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An Efficient One-Pot, Four-Component Synthesis of Pyrazolo[3,4-b]pyridines Catalyzed by Tetrapropylammonium Bromide (TPAB) in Water

Mahnaz Ezzati, Jabbar Khalafy, Ahmad Poursattar Marjani, Rolf H. Prager

A novel and one-pot pseudo-four-component reaction between a series of arylglyoxals, malononitrile, 3-methyl-1-phenyl-1H-pyrazol-5-amine, and acetone in the presence of TPAB has been developed to synthesize a series of new substituted pyrazolo[3,4-b]pyridines, using water as an environmentally friendly solvent, in high to excellent yields.


Autoren:   ie=edge
Journal:   Australian Journal of Chemistry
Jahrgang:   2018
DOI:   10.1071/CH17642
Erscheinungsdatum:   08.05.2018
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