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360 Aktuelle Fachpublikationen in Combinatorial Chemistry

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Cystic Fibrosis Mutation Detection with SPR Biosensor in Real Samples via Multiple Surfaces Binding Method

18.05.2017 | Ugur Kayran, Yasin; Ozkan-Ariksoysal, Dilsat; Nur Topkaya, Seda; Tezcanli Kaymaz, Burcin; Kosova Can, Buket, Combinatorial Chemistry, 2017

Abstract: Aim and Objective: Surface Plasmon Resonance (SPR) based biosensor system was developed for the detection of Delta F508 (ΔF508del) Cystic Fibrosis (CF) mutation in both synthetic and real samples. Material and Method: In order to provide an effective hybridization between probe and ...

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Ligand Based-Pharmacophore Modeling and Extended Bi oactivity Prediction for Salinosporamide A, B and C from Marine Actino mycetes Salinispora tropica

18.05.2017 | Dineshkumar, Kesavan; Vasudevan, Aparna; Hopper, Waheeta, Combinatorial Chemistry, 2017

Abstract: Aim and Objective: Actinomycetes produce structurally unique secondary metabolites with pharmaceutically essential bioactivities. Salinispora, an obligate marine actinomycete, produces structurally varied and unique secondary metabolites. There is plenty of scope for development ...

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Magnetite Nanoparticles-Supported APTES as a Powerful and Recoverable Nanocatalyst for the Preparation of 2-Amino-5,10-dihydro- 5,10-dioxo-4H-benzo[g]chromenes and Tetrahydrobenzo[g]quinoline-5,10- diones

18.05.2017 | Ali Ghasemzadeh, Mohammad; Elyasi, Zahra; Azimi-Nasrabad, Mina; Mirhosseini-Eshkevari, Boshra, Combinatorial Chemistry, 2017

Abstract: Aim and Objective: This study introduces a green and effective approach for the preparation of biologically-active heterocyclic compounds including 2-amino-5,10-dihydro-5,10-dioxo-4Hbenzo[ g]chromenes and tetrahydrobenzo[g]quinoline-5,10-diones using one-pot multi-component ...

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Probing into the Molecular Requirements for Antioxidant Activity in Plant Phenolic Compounds Utilizing a Combined Strategy of PCA and ANN

18.05.2017 | Agatonovic-Kustrin, Snezana; W. Morton, David; Ristivojevic, Petar, Combinatorial Chemistry, 2017

Abstract: Aim and Objective: This study investigates molecular structural requirements that are responsible for the antioxidant activity in phenolic compounds. Method: Antioxidant activity of compounds was determined with a 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay. ...

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Molecular Modeling and Dynamics Simulation Analysis of KATNAL1 for Identification of Novel Inhibitor of Sperm Maturation

18.05.2017 | Sarma, Kishore; Roychoudhury, Shubhadeep; Sankar Bora, Sudipta; Dehury, Budheswar; Parida, Pratap; Das, Saurav; Das, ..., Combinatorial Chemistry, 2017

Abstract: Background: Hormone based birth control often causes various side effects. A recent study revealed that temporary infertility without changing hormone levels can be attained by inhibiting Katanin p60 ATPase-containing subunit A-like 1 protein (KATNAL1) which is critical for sperm ...

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Efficient One-Pot Synthesis of Thiazol-2-imine Derivatives through Regioselective Reaction Between Primary Amines, Phenylisothiocyanate, and α-Chloroacetaldehyde

18.05.2017 | Nasiri, Farough; Sabahi-Agabager, Leila, Combinatorial Chemistry, 2017

Abstract: Aim and Objective: Thiazol-2-imine derivatives are interested for their pharmaceutical and biologic activities. A literature survey reveals that there have been no any reports on the synthesis of thiazol-2-imine derivatives without substituents in position C-4 and C-5 via one-pot ...

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Synthesis of Spiro Indole-2-Ones Using Three Component Reaction of N-Alkylisatins and Triphenylphosphonium Intermediates

18.05.2017 | Varasteh Moradi, Ali, Combinatorial Chemistry, 2017

Abstract: Objective: A simple and efficient procedure is achieved for the synthesis of indole-2-one derivatives via three-component reaction of N-alkylisatin, activated acetylenic compounds and alkyl bromide in the presence of triphenylphosphine in water under two conditions; room ...

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Development of a Web-Enabled SVR-Based Machine Learning Platform and its Application on Modeling Transgene Expression Activity of Aminoglycoside-Derived Polycations

18.05.2017 | Zhen, Zhuo; Potta, Thrimoorthy; A. Lanzillo, Nicholas; Rege, Kaushal; M. Breneman, Curt, Combinatorial Chemistry, 2017

Abstract: Objective: Support Vector Regression (SVR) has become increasingly popular in cheminformatics modeling. As a result, SVR-based machine learning algorithms, including Fuzzy-SVR and Least Square-SVR (LS-SVR) have been developed and applied in various research areas. However, at ...

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Identification of Novel Antagonists for Rab38 Protein by Homology Modeling and Virtual Screening

17.01.2017 | Haredi Abdelmonsef, Aboubakr; Dulapalli, Ramasree; Dasari, Thirupathi; Souda Padmarao, Lavanya; Mukkera, Thirupathi; ..., Combinatorial Chemistry, 2017

Abstract: Background: The Rab family proteins are involved in membrane trafficking, cell growth and differentiation. Rab38 is implicated in the biogenesis of melanosomes that help in the synthesis, storage and transport of melanin pigments. The Rab38 protein is overexpressed at the RNA level in ...

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Molecular Modeling and Virtual Screening Approach to Discover Potential Antileishmanial Inhibitors Against Ornithine Decarboxylase

17.01.2017 | Kumar Pandey, Rajan; Prajapati, Priyanka; Goyal, Sukriti; Grover, Abhinav; Kumar Prajapati, Vijay, Combinatorial Chemistry, 2017

Abstract: Background: Visceral leishmaniasis (VL) is a tropical neglected disease, which encounters poorest of poor people living in Asia, Africa and Latin America; causing the mortality of more than 30,000 people worldwide. The armamentarium for the treatment of VL cases is limited and ...

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