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Mycobacterial DNA Replication as a Target for Antituberculosis Drug Discovery

28.06.2017 | PŦ#130;ocinska, Renata; Korycka-Machala, Malgorzata; Plocinski, Przemyslaw; Dziadek, Jaroslaw, Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, is a leading infectious disease organism, causing millions of deaths each year. This serious pathogen has been greatly spread worldwide and recent years have observed an increase in the ...

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Synthesis, Properties, and Mechanism of Action of New Generation of Polycyclic Glycopeptide Antibiotics

28.06.2017 | N. Olsufyeva, Eugenia; N. Tevyashova, Anna, Current Topics in Medicinal Chemistry, 2017

Abstract: Introduction: The increased resistance of glycopeptide based antibiotics has become a serious problem for the chemotherapy of infections triggered by resistant Gram-positive bacteria. This has motivated the urgent sincere efforts to develop potent glycopeptide-based antibiotics in ...

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The Metabolomic Strategy in Tuberculosis Therapy

28.06.2017 | Kumar, Nitendra; Kumar Shreshtha, Ashwinee; Patra, Sanjukta, Combinatorial Chemistry, 2017

Abstract: Tuberculosis causes around 1.4 million deaths every year remaining to be a major cause of morbidity and mortality. Mycobacterium tuberculosis is adept at surviving the assault of our immune system, which has perplexed many researchers. Not only are they difficult to treat, but ...

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Constituents from Ircinia echinata and their Antiproliferative Effect on Six Human Cancer Cell Strains

28.06.2017 | Van Kiem, Phan; Thi Dung, Duong; Thi Trang, Do; Hong Quang, Tran; Thi Thanh Ngan, Nguyen; Minh Ha, Tran; Le Tuan Anh ..., Letters in Organic Chemistry, 2017

Abstract: Background: Marine sponges have produced a large number of secondary metabolites and become a potent source of anti-cancer agents for drugs discovery. Screening results indicated that methanol extract of the sponge Ircinia echinata significantly induced in vitro antiproliferative ...

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Fungal Biotechnology of the Red Sea Alga Sarggassum subrepandum with Potential of Anticancer and Anti-Hepatitis C Virus Protease Activities

28.06.2017 | W. Hawas, Usama; Al-Farawati, Radwan; T. Abou El-Kassem, Lamia; F. Ahmed, Eman, Letters in Organic Chemistry, 2017

Abstract: Background: Marine algal-derived endophytic fungi have attracted considerable attention in the recent decade due to their prolific production of structurally diverse secondary metabolites with various biological activities. In this study, the potential inhibition of endophytic ...

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The Chemistry of α,β-Ditosyloxy Ketones: Hypervalent Iodine (III) Mediated Synthesis of Alkynes from α,β-Unsaturated Carbonyl Compounds Containing Pyrazole Moiety

28.06.2017 | Ranjan, Pooja; Arora, Loveena; Prakash, Richa; K. Aneja, Deepak; Prakash, Om, Letters in Organic Chemistry, 2017

Abstract: Background: The present study is an effort to extend the utility of the α,β-ditosyloxy chalcone derivatives in establishing the reaction patterns of these compounds which at once was thought that they might behave similar to α,β-dibromo ketones but the results obtained were quite ...

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Synthesis of Internal gem-Diborylalkanes by Copper-Catalyzed Double Hydroboration of Conjugated Internal Alkynes

28.06.2017 | Netsu, Yuma; Tsukada, Naofumi, Letters in Organic Chemistry, 2017

Abstract: Background: Geminal diboryl reagents have attracted considerable attention due to their unique reactivities. Double hydroboration of alkynes is a convenient and useful method for the synthesis of diborylalkanes. However, the double hydroboration is applied mainly to terminal alkynes. ...

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N-Acetylation of Aromatic Amines by the Soil Fungus Aspergillus japonicus (UFMS 48.136)

28.06.2017 | P. de Lima, Denis; C. Giannesi, Giovana; dos Anjos dos Santos, Edson; S. Ebbing Freitas, Thais; S. Lopes, Rosangela; ..., Letters in Organic Chemistry, 2017

Abstract: Background: Fungi can play an important role in environmental remediation. A key class of pollutants is the aromatic amines (AA) comprising dyes, drugs, pesticides and products originated from combustion and other industrial residues. The microbial N-acetylation is known to be a ...

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The Chemistry of the Canthin-4-ones

13.06.2017 | Bracher, Franz; Tremmel, Tim, Mini-Reviews in Organic Chemistry, 2017

Abstract: Background: The canthin-4-ones are a small, yet underexplored class of natural products from Apocynaceae plants. Efficient synthetic approaches are required for exploring this class of natural products for drug discovery. Objective: In this review, the synthetic approaches ...

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Intramolecular Pericyclic Reactions of Acetylene Derivatives Leading to Dehydroaromatic and Related Species

13.06.2017 | E. Lewis, David, Mini-Reviews in Organic Chemistry, 2017

Abstract: Alkynes and cumulenes share the common feature of at least one sp-hybridized carbon atom in the molecule. This leads to the molecules having relatively high energy in the thermodynamic sense, but also having high stability in the kinetic sense. Enediynes, enyne-cumulenes and ...

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