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598 Aktuelle Fachpublikationen in Letters in Organic Chemistry

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A Novel Azo-Calixaren Derivative Based on 2,6-diamino Pyridine: Synthesis, Characterization and Antibacterial Evaluation

28.06.2017 | Rahnama Lakomehsari, Kaabeh; Taghvaei Ganjali, Saeed; Zadmard, Reza; Roshan, Mina, Letters in Organic Chemistry, 2017

Abstract: Background: Azocalix[4] arene derivative based on 2,6-diamino pyridine has been synthesized from diazo-coupling reaction between tetradiazonium salt of calix[4]arene and 2,6-diaminopyridine, and characterized by various spectroscopic methods such as IR, 1HNMR, 13CNMR and Mass ...

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A Facile and Efficient One-pot Three Component Route to New Bis(1,2,4- Oxadiazole) Linked with Polyoxyethylene Chain

28.06.2017 | Ghrab, Saad; Aroua, Lotfi; Beji, Mohamed, Letters in Organic Chemistry, 2017

Abstract: Background: The synthesis of effective drugs is very important for the scientist. Due to the beneficial pharmacological properties of certain molecules containing the 1,2,4-oxadiazole moiety, the aim of this manuscript is to develop a one pot three component reaction for the ...

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Chiron Approach to Formal Synthesis of 8,9-dideoxyneodysiherbaine (MSVIII-19)

28.06.2017 | Sanchez-Eleuterio, Alma; M. Mastranzo, Virginia; Quintero, Leticia; Sartillo-Piscil, Fernando, Letters in Organic Chemistry, 2017

Abstract: Background: The synthesis of biologically active model compounds represents a valuable tool for medicinal chemistry. In this regard, the synthesis of MSVII-19, a structurally simplified model compound of Dysiherbaine, developed by the group of Sasaki, was synthesized with the ...

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A New MCR Strategy Generating a Collection of Skeletally Diverse Simple Molecules Combinatorially

28.06.2017 | Nandi, Sibaji; Gupta, Ajay; Kumar Pal, Amarta, Letters in Organic Chemistry, 2017

Abstract: Background: 1,4 Dihydropyridines (1,4 DHPs), chromeno[4,3-b] quinolines and pyrimido [4,5-b]quinolines are biologically and pharmaceutically important heterocycles. They are also present in many natural products. Many methods have been applied for their synthesis but each method ...

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Synthesis and Evaluation of Novel Pyrido[1,2-b][1,2,4]triazine-2,6-dione and Pyrido[1,2-b][1,2,4]triazepine-2,7-dione Derivatives as Antioxidant Agents

28.06.2017 | Serrar, Houda; Marmouzi, Iliais; Benzekri, Zakaria; Boukhris, Said; Hassikou, Amina; Faouzi, My El Abbes; Souizi, Ab ..., Letters in Organic Chemistry, 2017

Abstract: Background: During the last years, condensed pyridine compounds have received much attention because of their immense biological properties. In this article, a practical and efficient synthesis of their novel series pyrido[1,2-b][1,2,4]triazine-2,6-dione and ...

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A Rapid, Solvent-Free Deprotection of Methoxymethyl (MOM) Ethers by pTSA; An Eco-Friendly Approach

28.06.2017 | Pandurangan, Nanjan, Letters in Organic Chemistry, 2017

Abstract: Background: Ease of preparation and alkaline stability of methoxymethyl (MOM) makes it an important hydroxyl protecting group. A number of methods are available for the deprotection of MOM. Though the methods are good in general, they use solvents, require prolonged reaction time ...

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A Simple, Mild and Efficient Oxidation of Benzylic Alcohols in the Presence of NBS/KOAc in Aqueous Solution

28.06.2017 | Wu, Jianglong; Liu, Yan; Liu, Ping; Gu, Chengzhi, Letters in Organic Chemistry, 2017

Abstract: Background: The oxidation of benzylic alcohols to carbonyl compounds is a fundamental reaction in organic synthesis. In traditional oxidation processes, a large amount of toxic and volatile organic solvents and metal oxidants are used. Thus, developing environmentally benign ...

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Constituents from Ircinia echinata and their Antiproliferative Effect on Six Human Cancer Cell Strains

28.06.2017 | Van Kiem, Phan; Thi Dung, Duong; Thi Trang, Do; Hong Quang, Tran; Thi Thanh Ngan, Nguyen; Minh Ha, Tran; Le Tuan Anh ..., Letters in Organic Chemistry, 2017

Abstract: Background: Marine sponges have produced a large number of secondary metabolites and become a potent source of anti-cancer agents for drugs discovery. Screening results indicated that methanol extract of the sponge Ircinia echinata significantly induced in vitro antiproliferative ...

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Fungal Biotechnology of the Red Sea Alga Sarggassum subrepandum with Potential of Anticancer and Anti-Hepatitis C Virus Protease Activities

28.06.2017 | W. Hawas, Usama; Al-Farawati, Radwan; T. Abou El-Kassem, Lamia; F. Ahmed, Eman, Letters in Organic Chemistry, 2017

Abstract: Background: Marine algal-derived endophytic fungi have attracted considerable attention in the recent decade due to their prolific production of structurally diverse secondary metabolites with various biological activities. In this study, the potential inhibition of endophytic ...

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The Chemistry of α,β-Ditosyloxy Ketones: Hypervalent Iodine (III) Mediated Synthesis of Alkynes from α,β-Unsaturated Carbonyl Compounds Containing Pyrazole Moiety

28.06.2017 | Ranjan, Pooja; Arora, Loveena; Prakash, Richa; K. Aneja, Deepak; Prakash, Om, Letters in Organic Chemistry, 2017

Abstract: Background: The present study is an effort to extend the utility of the α,β-ditosyloxy chalcone derivatives in establishing the reaction patterns of these compounds which at once was thought that they might behave similar to α,β-dibromo ketones but the results obtained were quite ...

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