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Computer simulations of the catalytic mechanism of wild-type and mutant β-phosphoglucomutase

β-Phosphoglucomutase (β-PGM) has served as an important model system for understanding biological phosphoryl transfer. This enzyme catalyzes the isomerization of β-glucose-1-phosphate to β-glucose-6-phosphate in a two-step process proceeding via a bisphosphate intermediate. The conventionally accepted mechan

Autoren:   Alexandre Barrozo; Qinghua Liao; Mauricio Esguerra; Gaël Marloie; Jan Florián; Nicholas H. Williams; Shina Caroline Lynn Kamerlin
Journal:   Organic & Biomolecular Chemistry
Band:   16
Ausgabe:   12
Seiten:   2060
DOI:   10.1039/C8OB00312B
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