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2.533 Aktuelle Fachpublikationen in FEBS Journal


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Functions of autophagy in the tumor microenvironment and cancer metastasis

21.01.2018 | Erin E. Mowers, Marina N Sharifi, Kay F. MacLeod, FEBS Journal, 2018

Abstract Macro‐autophagy is an ancient and highly‐conserved self‐degradative process that plays a homeostatic role in normal cells by eliminating organelles, pathogens and protein aggregates. Autophagy, as it is routinely referred to, also allows cells to maintain metabolic sufficiency and ...


Post‐translational incorporation of 3,4‐dihydroxyphenylalanine into the C‐terminus of α‐tubulin in living cells

17.01.2018 | Yanela M. Dentesano, Yanina Ditamo, Cristian Hansen, Carlos A. Arce, C.Gastón Bisig, FEBS Journal, 2018

Abstract The C‐terminal tyrosine (Tyr) of the α‐tubulin chain is subjected to post‐translational removal and re‐addition in a process termed the “detyrosination/tyrosination cycle”. We showed in previous studies using soluble rat brain extracts that L‐3,4‐dihydroxyphenylalanine (L‐Dopa) is ...


Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae

17.01.2018 | Araceli Vázquez‐Ibarra, Laia Subirana, Laura Ongay‐Larios, Laura Kawasaki, Eréndira Rojas‐Ortega, Miriam Rodríguez‐G ..., FEBS Journal, 2018

Abstract Yeast cells respond to hyperosmotic stress by activating the HOG pathway, which consists of two branches, Hkr1/Msb2‐Sho1 and Sln1, which trigger phosphorylation and nuclear internalisation of the Hog1 MAPK. In the nucleus, Hog1 regulates gene transcription and cell cycle progression, ...


Canonical signaling and nuclear activity of mTOR: a teamwork effort to regulate metabolism and cell growth

16.01.2018 | Vincent Giguère, FEBS Journal, 2018

Abstract Mechanistic (or mammalian) target of rapamycin (mTOR) is a kinase that regulates almost all functions related to cell growth and metabolism in response to extra‐ and intracellular stimuli such as availability of nutrients, presence of growth factors or the energy status of the cell. ...


Inhibition of UVSSA ubiquitination suppresses transcription‐coupled nucleotide excision repair deficiency caused by dissociation from USP7

11.01.2018 | Mitsuru Higa, Kiyoji Tanaka, Masafumi Saijo, FEBS Journal, 2018

Abstract Transcription‐coupled nucleotide excision repair (TC‐NER) is a subpathway of nucleotide excision repair that efficiently removes transcription‐blocking DNA damage from the transcribed strands of active genes. UVSSA is a causative gene for UV‐sensitive syndrome (UVSS), which is an ...


The retinamide VNLG‐152 inhibits AR/AR‐V7 and MNK‐eIF4Esignaling pathways to suppress EMT and castration‐resistant prostate cancer xenograft growth

11.01.2018 | Vidya P. Ramamurthy, Senthilmurugan Ramalingam, Lalji K. Gediya, Vincent C.O. Njar, FEBS Journal, 2018

Abstract VNLG‐152, a lead novel retinamide (NR) shown to suppress growth and progression in genetically diverse PCa cells via inhibition of AR signaling and eIF4E translational machinery. Herein, we report therapeutic effects of VNLG‐152 on castration resistant prostate cancer (CRPC) growth ...


Crystal structure of the DNA–binding domain of the LysR–type transcriptional regulator CbnR in complex with a DNA fragment of the recognition binding site in the promoter region

11.01.2018 | Maharani Pertiwi Koentjoro, Naruhiko Adachi, Miki Senda, Naoto Ogawa, Toshiya Senda, FEBS Journal, 2018

Abstract LysR‐type transcriptional regulators (LTTRs) are among the most abundant transcriptional regulators in bacteria. CbnR is an LTTR derived from Cupriavidus necator (formerly Alcaligenes eutrophus or Ralstonia eutropha) NH9 and is involved in transcriptional activation of the cbnABCD ...


Pulmonary endoplasmic reticulum stress: Scars, Smoke and Suffocation

11.01.2018 | Jennifer A. Dickens, Elke Malzer, Joseph E. Chambers, Stefan J. Marciniak, FEBS Journal, 2018

Abstract Protein misfolding within the endoplasmic reticulum (ER stress) can be a cause or consequence of pulmonary disease. Mutation of proteins restricted to the alveolar type II pneumocyte can lead to inherited forms of pulmonary fibrosis, but even sporadic cases of pulmonary fibrosis ...


The role of Nrf2 signaling in counteracting neurodegenerative diseases

11.01.2018 | Albena T. Dinkova‐Kostova, Rumen V. Kostov, Aleksey G. Kazantsev, FEBS Journal, 2018

Abstract The transcription factor Nrf2 (nuclear factor erythroid 2 p45‐related factor 2) functions at the interface of cellular redox and intermediary metabolism. Nrf2 target genes encode antioxidant enzymes, and proteins involved in xenobiotic detoxification, repair and removal of damaged ...


The FEBS Journal in 2018 – putting a bit of color in your life, and your figures

08.01.2018 | Seamus J. Martin, FEBS Journal, 2018

Seamus Martin holds the Smurfit Chair of Medical Genetics at the Smurfit Institute of Genetics, Trinity College Dublin, Ireland. He works on all aspects of cell death control and is especially interested in the links between cell death, cell stress and inflammation. He received the ...


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