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4.008 Aktuelle Fachpublikationen in Lab on a Chip

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A high-throughput multi-microfluidic crystal generator (MMicroCryGen) platform for facile screening of polymorphism and crystals morphology for pharmaceutical compounds

20.06.2018 | Elena Simone; James McVeigh; Nuno M Reis; Zoltan Nagy, Lab on a Chip, 2018

In this work a novel multi-microfluidic crystallization platform called MMicroCryGen is presented, enabling the generation of single crystals and fast and easy screening for polymorphism and crystal habit of solid compounds without any complex fluid handling. The MMicroCryGen device allows ...

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Anti-thrombotic strategies for microfluidic blood processing

20.06.2018 | Keith Wong; Jon Edd; Shannon Tessier; Will D. Moyo; Baris Mutlu; Lauren D. Bookstaver; Kathleen L. Miller; Stefan He ..., Lab on a Chip, 2018

The redundant mechanisms involved in blood coagulation are crucial for rapid hemostasis. Yet they also create challenges in blood processing in medical devices and lab-on-a-chip systems. In this work, we investigate the effects of both shear stress and hypothermic blood storage on thrombus ...

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User-defined local stimulation of live tissue through a movable microfluidic port

20.06.2018 | Megan A. Catterton; Austin F. Dunn; Rebecca R. Pompano, Lab on a Chip, 2018

Many in vivo tissue responses begin locally, yet most in vitro stimuli are delivered globally. Microfluidics has a unique ability to provide focal stimulation to tissue samples with precise control over fluid location, flow rate, and composition. However, previous devices utilizing fixed ports ...

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Static droplet array for culturing single live adherent cells in an isolated chemical microenvironment

20.06.2018 | Amin Hassanzadeh-Barforoushi; Andrew Law; Abbas Hejri; Mohsen Asadnia; David Gallego-Ortega; Christopher Ormandy; ..., Lab on a Chip, 2018

We present here a new method to easily and reliably generate an array of hundreds of dispersed nanoliter-volume semi-droplets for single-cells culture and analysis. The liquid segmentation step occurs directly in indexed traps by a tweezer-like mechanism and is stabilized by spatial confinement. ...

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Dynamic CTC Phenotypes in Prostate Cancer Metastatic Models Visualized Using Magnetic Ranking Cytometry

20.06.2018 | Leyla Kermanshah; Mahla Poudineh; Sharif Ahmed; Luan Matthew Nguyen; Sanjana Srikant; Rhema Makonnen; Fernando Pena ..., Lab on a Chip, 2018

Tumors can shed thousands of cells into the circulation daily. These circulating tumor cells (CTCs) are heterogeneous, and their phenotypes change dynamically. Real-time monitoring of CTC phenotypes is crucial to elucidate the role of CTCs in the metastatic cascade. Here, we monitor phenotypic ...

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A rapid and eco-friendly isothermal amplification microdevice for multiplex detection of foodborne pathogens

20.06.2018 | Thi Ngoc Diep Trinh; Nae Yoon Lee, Lab on a Chip, 2018

In this study, a plastic microdevice based on loop-mediated isothermal amplification (LAMP) was fabricated for the amplification and on-chip fluorescence detection of multiple pathogens. Papers infused with LAMP reagents and specific primers were embedded inside multiple reaction chambers of the ...

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Microfluidics-enabled rational design of immunomagnetic nanomaterial and its shape effect in liquid biopsy

20.06.2018 | Nanjing Hao; Yuan Nie; Ting Shen; John X. J. Zhang, Lab on a Chip, 2018

Microfluidics brings unique opportunities for nanomaterials synthesis toward efficient liquid biopsy. Herein, we developed microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle ...

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NemaFlex: A microfluidics-based technology for standardized measurement of muscular strength of C. elegans

12.06.2018 | Mizanur Rahman; Jennifer Hewitt; Frank Van-Bussel; Hunter Edwards; Jerzy Blawzdziewicz; Nathaniel Szewczyk; Monica D ..., Lab on a Chip, 2018

Muscle strength is a functional measure of quality of life in humans. Declines in muscle strength are manifested in diseases as well as during inactivity, aging, and space travel. With conserved muscle biology, the simple genetic model C. elegans is a high throughput platform in which to identify ...

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A pumpless body-on-a-chip model using a primary culture of human intestinal cells and a 3D culture of liver cells

12.06.2018 | Huanhuan Joyce Chen; Paula Miller; Michael L. Shuler, Lab on a Chip, 2018

We describe an expanded modular gastrointestinal (GI) tract–liver system by co-culture of primary human intestinal epithelial cells (hIECs) and 3D liver mimic. The two organ body-on-chip design consisted of GI and liver tissue compartments that were connected by fluidic medium flow driven via ...

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Additive Manufacturing of Three-dimensional (3D) Microfluidic-based Microelectromechanical Systems (MEMS) for Acoustofluidic Applications

12.06.2018 | Ellen Cesewski; Alexander P. Haring; Yuxin Tong; Manjot Singh; Rajan Thakur; Sahil Laheri; Kaitlin A. Read; Michael ..., Lab on a Chip, 2018

Three-dimensional (3D) printing now enables the fabrication of novel 3D structural electronics and microfluidics. However, conventional subtractive manufacturing processes for MEMS fabrication relatively limit device structure to two dimensions and require post-processing steps for interface with ...

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