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451 Aktuelle Fachpublikationen von BioMed Central


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Identification of structural alerts for liver and kidney toxicity using repeated dose toxicity data

05.11.2015 | Pizzo, Fabiola; Gadaleta, Domenico; Lombardo, Anna; Nicolotti, Orazio; Benfenati, Emilio, Chemistry Central Journal , 2015

Background: The potential for a compound to cause hepatotoxicity and nephrotoxicity is a matter of extreme interest for human health risk assessment. To assess liver and kidney toxicity, repeated-dose toxicity (RDT) studies are conducted mainly on rodents. However, these tests are expensive, ...


Biosynthesis of silver nanoparticles using Artocarpus elasticus stem bark extract

02.11.2015 | Abdullah, Nur ISB; Ahmad, Mansor B; Shameli, Kamyar, Chemistry Central Journal , 2015

Background: Green approach in synthesizing metal nanoparticles has gain new interest from the researchers as metal nanoparticles were widely applied in medical equipment and household products. The use of plants in the synthesis of nanoparticles emerges as a cost effective and eco-friendly ...


The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity

23.10.2015 | Gutiérrez-Fernández, Mario J; Higareda-Mendoza, Ana E; Gómez-Correa, César A; Pardo-Galván, Marco A, BMC Biochemistry, 2015

Background: eIF3f is a multifunctional protein capable of interacting with proteins involved in different cellular processes, such as protein synthesis, DNA repair, and viral mRNA edition. In human cells, eIF3f is related to cell cycle and proliferation, and its deregulation compromises cell ...


The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2

23.10.2015 | Viana, Rosa; Lujan, Pablo; Sanz, Pascual, BMC Biochemistry, 2015

Background: Lafora disease (LD, OMIM 254780) is a fatal neurodegenerative disorder produced mainly by mutations in two genes: EPM2A, encoding the dual specificity phosphatase laforin, and EPM2B, encoding the E3-ubiquitin ligase malin. Although it is known that laforin and malin may form a ...


Evaluating the role of a trypsin inhibitor from soap nut (Sapindus trifoliatus L. Var. Emarginatus) seeds against larval gut proteases, its purification and characterization

22.10.2015 | Gandreddi, V D Sirisha; Kappala, Vijaya R; Zaveri, Kunal; Patnala, Kiranmayi, BMC Biochemistry, 2015

Background: The defensive capacities of plant protease Inhibitors (PI) rely on inhibition of proteases in insect guts or those secreted by microorganisms; and also prevent uncontrolled proteolysis and offer protection against proteolytic enzymes of pathogens. Methods: An array of chromatographic ...


Synthesis and antibacterial and antifungal activities of N-(tetra-O-acetyl-β-d-glucopyranosyl)thiosemicarbazones of substituted 4-formylsydnones

19.10.2015 | Thanh, Nguyen D; Duc, Hoang T; Duyen, Vu T; Tuong, Phan M; Van Quoc, Nguyen, Chemistry Central Journal , 2015

Background: Sydnone is a heterocycle that exhibits remarkable pharmacological activities, including antimicrobial, anti-inflammatory, analgesic, antipyretic and antioxidant activities. Thiosemicarbazones are of compounds that contain the –NHCSNHN=C< linkage group and are considerable interest ...


A comparative study of electrochemical oxidation of methidation organophosphorous pesticide on SnO 2 and boron-doped diamond anodes

16.10.2015 | Hachami, Fatima; Errami, Mohamed; Bazzi, Lahcen; Hilali, Mustapha; Salghi, Rachid; Jodeh, Shehdeh; Hammouti, Belkhei ..., Chemistry Central Journal , 2015

Background: Electrochemical oxidation considered to be among the best methods in waste water desalination and removing toxic metals and organic pesticides from wastewater like Methidathion. The objective of this work is to study the electrochemical oxidation of aqueous wastes containing ...


Using water–solvent systems to estimate in vivo blood–tissue partition coefficients

16.10.2015 | Derricott, Caitlin E; Knight, Emily A; Acree, William E; Lang, Andrew SID, Chemistry Central Journal , 2015

Background: Blood–tissue partition coefficients indicate how a chemical will distribute throughout the body and are an important part of any pharmacokinetic study. They can be used to assess potential toxicological effects from exposure to chemicals and the efficacy of potential novel drugs ...


Content of micronutrients, mineral and trace elements in some Mediterranean spontaneous edible herbs

14.10.2015 | Volpe, Maria G; Nazzaro, Melissa; Di Stasio, Michele; Siano, Francesco; Coppola, Raffaele; De Marco, Anna, Chemistry Central Journal , 2015

Background: The analysis of mineral elements composition was determined in three wild edible herbs (Cichorium intybus L., Sonchus asper L. and Borago officinalis) collected in seven different sampling sites which were characterized by different pollution grade. The detection of mineral elements ...


The acrylamide content of smokeless tobacco products

12.10.2015 | McAdam, Kevin; Kimpton, Harriet; Vas, Carl; Rushforth, David; Porter, Andrew; Rodu, Brad, Chemistry Central Journal , 2015

Background: There is considerable interest from a regulatory and public health perspective in harmful and potentially harmful constituents in tobacco products, including smokeless tobacco products (STPs). A wide range of commercial STPs from the US and Sweden, representing 80–90% of the 2010 ...


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