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Molecules, Vol. 22, Pages 1413: Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities

Molecules, Vol. 22, Pages 1413: Dihydrochalcones and Diterpenoids from Pteris ensiformis and Their Bioactivities

Molecules doi: 10.3390/molecules22091413

Authors: Yu-Sheng Shi Yan Zhang Wen-Zhong Hu Xiu-Fu Zhang Xin Fu Xia Lv

Two new dihydrochalcone enantiomers (+)-1 and (−)-1, along with eight known compounds 3–10, were obtained from Pteris ensiformis. The planar structures were determined on the basis of extensive 1D and 2DNMR and HRESIMS. The resolution of (+)-1 and (−)-1 was achieved by chiral HPLC analysis. The absolute configurations of (+)-1 and (−)-1 were established by the bulkiness rule using Rh2(O2CCF3)4-induced circular dichroism (ICD) method. Compounds (+)-1, (−)-1, 8, 9 and 10 exhibited the inhibitory assay of NO production in mouse macrophages stimulated by LPS, with IC50 values of 2.0, 2.5, 8.0, 9.5 and 5.6 μM, respectively. Otherwise, compound 10 showed moderate cytotoxic activity against HCT-116, HepG-2 and BGC-823 cell lines with IC50 values of 3.0, 10.5 and 6.3 μM, respectively.

Autoren:   Shi, Yu-Sheng ; Zhang, Yan ; Hu, Wen-Zhong ; Zhang, Xiu-Fu ; Fu, Xin ; Lv, Xia
Journal:   Molecules
Band:   22
Ausgabe:   9
Jahrgang:   2017
Seiten:   1413
DOI:   10.3390/molecules22091413
Erscheinungsdatum:   25.08.2017
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