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Disposable screen printed sensor for the electrochemical detection of delta-9-tetrahydrocannabinol in undiluted saliva
Background:
Cannabis has an adverse effect on the ability to drive safely, therefore a rapid disposable test for Δ
9
-tetrahydrocannabinol (Δ
9
-THC), the psychoactive component of cannabis, is highly desirable for roadside testing.
Results:
A screen printed carbon electrode is used for the N-(4-amino-3-methoxyphenyl)-methanesulfonamide mediated detection of Δ
9
-THC in saliva. Mediator placed in an overlayer was galvanostatically oxidized and reacted with Δ
9
-THC to give an electrochemically active adduct which could be detected by chronoamperometric reduction. Detection of 25-50 ng/mL Δ
9
-THC spiked into undiluted saliva was achieved with a response time of 30 s. A trial of the sensors with four cannabis smokers showed sensitivity of 28 %, specificity of 99 % and accuracy of 52 %.
Conclusions:
Rapid electrochemical detection of Δ
9
-THC in undiluted saliva has been demonstrated using a disposable sensor, however the sensitivity is lower than acceptable. Further optimization of the assay and sensor format is required to improve the sensitivity of response to Δ
9
-THC.
Background:
Hydrazones and their metal
complexes were heavily studied due to their pharmacological applications such as antimicrobial, anticonvulsant analgesic, anti-inflammatory and anti-cancer agents. This work aims to synthesize and characterize novel complexes of VO ... mehr
Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-consumption fruits in terms of energy, nutrients and health supplements. What is more, a number of these
fruits have been used as traditional medicinal herbs to cure diseases in several Asian cou ... mehr
Background:
The aim of the current work was to determine thermo dynamical properties of 5(2-nitro phenyl)-furan-2-carbaldehyde, 5(3-nitro phenyl)-furan-2-carbaldehyde and 5(4-nitro phenyl)-furan-2-carbaldehyde.
Results:
The temperature dependence of saturated vapor pressure of 5(2-nitro phe ... mehr