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Formation of arrays of planar, murine, intestinal crypts possessing a stem/proliferative cell compartment and differentiated cell zone

A simple, in vitro intestinal model recapitulating key aspects of crypt architecture and physiology would facilitate our understanding the impact of drugs, foods and microbial metabolites on the intestine. To address the limitations of previously reported intestinal in vitro platforms, we developed a planar crypt a Organ-, body- and disease-on-a-chip systems

Autoren:   Raehyun Kim; Yuli Wang; Shee-Hwan J. Hwang; Peter J. Attayek; Nicole M. Smiddy; Mark I. Reed; Christopher E. Sims; Nancy L. Allbritton
Journal:   Lab on a Chip
DOI:   10.1039/C8LC00332G
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