The unfolding landscape of the congenital myasthenic syndromes
Abstract
Congenital myasthenic syndromes (CMS) are heterogeneous disorders in which the safety margin of neuromuscular transmission is impaired by one or more specific mechanisms. Since the advent of next‐generation sequencing methods, the discovery of novel CMS targets and phenotypes ha ... mehr
Passive transfer models of myasthenia gravis with muscle‐specific kinase antibodies
Abstract
Myasthenia gravis (MG) with antibodies to muscle‐specific kinase (MuSK) is characterized by fluctuating fatigable weakness. In MuSK MG, involvement of bulbar muscles, neck, and shoulder and respiratory weakness are more prominent than in acetylcholine receptor (AChR) MG. MuSK au ... mehr
Functions of autophagy in the tumor microenvironment and cancer metastasis
Abstract
Macro‐autophagy is an ancient and highly‐conserved self‐degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens and protein aggregates. Autophagy, as it is routinely referred to, also allows cells to maintain metabolic sufficiency a ... mehr