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819 Aktuelle Fachpublikationen von de Gruyter


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Review: The hCG assay or pregnancy test

13.12.2011 | Laurence A. Cole, Clinical Chemistry , 2011

Abstract This review examines human chorionic gonadotropin (hCG) or pregnancy tests from multiple perspectives. It first investigates the molecule hCG and shows that the term represents five independent molecules differing in carbohydrate and meric structure that share a common amino acid ...


Monitoring quality indicators in laboratory medicine does not automatically result in quality improvement

13.12.2011 | Laura Sciacovelli; Oswald Sonntag; Andrea Padoan; Carlo Federico Zambon; Paolo Carraro; Mario Plebani, Clinical Chemistry , 2011

Abstract Background: Data on quality indicators (QIs) should be collected over time in order to identify and continuously monitor clinical laboratory performance and to improve patient safety by identifying and implementing effective interventions. The aim of the present study was to ascertain ...


Soluble transcobalamin receptor, sCD320, is present in human serum and relates to serum cobalamin – establishment and validation of an ELISA

13.12.2011 | Johan Frederik Berg Arendt; Edward V. Quadros; Ebba Nexo, Clinical Chemistry , 2011

Abstract Background: The cell-surface receptor, TCblR/CD320, binds and internalizes transcobalamin-bound cobalamin. So far, no assay has been developed in order to quantify the soluble form of the receptor. Methods: This study developed an ELISA employing a monoclonal antibody that recognized the ...


Demasking of epithelial cell adhesion molecule (EpCAM) on circulating epithelial tumor cells by Tween®20 treatment in breast cancer patients

13.12.2011 | Katya Hekimian; Ernst-Ludwig Stein; Ulrich Pachmann; Katharina Pachmann, Clinical Chemistry , 2011

Abstract Background: The epithelial cell adhesion molecule (EpCAM) embedded in the plasma membrane of circulating epithelial tumor cells (CETC) is used for detection and enrichment of circulating tumor cells in peripheral blood and as a target for anti-epithelial antibodies elicited during immune ...


A comparative analysis of the Iris iQ200 with manual microscopy as a diagnostic tool for dysmorphic erythrocytes in urine

13.12.2011 | Leonie A. Boven; Hans Kemperman; Ayşe Y. Demir, Clinical Chemistry , 2011

Clinical Chemistry and Laboratory Medicine, Volume 0, Issue 0, Page -, Ahead of Print.


Comparison of different collection procedures and two methods for DNA isolation from saliva

13.12.2011 | Jaroslava Durdiaková; Natália Kamodyová; Daniela Ostatníková; Barbora Vlková; Pete ..., Clinical Chemistry , 2011

Abstract Background: The non-invasive, flexible and easy sample collection makes saliva an interesting source of DNA for research and diagnostic purposes. The aim of our study was to find the most suitable collection method for biological material from the oral cavity and the most effective DNA ...


Faecal haemoglobin concentrations by gender and age: implications for population-based screening for colorectal cancer

13.12.2011 | Paula J. McDonald; Judith A. Strachan; Jayne Digby; Robert J.C. Steele; Callum G. Fraser, Clinical Chemistry , 2011

Abstract Background: Faecal immunochemical tests (FIT) are becoming widely used in colorectal cancer screening. Estimation of faecal haemoglobin concentration in a large group prompted an observational study on gender and age. Methods: A single estimate of faecal haemoglobin concentration was ...


Serum mesothelin and megakaryocyte potentiating factor in pancreatic and biliary cancers

13.12.2011 | Elad Sharon; Jingli Zhang; Kevin Hollevoet; Seth M. Steinberg; Ira Pastan; Masanori Onda; Jochen Gaedcke; B. ..., Clinical Chemistry , 2011

Abstract Background: Tumor mesothelin overexpression is present in different malignancies, including the majority of patients with pancreatic or biliary cancers. The objective of this study was to evaluate the use of shed serum mesothelin and megakaryocyte potentiating factor (MPF) concentrations ...


Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors

13.12.2011 | Igor Mindukshev; Stepan Gambaryan; Linda Kehrer; Claudia Schuetz; Anna Kobsar; Natalia Rukoyatkina; Viacheslav ..., Clinical Chemistry , 2011

Abstract Background: Determinations of platelet receptor functions are indispensable diagnostic indicators of cardiovascular and hemostatic diseases including hereditary and acquired receptor defects and receptor responses to drugs. However, presently available techniques for assessing platelet ...


Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer

13.12.2011 | Jamshid Farahati; Dirk Roggenbuck; Elena Gilman; Martin Schütte; Elena Jagminaite; Rasoul Seyed Zakavi; T ..., Clinical Chemistry , 2011

Abstract Background: The presence of thyroid peroxidase antibodies (TPOab) are reported to be associated with improved outcome among breast cancer patients. We evaluated the correlation between TPOab and diagnostic parameters among newly diagnosed breast cancer patients. Methods: Three hundred ...


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