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888 Aktuelle Fachpublikationen in CSH Perspectives

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[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Pasteur Tetravalent Dengue Vaccine

01.06.2018 | Bruno Guy, CSH Perspectives, 2018

Dengue is a still-growing public health concern in many tropical and subtropical regions of the world. The development and implementation of an effective dengue vaccine in these regions is a high priority. This insight focuses on the expected characteristics of a safe and efficacious vaccine, ...

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[Molecular Biology] Circadian Posttranscriptional Regulatory Mechanisms in Mammals

01.06.2018 | Carla B. Green, CSH Perspectives, 2018

The circadian clock drives rhythms in the levels of thousands of proteins in the mammalian cell, arising in part from rhythmic transcriptional regulation of the genes that encode them. However, recent evidence has shown that posttranscriptional processes also play a major role in generating the ...

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[Cell Biology] Microtubules and Microtubule-Associated Proteins

01.06.2018 | Holly V. Goodson; Erin M. Jonasson, CSH Perspectives, 2018

Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are ...

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[Cell Signaling] TGF-{beta} Family Signaling in Early Vertebrate Development

01.06.2018 | Joseph Zinski; Benjamin Tajer; Mary C. Mullins, CSH Perspectives, 2018

TGF-β family ligands function in inducing and patterning many tissues of the early vertebrate embryonic body plan. Nodal signaling is essential for the specification of mesendodermal tissues and the concurrent cellular movements of gastrulation. Bone morphogenetic protein (BMP) signaling patterns ...

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[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials

01.06.2018 | Aravinda M. de Silva; Eva Harris, CSH Perspectives, 2018

Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of ...

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[Molecular Biology] Cytokines and Long Noncoding RNAs

01.06.2018 | Susan Carpenter; Katherine A. Fitzgerald, CSH Perspectives, 2018

Cytokines and long noncoding RNAs (lncRNAs) are intertwined in the regulatory circuit controlling immunity. lncRNA expression levels are altered following cytokine stimulation in a cell-type-specific fashion. lncRNAs, in turn, regulate the inducible expression of cytokines following immune ...

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[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: There Is Only One True Winner

01.06.2018 | Scott B. Halstead, CSH Perspectives, 2018

The scientific community now possesses information obtained directly from human beings that makes it possible to understand why breakthrough-enhanced dengue virus (DENV) infections occurred in children receiving Sanofi Pasteur’s Dengvaxia tetravalent live attenuated vaccine and to predict the ...

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[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: The Challenges of a Dengue Vaccine

01.06.2018 | Gavin Screaton; Juthathip Mongkolsapaya, CSH Perspectives, 2018

A dengue vaccine has been pursued for more than 50 years and, unlike other flaviviral vaccines such as that against yellow fever, progress has been slow. In this review, we describe progress toward the first licensed dengue vaccine Dengvaxia, which does not give complete protection against ...

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[Immunology] Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination?: The Risks of Incomplete Immunity to Dengue Virus Revealed by Vaccination

01.06.2018 | Stephen S. Whitehead; Kanta Subbarao, CSH Perspectives, 2018

Immune enhancement of dengue disease continues to be a concern for those with incomplete immunity in endemic areas. Advanced testing and follow-up of a newly available live attenuated dengue vaccine has recently shown the ability of vaccination to predispose some recipients for a severe outcome ...

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[Cell Signaling] Cell-Cell Contact and Receptor Tyrosine Kinase Signaling

01.06.2018 | Christine Chiasson-MacKenzie; Andrea I. McClatchey, CSH Perspectives, 2018

The behavior of cells within tissues is governed by the activities of adhesion receptors that provide spatial cues and transmit forces through intercellular junctions, and by growth-factor receptors, particularly receptor tyrosine kinases (RTKs), that respond to biochemical signals from the ...

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