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Synthesis of () Travoprost and its Analogs

Abstract:

A new synthetic approach for the antiglaucoma agent, travoprost (1) has been developed in four steps from key intermediate (2). Key transformations include Horner-Wadsworth-Emmons reaction and separation of diastereomers to obtain (±) travoprost (1) and its analogs.

Autoren:   Mudduluru, Harikrishna; M Hindupur, Rama; K Dubey, Pramod; Madhavaram, Shankar; Tatini, Lakshmikumar; V Subbaraju, Gottumukkala
Journal:   Letters in Organic Chemistry
DOI:   10.2174/157017811795371485
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