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Novel 5[prime or minute]-deoxy nucleosyl amino acid scaffolds for the synthesis of muraymycin analogues

Naturally occurring nucleoside antibiotics such as muraymycins represent promising lead structures for the development of novel antibacterial agents. A concise synthesis of 5[prime or minute]-deoxy muraymycin derivatives has been developed. The key step was the highly stereoselective asymmetric hydrogenation of suitable didehydro amino acid precursors, providing unique nucleosyl amino acid structures.

Autoren:   Anatol P. Spork; Christian Ducho
Journal:   Organic & Biomolecular Chemistry
Band:   8
Ausgabe:   10
Jahrgang:   2010
Seiten:   2323
DOI:   10.1039/C003092A
Erscheinungsdatum:   12.04.2010
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