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3.062 Aktuelle Fachpublikationen von Bentham Science Publishers
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28.06.2017 | Rahnama Lakomehsari, Kaabeh; Taghvaei Ganjali, Saeed; Zadmard, Reza; Roshan, Mina, Letters in Organic Chemistry, 2017
Abstract: Background: Azocalix[4] arene derivative based on 2,6-diamino pyridine has been synthesized from diazo-coupling reaction between tetradiazonium salt of calix[4]arene and 2,6-diaminopyridine, and characterized by various spectroscopic methods such as IR, 1HNMR, 13CNMR and Mass ...
28.06.2017 | Wathieu, Henri; T. Issa, Naiem; Mohandoss, Manisha; W. Byers, Stephen; Dakshanamurthy, Sivanesan, Combinatorial Chemistry, 2017
Abstract: Background: Cancer-associated metabolites result from cell-wide mechanisms of dysregulation. The field of metabolomics has sought to identify these aberrant metabolites as disease biomarkers, clues to understanding disease mechanisms, or even as therapeutic agents. Objective: This ...
28.06.2017 | O. Achieng, Angela; Rawat, Manmeet; Ogutu, Bernhards; Guyah, Bernard; Michael Ong'echa, John; J. Perkins, Douglas; K ..., Current Topics in Medicinal Chemistry, 2017
Abstract: Background: Despite a reduction in the global burden of malaria, the disease remains responsible for 214 million cases and 438,000 deaths annually with 88% of the mortality occurring in sub-Saharan Africa. Malaria control largely depends on effective chemotherapy. However, the ...
28.06.2017 | R.S. Garcia, Celia; Alves, Eduardo; H. S. Pereira, Pedro; J. Bartlett, Paula; P. Thomas, Andrew; Mikoshiba, Katsuhik ..., Current Topics in Medicinal Chemistry, 2017
Abstract: Background: Phosphoinositides (PIs) and their derivatives are essential cellular components that form the building blocks for cell membranes and regulate numerous cell functions. Specifically, the ability to generate myo-inositol 1,4,5-trisphosphate (InsP3) via phospholipase C ...
28.06.2017 | Vijaya Prabhu, Sitrarasu; Tiwari, Kartikeya; Suryanarayanan, Venkatesan; Kumar Dubey, Vikash; Kumar Singh, Sanjeev, Combinatorial Chemistry, 2017
Abstract: Aim and Objective: Visceral leishmaniasis is a deadly disease left untreated in over 95% of cases. It is characterized by irregular bouts of fever, weight loss, enlargement of the spleen and liver, and anemia. It is highly endemic in the Indian subcontinent. CAAX prenyl protease I ...
28.06.2017 | M. Kamble, Sarika; M. Patel, Harun; N. Goyal, Sameer; N. Noolvi, Malleshappa; B. Mahajan, Umesh; Ojha, Shreesh; R. P ..., Combinatorial Chemistry, 2017
Abstract: Aim and Objective: Kelch like ECH-associated protein 1 (Keap1) and Nuclear factor-E2 related factor 2 (Nrf2) binding is a key step in the ubiquitination and degradation of Nrf2. The compounds inhibiting this binding exert antioxidant actions. Naturally occurring pentacyclic ...
28.06.2017 | Zhang, Chunyan; Li, Zhi; Ma, Jiahai; Zhang, Jing; Zhang, Longming; Li, Tao; Zheng, Shijian, Combinatorial Chemistry, 2017
Abstract: Background: Heterocyclic scaffold, benzotriazole and its derivatives are potential anaesthetic agents that act locally. Objective: QSAR and docking analysis of previously synthesized benzotriazolyl derivatives were modelled for their local anaesthetic action using computer ...
28.06.2017 | Pillai, Harikrishna; Singh Yadav, Brijesh; Chaturvedi, Navaneet; Tasleem Jan, Arif; Kumar Gupta, Girish; Hassan Baig ..., Combinatorial Chemistry, 2017
Abstract: Background: Regucalcin (RGN), a calcium regulating protein having anti-prolific, antiapoptotic functions, plays important part in the biosynthesis of ascorbic acid. It is a highly conserved protein that has been reported from many tissue types of various vertebrate species. ...
28.06.2017 | Kadian, Kavita; Gupta, Yash; Kempaiah, Prakasha; Gupta, Nikesh; Sharma, Arun; Rawat, Manmeet, Current Topics in Medicinal Chemistry, 2017
Abstract: Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic ...
28.06.2017 | Yu. Gorobets, Nikolay; V. Sedash, Yuriy; K. Singh, Brajendra; Poonam; Rathi, Brijesh, Current Topics in Medicinal Chemistry, 2017
Abstract: Background: Despite the substantial progress over the time, malaria remains a major public health concern and causing hundreds of thousands of deaths. Resistance to the available antimalarial therapy increases threat to the global public health. Objective: Overview of ...
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