STAT5
signal transducer and activator of transcription 5A
Identifiers
Symbol
STAT5A
Alt. Symbols
STAT5
Entrez
6776
HUGO
11366
OMIM
601511
RefSeq
NM_003152
UniProt
P42229
Other data
Locus
Chr. 17 q11.2
signal transducer and activator of transcription 5B
Identifiers
Symbol
STAT5B
Entrez
6777
HUGO
11367
OMIM
604260
RefSeq
NM_012448
UniProt
P51692
Other data
Locus
Chr. 17 q11.2
STAT5 refers to two highly related proteins , STAT5a and STAT5b. STAT5a and STA5b are encoded by separate genes, but are 90% identical at the amino acid level. [1]
References
^ Grimley PM, Dong F, Rui H. (1999) "Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation." in Cytokine Growth Factor Rev Volume 10 (2), pages 131-57. Entrez PubMed 10743504
Transcription factors and intracellular receptors (1) Basic domains
(1.1) Basic leucine zipper (bZIP)Activating transcription factor (1, 2, 3, 4, 5, 6) • AP-1 (c-Fos , FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3) • GABPA • MAF (B, F, G, K) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)ATOH1 • AhR • AHRR • ARNT • ASCL1 • BMAL (ARNTL, ARNTL2) • CLOCK • HIF (1A, 3A) • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • NEUROD1 • Twist • USF1
(1.3) bHLH-ZIP Myc • MITF • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH) AP-2
(2 ) Zinc finger
(2.1) Nuclear receptor (Cys4 ) subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR ) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen , Glucocorticoid , Mineralocorticoid , Progesterone )) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1 , SHP)
(2.2) Other Cys4 GATA (1 , 2, 3, 4, 5, 6)
(2.3) Cys2 His2 General transcription factors (TFIIA , TFIIB , TFIID , TFIIE , TFIIF , TFIIH: 1, 2) • GLI-Krüppel family (1 , 2 , 3 , YY1) • KLF (2, 4, 5, 6, 10, 11, 12, 13) • Sp1 • zinc finger (3, 35, 43, 146, 148, 165, 217, 268 , 281, 350) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6 HIVEP1
(3) Helix-turn-helix domains
(3.1) Homeo domain ARX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C6, C8, C9, C13, D1, D3, D4, D9, D10, D11, D12, D13) • NANOG • NKX (2-1, 2-5, 3-1) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4 , 6, 7)
(3.2) Paired box PAX (1, 2, 3, 4, 5, 6 , 7, 8, 9)
(3.3) Fork head / winged helix E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2 , E1, G1, H1, L2, M1, N3, O3, O4, P1, P2 , P3 )
(3.4) Heat Shock Factors HSF1
(3.5) Tryptophan clusters ELF (4, 5) • Interferon regulatory factors (1, 2, 3, 4, 5, 6 , 7, 8) • MYB
(3.6) TEA domain transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
(4.1) Rel homology region NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (5, C1, C2, C3, C4)
(4.2) STAT STAT (1 , 2 , 3 , 4 , 5 , 6 )
(4.3) p53 p53
(4.4) MADS box Mef2 (A, B, C, D) • SRF
(4.7) High mobility group HNF (1A, 1B) • LEF1 • SOX (3, 4, 6, 9, 10, 13, 18) • SRY • SSRP1
(4.10) Cold-shock domain CSDA
(4.11) Runt CBF (RUNX1, RUNX2, RUNX3)
(0) Other
(0.2) HMGI(Y) HMGA (1, 2)
(0.3) Pocket domainRb • RBL1 • RBL2
(0.6) Miscellaneous ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • Rho/Sigma • R-SMAD
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