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A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

We describe an expanded modular gastrointestinal (GI) tract–liver system by co-culture of primary human intestinal epithelial cells (hIECs) and 3D liver mimic. The two organ body-on-chip design consisted of GI and liver tissue compartments that were connected by fluidic medium flow driven via gravity. The hIECs and Organ-, body- and disease-on-a-chip systems

Autoren:   Huanhuan Joyce Chen; Paula Miller; Michael L. Shuler
Journal:   Lab on a Chip
DOI:   10.1039/C8LC00111A
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