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Disposable screen printed sensor for the electrochemical detection of delta-9-tetrahydrocannabinol in undiluted saliva

21.01.2016 | Wanklyn, Ceri; Burton, Dan; Enston, Emma; Bartlett, Carrie-Ann; Taylor, Sarah; Raniczkowska, Aleksandra; Black, Murd ..., Chemistry Central Journal , 2016

Background: Cannabis has an adverse effect on the ability to drive safely, therefore a rapid disposable test for Δ 9 -tetrahydrocannabinol (Δ 9 -THC), the psychoactive component of cannabis, is highly desirable for ...


Spectral, thermal, molecular modeling and biological studies on mono- and binuclear complexes derived from oxalo bis(2,3-butanedionehydrazone)

29.12.2015 | El-Asmy, Ahmed; Jeragh, Bakir; Ali, Mayada, Chemistry Central Journal , 2015

Background: Hydrazones and their metal complexes were heavily studied due to their pharmacological applications such as antimicrobial, anticonvulsant analgesic, anti-inflammatory and anti-cancer agents. This work aims to synthesize and characterize novel complexes of VO ...


Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health

24.12.2015 | Lv, Xinmiao; Zhao, Siyu; Ning, Zhangchi; Zeng, Honglian; Shu, Yisong; Tao, Ou; Xiao, Cheng; Lu, Cheng; Liu, Yuanyan, Chemistry Central Journal , 2015

Citrus fruits, which are cultivated worldwide, have been recognized as some of the most high-consumption fruits in terms of energy, nutrients and health supplements. What is more, a number of these fruits have been used as traditional medicinal herbs to cure diseases in several Asian ...


Thermodynamic properties of 5(nitrophenyl) furan-2-carbaldehyde isomers

09.12.2015 | Dibrivnyi, Volodymyr; Sobechko, Iryna; Puniak, Marian; Horak, Yuriy; Obushak, Mykola; Van-Chin-Syan, Yuriy; Andriy, ..., Chemistry Central Journal , 2015

Background: The aim of the current work was to determine thermo dynamical properties of 5(2-nitro phenyl)-furan-2-carbaldehyde, 5(3-nitro phenyl)-furan-2-carbaldehyde and 5(4-nitro phenyl)-furan-2-carbaldehyde. Results: The temperature dependence of saturated vapor pressure of 5(2-nitro ...


Tissue-specific metabolite profiling and quantitative analysis of ginsenosides in Panax quinquefolium using laser microdissection and liquid chromatography–quadrupole/time of flight-mass spectrometry

09.12.2015 | Chen, Yujie; Xu, Liang; Zhao, Yuancen; Zhao, Zhongzhen; Chen, Hubiao; Yi, Tao; Qin, Minjian; Liang, Zhitao, Chemistry Central Journal , 2015

Background: The root of Panax quinquefolium L., famous as American ginseng all over the world, is one of the most widely-used medicinal or edible materials. Ginsenosides are recognized as the main bioactive chemical components responsible for various functions of American ginseng. In this study, ...


Using C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseases

26.11.2015 | Chen, Xi; Barclay, Jeff W; Burgoyne, Robert D; Morgan, Alan, Chemistry Central Journal , 2015

Age-associated neurodegenerative disorders such as Alzheimer’s disease are a major public health challenge, due to the demographic increase in the proportion of older individuals in society. However, the relatively few currently approved drugs for these conditions provide only symptomatic relief. ...


Silica-titania xerogel for solid phase spectrophotometric determination of salicylate and its derivatives in biological liquids and pharmaceuticals

25.11.2015 | Morosanova, Maria A; Morosanova, Elena I, Chemistry Central Journal , 2015

Background: Salicylic acid and its derivatives are widely used drugs with potential toxicity. The main areas of salicylate derivatives determination are biological liquids and pharmaceuticals analysis. Results: Silica-titania xerogel has been used for solid phase spectrophotometric determination ...


A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein—Destabilase-Lysozyme from medicinal leech

21.11.2015 | Kurdyumov, Alexey S; Manuvera, Valentin A; Baskova, Isolda P; Lazarev, Vassili N, BMC Biochemistry, 2015

Background: Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has been shown to exhibit isopeptidase, muramidase and antibacterial activity. This enzyme attracts interest because it expresses ...


Synthesis and dynamics studies of barbituric acid derivatives as urease inhibitors

17.11.2015 | Barakat, Assem; Al-Majid, Abdullah M; Lotfy, Gehad; Arshad, Fiza; Yousuf, Sammer; Choudhary, M. I; Ashraf, Sajda; Ul ..., Chemistry Central Journal , 2015

Background: Discovery of potent inhibitors of urease (jack bean) enzyme is the first step in the development of drugs against diseases caused by ureolytic enzyme. Results: Thirty-two derivatives of barbituric acid as zwitterionic adducts of diethyl ammonium salts were synthesized. All synthesized ...


The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes

11.11.2015 | Morrill, Johan; Kulcinskaja, Evelina; Sulewska, Anna M; Lahtinen, Sampo; Stålbrand, Henrik; Svensson, Birte; Abou Ha ..., BMC Biochemistry, 2015

Background: β-Mannans are abundant and diverse plant structural and storage polysaccharides. Certain human gut microbiota members including health-promoting Bifidobacterium spp. catabolize dietary mannans. Little insight is available on the enzymology of mannan deconstruction in the gut ...


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