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Materials, Vol. 11, Pages 1123: Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

Materials, Vol. 11, Pages 1123: Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

Materials doi: 10.3390/ma11071123

Authors: Sayed Ashfaq Ali Shah Melike Firlak Stuart Ryan Berrow Nathan Ross Halcovitch Sara Jane Baldock Bakhtiar Muhammad Yousafzai Rania M. Hathout John George Hardy

The delivery of drugs in a controllable fashion is a topic of intense research activity in both academia and industry because of its impact in healthcare. Implantable electronic interfaces for the body have great potential for positive economic, health, and societal impacts; however, the implantation of such interfaces results in inflammatory responses due to a mechanical mismatch between the inorganic substrate and soft tissue, and also results in the potential for microbial infection during complex surgical procedures. Here, we report the use of conducting polypyrrole (PPY)-based coatings loaded with clinically relevant drugs (either an anti-inflammatory, dexamethasone phosphate (DMP), or an antibiotic, meropenem (MER)). The films were characterized and were shown to enhance the delivery of the drugs upon the application of an electrochemical stimulus in vitro, by circa (ca.) 10–30% relative to the passive release from non-stimulated samples. Interestingly, the loading and release of the drugs was correlated with the physical descriptors of the drugs. In the long term, such materials have the potential for application to the surfaces of medical devices to diminish adverse reactions to their implantation in vivo.

Autoren:   Shah, Sayed Ashfaq Ali; Firlak, Melike ; Berrow, Stuart Ryan; Halcovitch, Nathan Ross; Baldock, Sara Jane; Yousafzai, Bakhtiar Muhammad; Hathout, Rania M.; Hardy, John George
Journal:   Materials
Band:   11
Ausgabe:   7
Jahrgang:   2018
Seiten:   1123
DOI:   10.3390/ma11071123
Erscheinungsdatum:   01.07.2018
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