzaparin)Glycoprotein IIb/IIIa inhibitors Abciximab • Eptifibatide • Tirofiban Other platelet Acetylsalicylic acid/Aspirin • Aloxiprin • Ditazole • Carbasalate calcium • Cloricromen • Dipyridamole • Indobufen • Picotamide • Triflusal • ADP receptor inhibitors (Clopidogrel , Ticlopidine , Prasugrel ) • prostaglandin analogue Beraprost , Prostacyclin , Iloprost , Treprostinil )Enzymes plasminogen activators (Alteplase/Reteplase/Tenecteplase, Streptokinase , Urokinase /Saruplase, Anistreplase) • other serine endopeptidases (Ancrod , Drotrecogin alfa/Protein C , Fibrinolysin ) • BrinaseDirect thrombin inhibitors Argatroban • Bivalirudin • Dabigatran • Desirudin • Hirudin • Lepirudin • Melagatran • Ximelagatran Other antithrombotics Defibrotide • Dermatan sulfate • Fondaparinux • Rivaroxaban Non-medicinal Citrate • EDTA • Oxalate
This article is licensed under the GNU Free Documentation License . It uses material from the Wikipedia article "Danaparoid" . A list of authors is available in Wikipedia.
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