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PKA‐binding domain of AKAP8 is essential for direct interaction with DPY30 protein

30.12.2017 | Anna Bieluszewska, Martyna Weglewska, Tomasz Bieluszewski, Krzysztof Lesniewicz, Elzbieta Poreba, FEBS Journal, 2017

Abstract The main function of the A kinase‐anchoring proteins (AKAPs) is to target the cAMP‐dependent protein kinase A (PKA) to its cellular substrates through the interaction with its regulatory subunits. Besides anchoring of PKA, AKAP8 participates in regulating the H3K4 histone ...


Identification of a novel nucleophosmin‐interaction motif in the tumor suppressor p14arf

28.12.2017 | Enrico Luchinat, Sara Chiarella, Mimma Franceschini, Adele Di Matteo, Maurizio Brunori, Lucia Banci, Luca Federici, FEBS Journal, 2017

Abstract The tumor suppressor p14arf interacts, in response to oncogenic signals, with the p53 E3‐ubiquitin ligase HDM2, thereby resulting in p53 stabilization and activation. In addition, it also exerts tumor suppressive functions in p53‐independent contexts. The activities of p14arf are ...


Structural Plasticity of Mini‐M Conotoxins: Expression of all mini‐M subtypes by Conus regius

28.12.2017 | Aldo Franco, Sanaz Dovell, Carolina Moller, Meghan Grandal, Evan Clark, Frank Marí, FEBS Journal, 2017

Abstract The mini‐M conotoxins are peptidic scaffolds found in the venom of cones snails. These scaffolds are tightly folded structures held together by three disulfide bonds with a CC‐C‐C‐CC arrangement (conotoxin framework III) and belong to the M Superfamily of conotoxins. Here we describe ...


Membrane Localization of a Myb3 Transcription Factor Regulated by a TvCyP1 Cyclophilin in the Parasitic Protozoan Trichomonas vaginalis

28.12.2017 | Chien‐Hsin Chu, Yu‐Hsin Huang, Hsing‐Wei Liu, Hong‐Ming Hsu, Jung‐Hsiang Tai, FEBS Journal, 2017

Abstract In Trichomonas vaginalis, a TvCyP1 cyclophilin was previously demonstrated to regulate the nuclear translocation of Myb1 and Myb3, which respectively repress and activate transcription of an adhesion protein ap65‐1 gene. In the present study, TvCyP1 was found to bind to Myb3 at sites ...


A stereospecific carboxyl esterase from Bacillus coagulans hosting non‐lipase activity within a lipase‐like fold

26.12.2017 | Valerio De Vitis, Cristina Nakhnoukh, Andrea Pinto, Martina Letizia Contente, Alberto Barbiroli, Mario Milani, Marti ..., FEBS Journal, 2017

Abstract Microbial carboxylesterases are important biocatalysts that selectively hydrolyze an extensive range of esters. Here, we report the biochemical and structural characterization of an atypical carboxylesterase from Bacillus coagulans (BCE), endowed with high enantioselectivity towards ...


Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms

19.12.2017 | Allison R. O'Rourke, Angus Lindsay, Michael D. Tarpey, Samantha Yuen, Preston McCourt, D'anna M. Nelson, Benjamin J. ..., FEBS Journal, 2017

Abstract While αsk‐actin isoforms predominate in adult striated muscle, skeletal muscle‐specific knockouts of non‐muscle cytoplasmic βcyto‐ or γcyto‐actin each cause a mild, but progressive myopathy affected by an unknown mechanism. Using transmission electron microscopy, we identified ...


Inositol 1,4,5‐trisphosphate receptors and neurodegenerative disorders

18.12.2017 | Polina A. Egorova, Ilya B. Bezprozvanny, FEBS Journal, 2017

Abstract Inositol 1,4,5‐trisphosphate receptor (IP3R) is an intracellular ion channel that mediates the release of calcium ions from the endoplasmic reticulum (ER). IP3R plays a role in basic biological functions, such as cell division, differentiation, fertilization, and cell death; and is ...


Announcing the winners of our 50th Anniversary Science Communication Competition

18.12.2017 | Emily J. Chenette, FEBS Journal, 2017

The FEBS Journal is pleased to announce the three winners of its 50th Anniversary Science Communication Competition. Read on to see their prize‐winning entries!


Macrophage p38 kinase inhibition for liver regeneration

18.12.2017 | Klaus Schulze‐Osthoff, Heike Bantel, FEBS Journal, 2017

In this issue, Ying etal. show that p38α kinase (MAPK14) controls macrophage polarization following acute liver injury. Myeloid cell‐specific depletion of p38α promotes polarization to anti‐inflammatory M2 macrophages and prevents pro‐inflammatory cytokine secretion that ameliorate acute liver ...


Issue Information

18.12.2017 | FEBS Journal, 2017

This issue celebrates the 50th anniversary of The FEBS Journal. Cover illustration by Matthew McClements, Blink Studio Ltd,


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