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Acetylcholine receptor antibody–mediated animal models of myasthenia gravis and the role of complement

Abstract

Because of the failure of many promising therapeutics identified in preclinical evaluation, funding sources have established guidelines for increased rigor in animal evaluations. The myasthenia gravis (MG) community of scientists has developed guidelines for preclinical assessment for potential MG treatments. Here, we provide a focused summary of these recommendations and the role of complement in disease development in experimental models of MG.

Autoren:   Linda L. Kusner, Manjistha Sengupta, Henry J. Kaminski
Journal:   Annals of the New York Academy of Sciences
Jahrgang:   2018
Seiten:   n/a
DOI:   10.1111/nyas.13555
Erscheinungsdatum:   21.01.2018
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