my.chemie.de
Mit einem my.chemie.de-Account haben Sie immer alles im Überblick - und können sich Ihre eigene Website und Ihren individuellen Newsletter konfigurieren.
Abstract
Because of the failure of many promising therapeutics identified in preclinical evaluation, funding sources have established guidelines for increased rigor in animal evaluations. The myasthenia gravis (MG) community of scientists has developed guidelines for preclinical assessment for potential MG treatments. Here, we provide a focused summary of these recommendations and the role of complement in disease development in experimental models of MG.
| Autoren: | Linda L. Kusner, Manjistha Sengupta, Henry J. Kaminski | |
| Journal: | Annals of the New York Academy of Sciences | |
| Jahrgang: | 2018 | |
| Seiten: | n/a | |
| DOI: | 10.1111/nyas.13555 | |
| Erscheinungsdatum: | 21.01.2018 |
The unfolding landscape of the congenital myasthenic syndromes
Abstract Congenital myasthenic syndromes (CMS) are heterogeneous disorders in which the safety margin of neuromuscular transmission is impaired by one or more specific mechanisms. Since the advent of next‐generation sequencing methods, the discovery of novel CMS targets and phenotypes ha ... mehr
Passive transfer models of myasthenia gravis with muscle‐specific kinase antibodies
Abstract Myasthenia gravis (MG) with antibodies to muscle‐specific kinase (MuSK) is characterized by fluctuating fatigable weakness. In MuSK MG, involvement of bulbar muscles, neck, and shoulder and respiratory weakness are more prominent than in acetylcholine receptor (AChR) MG. MuSK au ... mehr
Functions of autophagy in the tumor microenvironment and cancer metastasis
Abstract Macro‐autophagy is an ancient and highly‐conserved self‐degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens and protein aggregates. Autophagy, as it is routinely referred to, also allows cells to maintain metabolic sufficiency a ... mehr
Wiley ermöglicht Zugriff auf SpecInfo über Wiley InterScience
John Wiley & Sons, Inc. stellt die Datenbank SpecInfo erstmals über die dynamische Internet-Plattform Wiley InterScience online zur Verfügung. Mit über 434 000 regelmäßig gepflegten Einträgen gehört SpecInfo zu den weltweit größten Spektrensammlungen. SpecInfo bietet dem Benutzer eine int ... mehr
© 1997-2022 LUMITOS AG, All rights reserved
Fachpublikationen
