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3.062 Aktuelle Fachpublikationen von Bentham Science Publishers

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A Facile and Efficient One-pot Three Component Route to New Bis(1,2,4- Oxadiazole) Linked with Polyoxyethylene Chain

28.06.2017 | Ghrab, Saad; Aroua, Lotfi; Beji, Mohamed, Letters in Organic Chemistry, 2017

Abstract: Background: The synthesis of effective drugs is very important for the scientist. Due to the beneficial pharmacological properties of certain molecules containing the 1,2,4-oxadiazole moiety, the aim of this manuscript is to develop a one pot three component reaction for the ...

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Chiron Approach to Formal Synthesis of 8,9-dideoxyneodysiherbaine (MSVIII-19)

28.06.2017 | Sanchez-Eleuterio, Alma; M. Mastranzo, Virginia; Quintero, Leticia; Sartillo-Piscil, Fernando, Letters in Organic Chemistry, 2017

Abstract: Background: The synthesis of biologically active model compounds represents a valuable tool for medicinal chemistry. In this regard, the synthesis of MSVII-19, a structurally simplified model compound of Dysiherbaine, developed by the group of Sasaki, was synthesized with the ...

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Challenges with Mosquito-borne Viral Diseases: Outbreak of the Monsters

28.06.2017 | Gautam, Renu; Mishra, Sweta; Milhotra, Archana; Nagpal, Ritika; Mohan, Mradul; Singhal, Anchal; Kumari, Pratibha, Current Topics in Medicinal Chemistry, 2017

Abstract: Background: The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and ...

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Metabolomics as a Functional Tool in Screening Gastro Intestinal Diseases: Where are we in High Throughput Screening?

28.06.2017 | Gundamaraju, Rohit; Vemuri, Ravichandra; Eri, Rajaraman; M. Ishiki, Hamilton; Coy-Barrera, Ericsson; Sastry Yarla, N ..., Combinatorial Chemistry, 2017

Abstract: Identifying novel bio markers in gastro intestinal disease is a promising method where a comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to ...

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A New MCR Strategy Generating a Collection of Skeletally Diverse Simple Molecules Combinatorially

28.06.2017 | Nandi, Sibaji; Gupta, Ajay; Kumar Pal, Amarta, Letters in Organic Chemistry, 2017

Abstract: Background: 1,4 Dihydropyridines (1,4 DHPs), chromeno[4,3-b] quinolines and pyrimido [4,5-b]quinolines are biologically and pharmaceutically important heterocycles. They are also present in many natural products. Many methods have been applied for their synthesis but each method ...

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Proteases in Mosquito Borne Diseases: New Avenues in Drug Development

28.06.2017 | Pant, A.; Pasupureddy, R.; Pande, V.; Seshadri, S.; Dixit, R.; C. Pandey, K., Current Topics in Medicinal Chemistry, 2017

Abstract: Introduction: Mosquito borne diseases continue to propagate and cause millions of deaths annually. They are caused either by protozoan parasites such as Plasmodium, Toxoplasma or by flaviviruses including Dengue and Zika. Among the proteome of such parasitic organisms, proteases ...

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Synthesis and Evaluation of Novel Pyrido[1,2-b][1,2,4]triazine-2,6-dione and Pyrido[1,2-b][1,2,4]triazepine-2,7-dione Derivatives as Antioxidant Agents

28.06.2017 | Serrar, Houda; Marmouzi, Iliais; Benzekri, Zakaria; Boukhris, Said; Hassikou, Amina; Faouzi, My El Abbes; Souizi, Ab ..., Letters in Organic Chemistry, 2017

Abstract: Background: During the last years, condensed pyridine compounds have received much attention because of their immense biological properties. In this article, a practical and efficient synthesis of their novel series pyrido[1,2-b][1,2,4]triazine-2,6-dione and ...

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A Rapid, Solvent-Free Deprotection of Methoxymethyl (MOM) Ethers by pTSA; An Eco-Friendly Approach

28.06.2017 | Pandurangan, Nanjan, Letters in Organic Chemistry, 2017

Abstract: Background: Ease of preparation and alkaline stability of methoxymethyl (MOM) makes it an important hydroxyl protecting group. A number of methods are available for the deprotection of MOM. Though the methods are good in general, they use solvents, require prolonged reaction time ...

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A Simple, Mild and Efficient Oxidation of Benzylic Alcohols in the Presence of NBS/KOAc in Aqueous Solution

28.06.2017 | Wu, Jianglong; Liu, Yan; Liu, Ping; Gu, Chengzhi, Letters in Organic Chemistry, 2017

Abstract: Background: The oxidation of benzylic alcohols to carbonyl compounds is a fundamental reaction in organic synthesis. In traditional oxidation processes, a large amount of toxic and volatile organic solvents and metal oxidants are used. Thus, developing environmentally benign ...

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Synchronized Fast SPE and UFLC Methods for the Analyses of Eight Antidiabetic Drugs in Human Plasma

28.06.2017 | Ali, Imran; K. Dutta, Kamlesh; K. Jain, Arvind; A. Alothman, Zeid; Alwarthan, Abdulrahman, Combinatorial Chemistry, 2017

Abstract: Aim and Objective: The population of diabetic patients is rapidly increasing globally. The treatment of these patients is a complex phenomenon due to the use of the different drugs. The present article reports a synchronized fast SPE-UFLC separation of eight antidiabetic drugs in ...

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