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848 Aktuelle Fachpublikationen in Current Topics in Medicinal Chemistry

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Antimalarials: Molecular Drug Targets and Mechanism of Action

28.06.2017 | O. Achieng, Angela; Rawat, Manmeet; Ogutu, Bernhards; Guyah, Bernard; Michael Ong'echa, John; J. Perkins, Douglas; K ..., Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Despite a reduction in the global burden of malaria, the disease remains responsible for 214 million cases and 438,000 deaths annually with 88% of the mortality occurring in sub-Saharan Africa. Malaria control largely depends on effective chemotherapy. However, the ...

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InsP3 Signaling in Apicomplexan Parasites

28.06.2017 | R.S. Garcia, Celia; Alves, Eduardo; H. S. Pereira, Pedro; J. Bartlett, Paula; P. Thomas, Andrew; Mikoshiba, Katsuhik ..., Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Phosphoinositides (PIs) and their derivatives are essential cellular components that form the building blocks for cell membranes and regulate numerous cell functions. Specifically, the ability to generate myo-inositol 1,4,5-trisphosphate (InsP3) via phospholipase C ...

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Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication

28.06.2017 | Kadian, Kavita; Gupta, Yash; Kempaiah, Prakasha; Gupta, Nikesh; Sharma, Arun; Rawat, Manmeet, Current Topics in Medicinal Chemistry, 2017

Abstract: Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic ...

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An Overview of Currently Available Antimalarials

28.06.2017 | Yu. Gorobets, Nikolay; V. Sedash, Yuriy; K. Singh, Brajendra; Poonam; Rathi, Brijesh, Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Despite the substantial progress over the time, malaria remains a major public health concern and causing hundreds of thousands of deaths. Resistance to the available antimalarial therapy increases threat to the global public health. Objective: Overview of ...

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Challenges with Mosquito-borne Viral Diseases: Outbreak of the Monsters

28.06.2017 | Gautam, Renu; Mishra, Sweta; Milhotra, Archana; Nagpal, Ritika; Mohan, Mradul; Singhal, Anchal; Kumari, Pratibha, Current Topics in Medicinal Chemistry, 2017

Abstract: Background: The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and ...

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Proteases in Mosquito Borne Diseases: New Avenues in Drug Development

28.06.2017 | Pant, A.; Pasupureddy, R.; Pande, V.; Seshadri, S.; Dixit, R.; C. Pandey, K., Current Topics in Medicinal Chemistry, 2017

Abstract: Introduction: Mosquito borne diseases continue to propagate and cause millions of deaths annually. They are caused either by protozoan parasites such as Plasmodium, Toxoplasma or by flaviviruses including Dengue and Zika. Among the proteome of such parasitic organisms, proteases ...

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Mycobacterial DNA Replication as a Target for Antituberculosis Drug Discovery

28.06.2017 | PŦ#130;ocinska, Renata; Korycka-Machala, Malgorzata; Plocinski, Przemyslaw; Dziadek, Jaroslaw, Current Topics in Medicinal Chemistry, 2017

Abstract: Background: Mycobacterium tuberculosis (M. tuberculosis), the causative agent of tuberculosis, is a leading infectious disease organism, causing millions of deaths each year. This serious pathogen has been greatly spread worldwide and recent years have observed an increase in the ...

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Synthesis, Properties, and Mechanism of Action of New Generation of Polycyclic Glycopeptide Antibiotics

28.06.2017 | N. Olsufyeva, Eugenia; N. Tevyashova, Anna, Current Topics in Medicinal Chemistry, 2017

Abstract: Introduction: The increased resistance of glycopeptide based antibiotics has become a serious problem for the chemotherapy of infections triggered by resistant Gram-positive bacteria. This has motivated the urgent sincere efforts to develop potent glycopeptide-based antibiotics in ...

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Fungal Biofilm – A Real Obstacle Against an Efficient Therapy: Lessons from Candida

06.06.2017 | Pereira de Mello, Thais; de Souza Ramos, Lívia; Adriana Braga-Silva, Lys; Helena Branquinha, Marta; Luis Souza dos S ..., Current Topics in Medicinal Chemistry, 2017

Abstract: The past decades have witnessed a dramatic increase in invasive fungal infections, especially caused by different species belonging to the Candida genus. Nowadays, even after many improvements in several medical procedures, Candida infections (candidiasis) still account for an ...

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Riboswitches as Potential Targets for the Development of Anti-Biofilm Drugs

06.06.2017 | A. Reyes-Darias, Jose; Krell, Tino, Current Topics in Medicinal Chemistry, 2017

Abstract: In nature, bacteria can exist as single motile cells or as sessile cellular community, known as microbial biofilms. Bacteria within biofilms are embedded in a self-produced extracellular matrix that makes them more resistant to antibiotic treatment and responses of the host immune ...

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