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2.373 Aktuelle Fachpublikationen in Analytical and Bioanalytical Chemistry

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Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC/MS/MS

27.11.2012 | Lucie Stuchlíková, Robert Jirásko, Ivan Vokřál, Jiří Lamka, Marcel Špulák, Michal Holčapek, Barbora Szotáková, Hana ..., Analytical and Bioanalytical Chemistry, 2012

Monepantel (MOP) belongs to a new class of anthelmintic drugs known as aminoacetonitrile derivatives. It was approved for use in veterinary practice in Czech Republic in 2011. So far, biotransformation and transport of MOP in target animals have been studied insufficiently, although the study of ...

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Characterization of the alkaloids in goldenseal (Hydrastis canadensis) root by high resolution Orbitrap LC-MSn

25.11.2012 | Phuong Mai Le, Margaret McCooeye, Anthony Windust, Analytical and Bioanalytical Chemistry, 2012

Liquid chromatography coupled to multistage mass spectrometry (LC-MSn) is being used increasingly in pharmaceutical research and for quality control in herbal medicines because of its superior sensitivity and selectivity. In this study, a rapid, high-resolution liquid chromatography-mass ...

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Populus nigra L. bud absolute: a case study for a strategy of analysis of natural complex substances

25.11.2012 | Patrizia Rubiolo, Cristina Casetta, Cecilia Cagliero, Hugues Brevard, Barbara Sgorbini, Carlo Bicchi, Analytical and Bioanalytical Chemistry, 2012

The new European regulations (e.g., REACH) require that Natural Complex Substances such as essential oils, absolutes, concretes, and resinoids are registered. This need implies that the chemical composition of these complex mixtures is characterized as exhaustively as possible in view of defining ...

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Optimizing hollow-fiber-based pharmacokinetic assay via chemical stability study to account for inaccurate simulated drug clearance of rifampicin

25.11.2012 | Lee Sun New, Tze Peng Lim, Jing Wen Oh, Gavin Jia Sheng Cheah, Andrea L. Kwa, Eric Chun Yong Chan, Analytical and Bioanalytical Chemistry, 2012

With increasing multidrug resistance coupled to a poor development pipeline, clinicians are exploring antimicrobial combinations to improve treatment outcomes. In vitro hollow-fiber infection model (HFIM) is employed to simulate human in vivo drug clearance and investigate pharmacodynamic ...

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Determination of 32 cathinone derivatives and other designer drugs in serum by comprehensive LC-QQQ-MS/MS analysis

25.11.2012 | Madeleine J. Swortwood, Diane M. Boland, Anthony P. DeCaprio, Analytical and Bioanalytical Chemistry, 2012

Recently, clandestine drug lab operators have attempted to bypass controlled substances laws and regulations with “designer” compounds chemically and pharmacologically similar to controlled substances. For example, “bath salts” have erupted onto the scene as “legal highs” containing cathinone ...

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Ambient analysis by thermal desorption atmospheric pressure photoionization

25.11.2012 | Kaveh Jorabchi, Karl Hanold, Jack Syage, Analytical and Bioanalytical Chemistry, 2012

Ambient mass spectrometry has attracted substantial attention in recent years. Among ambient ionization methods, thermal desorption ionization stands out because of two attributes: (1) simplicity, rendering the technique suitable for in-field applications, and (2) ability to couple with a variety ...

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Development, optimization, and use of an APCI source with temperature-controlled vaporization of solid and liquid samples

25.11.2012 | Sonja Krieger, Alexandra von Trotha, Kelvin Sze-Yin Leung, Oliver J. Schmitz, Analytical and Bioanalytical Chemistry, 2012

A trend is observed in mass spectrometry, in which solid samples without prior dissolution and chromatographic separation are brought directly into the ion source and are ionized, e.g., by corona discharge (Atmospheric Solids Analysis Probe) or plasma (Direct Analysis in Real Time). The Direct ...

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Detection of flagellin by interaction with human recombinant TLR5 immobilized in liposomes

25.11.2012 | Y. Olguín, P. Villalobos, L. G. Carrascosa, M. Young, E. Valdez, L. Lechuga, R. Galindo, Analytical and Bioanalytical Chemistry, 2012

Digestive diseases caused by flagellated bacteria are a huge public health problem worldwide and rapid detection methods are needed for contaminated environments. In this study, we propose a method to detect patterns associated with pathogens based on the properties of the innate immune system. ...

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Effects of the expression level of epidermal growth factor receptor on the ligand-induced restructuring of focal adhesions: a QCM-D study

25.11.2012 | Marcela P. Garcia, Ammar Shahid, Jennifer Y. Chen, Jun Xi, Analytical and Bioanalytical Chemistry, 2012

Epidermal growth factor receptor (EGFR) plays a major role in cell migration and invasion and is considered to be the primary source of activation of various malignant tumors. To gain insight into how elevated levels of EGFR influence cellular function, particularly cell motility, we used a ...

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Characterisation and quantification of liposome-type nanoparticles in a beverage matrix using hydrodynamic chromatography and MALDI–TOF mass spectrometry

25.11.2012 | Johannes P. F. G. Helsper, Ruud J. B. Peters, Lambertus Brouwer, Stefan Weigel, Analytical and Bioanalytical Chemistry, 2012

This paper describes the characterisation of liposome-type nanoparticles (NPs) dispersed in a beverage matrix. Characterisation is based on a two-step procedure: first, liposomes are separated on the basis of size in the nanometre range by use of hydrodynamic chromatography (HDC); second, ...

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