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146 Aktuelle Fachpublikationen in BMC Biochemistry

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A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein—Destabilase-Lysozyme from medicinal leech

21.11.2015 | Kurdyumov, Alexey S; Manuvera, Valentin A; Baskova, Isolda P; Lazarev, Vassili N, BMC Biochemistry, 2015

Background: Destabilase-Lysozyme (mlDL) is a multifunctional i-type enzyme that has been found in the secretions from the salivary glands of medicinal leeches. mlDL has been shown to exhibit isopeptidase, muramidase and antibacterial activity. This enzyme attracts interest because it expresses ...

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The GH5 1,4-β-mannanase from Bifidobacterium animalis subsp. lactis Bl-04 possesses a low-affinity mannan-binding module and highlights the diversity of mannanolytic enzymes

11.11.2015 | Morrill, Johan; Kulcinskaja, Evelina; Sulewska, Anna M; Lahtinen, Sampo; Stålbrand, Henrik; Svensson, Birte; Abou Ha ..., BMC Biochemistry, 2015

Background: β-Mannans are abundant and diverse plant structural and storage polysaccharides. Certain human gut microbiota members including health-promoting Bifidobacterium spp. catabolize dietary mannans. Little insight is available on the enzymology of mannan deconstruction in the gut ...

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The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity

23.10.2015 | Gutiérrez-Fernández, Mario J; Higareda-Mendoza, Ana E; Gómez-Correa, César A; Pardo-Galván, Marco A, BMC Biochemistry, 2015

Background: eIF3f is a multifunctional protein capable of interacting with proteins involved in different cellular processes, such as protein synthesis, DNA repair, and viral mRNA edition. In human cells, eIF3f is related to cell cycle and proliferation, and its deregulation compromises cell ...

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The laforin/malin E3-ubiquitin ligase complex ubiquitinates pyruvate kinase M1/M2

23.10.2015 | Viana, Rosa; Lujan, Pablo; Sanz, Pascual, BMC Biochemistry, 2015

Background: Lafora disease (LD, OMIM 254780) is a fatal neurodegenerative disorder produced mainly by mutations in two genes: EPM2A, encoding the dual specificity phosphatase laforin, and EPM2B, encoding the E3-ubiquitin ligase malin. Although it is known that laforin and malin may form a ...

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Evaluating the role of a trypsin inhibitor from soap nut (Sapindus trifoliatus L. Var. Emarginatus) seeds against larval gut proteases, its purification and characterization

22.10.2015 | Gandreddi, V D Sirisha; Kappala, Vijaya R; Zaveri, Kunal; Patnala, Kiranmayi, BMC Biochemistry, 2015

Background: The defensive capacities of plant protease Inhibitors (PI) rely on inhibition of proteases in insect guts or those secreted by microorganisms; and also prevent uncontrolled proteolysis and offer protection against proteolytic enzymes of pathogens. Methods: An array of chromatographic ...

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Respiration and substrate transport rates as well as reactive oxygen species production distinguish mitochondria from brain and liver

10.09.2015 | Gusdon, Aaron M; Fernandez-Bueno, Gabriel A; Wohlgemuth, Stephanie; Fernandez, Jenelle; Chen, Jing; Mathews, Clayton E, BMC Biochemistry, 2015

Background: Aberrant mitochondrial function, including excessive reactive oxygen species (ROS) production, has been implicated in the pathogenesis of human diseases. The use of mitochondrial inhibitors to ascertain the sites in the electron transport chain (ETC) resulting in altered ROS ...

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Complex kinetics and residual structure in the thermal unfolding of yeast triosephosphate isomerase

03.09.2015 | Labastida-Polito, Ariana; Garza-Ramos, Georgina; Camarillo-Cadena, Menandro; Zubillaga, Rafael A; Hernández-Arana, A ..., BMC Biochemistry, 2015

Background: Saccharomyces cerevisiae triosephosphate isomerase (yTIM) is a dimeric protein that shows noncoincident unfolding and refolding transitions (hysteresis) in temperature scans, a phenomenon indicative of the slow forward and backward reactions of the native-unfolded process. Thermal ...

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Purification and characterization of a cytochrome c with novel caspase-3 activation activity from the pathogenic fungus Rhizopus arrhizus

03.09.2015 | Saxena, Manoj; Sharma, Rohit K; Ramirez-Paz, Josell; Tinoco, Arthur D; Griebenow, Kai, BMC Biochemistry, 2015

Background: Members of Rhizopus species are the most common cause of mucormycosis, a rare but often fatal fungal infection. Host induced pathogen apoptosis and pathogen induced host cell apoptosis are often involved in fungal infections. In many organisms, the release of mitochondrial cytochrome ...

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Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

19.08.2015 | Neumann, Terrence S; Span, Elise A; Kalous, Kelsey S; Bongard, Robert; Gastonguay, Adam; Lepley, Michael A; Kutty, R ..., BMC Biochemistry, 2015

Background: Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domain of DUSP5. Methods: pNPP is a mimic of the phosphorylated tyrosine on ...

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Design of symmetric TIM barrel proteins from first principles

12.08.2015 | Nagarajan, Deepesh; Deka, Geeta; Rao, Megha, BMC Biochemistry, 2015

Background: Computational protein design is a rapidly maturing field within structural biology, with the goal of designing proteins with custom structures and functions. Such proteins could find widespread medical and industrial applications. Here, we have adapted algorithms from the Rosetta ...

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