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1.397 Aktuelle Fachpublikationen in ChemBioChem


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Synthesis and Characterization of photoactivatable doxycycline analogues bearing two‐photon sensitive photoremovable groups suitable for light induced gene expression

17.01.2018 | Alexandre Specht, Bastien Goegan, Firat terzi, Frédéric Bolze, Sidney Cambridge, ChemBioChem, 2018

We report herein the synthesis and the photolytic properties of EANBP and PEG7‐DEACM caged 9‐aminodoxycycline. 9‐Aminodoxycycline is a tetracycline analogue able to activate transcription via the inducible TetOn transgene expression system and can be regioselectively coupled by carbamoylation to ...


Control of protein activity and gene expression by cyclofen‐OH uncaging

17.01.2018 | Weiting Zhang, Fatima Hamouri, Zhiping Feng, Isabelle Aujard, Bertrand Ducos, Shixin Ye, Shimon Weiss, Michel Volovi ..., ChemBioChem, 2018

The use of light to control the expression of genes and the activity of proteins is a rapidly expanding field. While many of these approaches use a fusion between a light activable protein and the protein of interest to control the activity of the later, it is also possible to control the ...


The Fourth Wave of Biocatalysis Emerges—The 13 th International Symposium on Biocatalysis and Biotransformations

16.01.2018 | László Poppe, Beáta G. Vértessy, ChemBioChem, 2018

Ride the wave! Biocatalysis uses nature's catalysts, enzymes and whole cell systems, for synthetic purposes. In a biotransformation, the biocatalyst transforms a well‐defined substrate to the desired product, in contrast to the fermentation process, which produces the desired product from a ...


Efficient catalytic oxidation of 5‐hydroxymethylfurfural to 2,5‐furandicarboxylic acid by magnetic laccase catalyst

15.01.2018 | Ke-Feng Wang, Chun-lei Liu, Kun-yan Sui, Chen Guo, Chun-Zhao Liu, ChemBioChem, 2018

2,5‐Furandicarboxylic acid (FDCA) is a biobased platform chemical for the production of polyesters. The magnetic laccase catalyst with TEMPO as the mediator has the remarkable capability of oxidizing HMF to 2,5‐furandicarboxylic acid (FDCA). Under optimal reaction conditions, a quantitative ...


Investigating the accessibility of nucleosome by duocarmycin B2, Fe(II) peplomycin and MNase using capillary electrophoresis

15.01.2018 | Tingting Zou, Seiichiro Kizaki, Hiroshi Sugiyama, ChemBioChem, 2018

Capillary electrophoresis coupled with DNA 5 Texas Red labeling was used to investigate the ability of duocarmycin B2, Fe(II) peplomycin, and MNase to access the nucleosome. Distinct accessibility patterns of these species to the nucleosome were observed. Duocarmycin B2 was able to enter and ...


Epitope‐Resolved Detection of Peanut‐Specific IgE Antibodies by Surface Plasmon Resonance Imaging

15.01.2018 | Min Shen, Amit A. Joshi, Raghu Vannam, Chandra K. Dixit, Robert G. Hamilton, Challa V. Kumar, James F. Rusling, Mark ..., ChemBioChem, 2018

The front cover picture shows the selective binding of IgE‐coated magnetic beads onto allergen‐functionalized array spots. Binding is detected by surface plasmon resonance imaging (SPRi), as depicted with the reflected red light below the array. Anti‐IgE antibodies and peptide and carbohydrate ...


Biocatalytic Synthesis of Nitriles through Dehydration of Aldoximes: The Substrate Scope of Aldoxime Dehydratases

15.01.2018 | Tobias Betke, Jun Higuchi, Philipp Rommelmann, Keiko Oike, Taiji Nomura, Yasuo Kato, Yasuhisa Asano, Harald Gröger, ChemBioChem, 2018

Nitriles belong to the product classes, which are mostly needed and produced by the chemical industry, playing a major role in various industry segments ranging from high‐volume low‐price sectors such as polymers to low‐volume high‐price sectors such as the chiral pharma drugs. A common ...


Alphanumerical Visual Display Made of DNA Logic Gates for Drug Susceptibility Testing of Pathogens

12.01.2018 | Ryan P. Connelly, Evgeny S. Morozkin, Yulia V. Gerasimova, ChemBioChem, 2018

The cover feature picture shows a seven‐segment display that produces alphanumerical characters in response to a specific nucleic acid fragment. The display is made of DNA‐based logic gates that produce a user‐friendly read‐out of the presence of a pathogen and its drug‐susceptibility ...


Beating Bias in the Directed Evolution of Proteins: Combining High‐Fidelity on‐Chip Solid‐Phase Gene Synthesis with Efficient Gene Assembly for Combinatorial Library Construction

12.01.2018 | Aitao Li, Carlos G. Acevedo‐Rocha, Zhoutong Sun, Tony Cox, Jia Lucy Xu, Manfred T. Reetz, ChemBioChem, 2018

The front cover picture shows symbolically a high‐throughput silicon‐chip‐based DNA solid‐phase synthetic platform (background) for preparing a library of DNA mutants that encode epoxide hydrolase (center) variants. Massive sequencing revealed that 97 % of the theoretically possible DNA mutants ...


Ketonization of proline residues in the peptide chains of actinomycins by a 4‐Oxoproline synthase

12.01.2018 | Siamak Semsary, Ivana Crnovčić, Ronja Driller, Joachim Vater, Bernhard Loll, Ullrich Keller, ChemBioChem, 2018

X‐type actinomycins (Acms) contain 4‐hydroxyproline (Acm X0) or 4‐oxoproline (Acm X2) in their ß‐pentapeptide lactone rings whereas their α‐ring contains proline. We demonstrate that these Acms are formed through asymmetric condensation of Acm half molecules (Acm halves) containing proline with ...


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