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4.008 Aktuelle Fachpublikationen in Lab on a Chip


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Microfluidic nozzle device for ultrafine fiber solution blow spinning with precise diameter control

12.06.2018 | Eddie Hofmann; Kilian Krüger; Christian Haynl; Thomas Scheibel; Martin Trebbin; Stephan Förster, Lab on a Chip, 2018

We present a microfluidic nozzle device for the controlled continuous solution blow spinning of ultrafine fibers. The device is fabricated by soft lithography techniques and is based on the principle of a gas dynamic virtual nozzle for precise three-dimensional gas focusing of the spinning ...


A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function

12.06.2018 | Xiaolin Wang; Da Zhao; Duc T. T. Phan; Jing-Quan Liu; Xiang Chen; Bin Yang; Christopher Hughes; Weijia Zhang; Abraha ..., Lab on a Chip, 2018

Autonomous and self-powered micropumps are in critical demand for versatile cell- and tissue-based applications as well as for low-cost point-of-care testing (POCT) in microfluidics fields. The hydrostatic pressure-driven passive micropumps are simple and widely used, but they cannot maintain ...


Maximizing the impact of microphysiological systems with in vitro–in vivo translation

12.06.2018 | Murat Cirit; Cynthia L. Stokes, Lab on a Chip, 2018

Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here, we first summarize why MPSs are needed in ...


Nitrate measurement in droplet flow: gas-mediated crosstalk and correction

12.06.2018 | Adrian M. Nightingale; Sammer-ul Hassan; Gareth W. H. Evans; Sharon M. Coleman; Xize Niu, Lab on a Chip, 2018

In droplet microfluidics, droplets have traditionally been considered discrete self-contained reaction chambers, however recent work has shown that dissolved solutes can transfer into the oil phase and migrate into neighbouring droplets under certain conditions. The majority of reports on such ...


Sequencing of human genomes extracted from single cancer cells isolated in a valveless microfluidic device

12.06.2018 | Rodolphe Marie; Marie Pødenphant; Kamila Koprowska; Loic Bærlocher; Roland C. M. Vulders; Jennifer Wilding ..., Lab on a Chip, 2018

Sequencing the genomes of individual cells enables the direct determination of genetic heterogeneity amongst cells within a population. We have developed an injection-moulded valveless microfluidic device in which single cells from colorectal cancer derived cell lines (LS174T, LS180 and RKO) and ...


Scalable production of double emulsion drops with thin shells

12.06.2018 | A. Vian; B. Reuse; E. Amstad, Lab on a Chip, 2018

Double emulsions are often used as containers to perform high throughput screening assays and as templates for capsules. These applications require double emulsions to be mechanically stable such that they do not coalesce during processing and storage. A possibility to increase their stability is ...


Pneumatic microfluidic cell compression device for high-throughput study of chondrocyte mechanobiology

12.06.2018 | Donghee Lee; Alek G. Erickson; Taesun You; Andrew T. Dudley; Sangjin Ryu, Lab on a Chip, 2018

Hyaline cartilage is a specialized type of connective tissue that lines many moveable joints (articular cartilage) and contributes to bone growth (growth plate cartilage). Hyaline cartilage is composed of a single cell type, the chondrocyte, which produces a unique hydrated matrix to resist ...


Feedback Control for Defect-free Alignment of Colloidal Particles

12.06.2018 | Yu Gao; Richard Lakerveld, Lab on a Chip, 2018

Precise alignment of small-scale building blocks into specific structural features is important for the manufacture of novel materials. Directed self-assembly is a promising route to align such small-scale building blocks with single-particle resolution. However, reliable alignment via directed ...


A Fully-Integrated Testing Device for PCR-Free Viral Nucleic Acid Detection in Whole Blood

06.06.2018 | Wenhan Liu; Jagotamoy Das; Adam Mepham; Carine Nemr; Edward H Sargent; Shana O Kelley, Lab on a Chip, 2018

Developing integrated devices for automated nucleic acid testing (NAT) is critical for infectious disease diagnosis to be performed outside of centralized laboratories. The gold standard methods for NAT are enzymatic amplification methods like the polymerase chain reaction that typically require ...


Microfluidic chip with movable layers for the manipulation of biochemicals

06.06.2018 | Islam Seder; Dong-Min Kim; Sang-Hyun Hwang; Heungsup Sung; Dong-Eun Kim; Sung-Jin Kim, Lab on a Chip, 2018

A simple and effective platform that can conglomerate various microfluidic functions in a single chip is essential for many bioassays, especially for point-of-care testing applications. Here, a chip that exploits surface tension in solutions with movable top and bottom layers is presented, for ...


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